Structure formation dynamics in drawing silica photonic crystal fibres

© 2018, Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature. The special features of photonic crystal fibres (PCFs) are achieved by their air hole structures. PCF structure is determined and formed by its origin preform design and drawing process. Therefore, structure formation dynamics in drawing PCF is important for the fabrication of PCF achieving desirable structure and thus the intended feature. This paper will investigate structure formation dynamics of PCF drawing in relation to key parameters and conditions, such as hole dimension, temperature, pressure, etc

A systems genetics resource and analysis of sleep regulation in the mouse

<div><p>Sleep is essential for optimal brain functioning and health, but the biological substrates through which sleep delivers these beneficial effects remain largely unknown. We used a systems genetics approach in the BXD genetic reference population (GRP) of mice and assembled a comprehensive experimental knowledge base comprising a deep “sleep-wake” phenome, central and peripheral transcriptomes, and plasma metabolome data, collected under undisturbed baseline conditions and after sleep deprivation (SD). We present analytical tools to interactively interrogate the database, visualize the molecular networks altered by sleep loss, and prioritize candidate genes. We found that a one-time, short disruption of sleep already extensively reshaped the systems genetics landscape by altering 60%–78% of the transcriptomes and the metabolome, with numerous genetic loci affecting the magnitude and direction of change. Systems genetics integrative analyses drawing on all levels of organization imply α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and fatty acid turnover as substrates of the negative effects of insufficient sleep. Our analyses demonstrate that genetic heterogeneity and the effects of insufficient sleep itself on the transcriptome and metabolome are far more widespread than previously reported.</p></div