Concurrence of Stevens-Johnson Syndrome and Bilateral Parotitis after Minocycline Therapy

Minocycline is an antibiotic of tetracycline derivatives that is commonly used in the treatment of moderate to severe acne vulgaris. It has been reported to cause rare adverse events from mild cutaneous eruption to severe forms including drug-induced lupus, serum sickness-like reaction, and hypersensitivity reactions, etc. The risks of adverse events attributed to minocycline have not been ascertained reliably and there are concerns about the safety of minocycline which could possibly result in life-threatening events such as the Stevens-Johnson syndrome. Here we demonstrate an unusual case of Stevens-Johnson syndrome in conjunction with bilateral parotitis after the intake of minocycline in a Korean boy suggesting discreet use of the drug

Pressure and thermal effects on superhydrophobic friction reduction in a microchannel flow

textAs the fluidic devices are miniaturized to improve portability, the friction of the microchannel becomes intrinsically high and a high pumping power will be required to drive the fluid. Since the pumping power delivered by portable devices is limited, one method to reduce this is to render the surface to become slippery. This can be achieved by roughening up the microchannel wall and form a bed of air pockets between the roughness elements, which is known as the superhydrophobic Cassie-Baxter state. While the study on superhydrophobic microchannels are focused mainly in maximizing the friction reduction effects and maintaining the stability of the air pockets, less attention has been given to characterizing the microchannel friction under a metastable state, where partial flooding of the micro-textures may be present, and under heated conditions, where the air pockets are trapped between the micro-textures. In order to quantify the frictional characteristics, microchannels with micron-sized trenches on the side walls were fabricated and tested under varying inlet pressures and heating conditions. By measuring the hydrodynamic resistance and comparing with numerical simulations, results suggest that (1) the air-water interface behaves close to a no-slip boundary condition, (2) friction becomes insensitive to the wetting degree once the micro-trenches become highly wetting, (3) the fully wetted micro-trench may be beneficial over the de-wetted ones in order to achieve friction reduction effects and (4) heating the micro-trenches to induce a highly de-wetting state may actually be detrimental to the microchannel flow due the excessive growth of the air layer. As part of the future work to characterize heat transfer in superhydrophobic microchannels, a rectangular microchannel with microheaters embedded close to the side walls was fabricated and the corresponding heat transfer rates were measured through dual fluorescence thermometry. Results suggested that significant heat is lost through the environment despite the high thermal resistance of the microchannel material. An extra insulation is suggested prior to characterizing the convective heat transfer coefficients in the superhydrophobic microchannel flow.Mechanical Engineerin

Evaluation of automotive weatherstrip by coupled analysis of fluid-structure-noise interaction

Automotive weatherstrip plays a major role in isolating the passenger compartment from water, dust and noise, etc. Among them, the wind noise through weatherstrip is the most severe factor making the passenger uncomfortable. Weatherstrip should be in contact between the door and the body frame, and sufficient contact area is needed to minimize the wind noise through weatherstrip. But there are several factors that make it difficult to ensure sufficient contact area. First, weatherstrip rubber deteriorates as time goes by and residual stress in the rubber becomes relaxed which results in the decrease of the contact area. Second, the gap between the door and the body increases due to pressure difference at high speed. In order to predict and reduce wind noise through weatherstrip, nonlinear behaviour of rubber at high speed and he effect of rubber deformation to wind noise should both be analyzed. In the paper, rubber deformation with time is obtained by hyperelastic and viscoelastic analyses, while the gap between the door and the body frame of the vehicle going at a high speed was predicted by the coupled analysis, Fluid-Structure Interaction (FSI). And also Statistical Energy Analysis (SEA) calculates the amount of wind noise numerically caused by rubber deformation under high speed condition