Effect of Angelica gigas Nakai extract on hepatic damage in rats

Purpose: To determine the antioxidant and hepatoprotective effects of decursin and decursinol angelate (D/DA) isolated from Angelica gigas Nakai (AGN).Methods: The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity of D/DA was assessed in a rat model using blood tests, western blotting, and histopathological analyses to identify the pharmaceutical effects of D/DA on liver enzymes and liver morphology.Results: The DPPH scavenging activity of D/DA was 47.11 μg/mL. Administration of D/DA to carbon tetrachloride (CCl4)-treated rats led to a decrease (13.59 %) in the total liver mass of control rats. Decursin and decursinol angelate also lowered the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), but increased the concentrations of antioxidant enzymes in the liver, including catalase (CAT) and glutathione peroxidase (GPx). Histological examination revealed that D/DA also reduced hepatocellular damage in the rats.Conclusion: D/DA from AGN has significant anti-hepatotoxic and antioxidant activities, and thus, is a potential herbal drug for treating liver damage. Keywords: Decursin, Decursinol angelate, Antihepatotoxicity, Antioxidant, Angelica gigas Naka

Effect Of Changes In The Korean Accounting Environment On The Productivity Of Accounting Firms

To investigate how changes in the accounting environment in Korea affect firm productivity, this study analyzes productivity by firm size and labor type from 2000 to 2014, using a Cobb–Douglas production function. We find that (1) the greater the management advisory (tax) revenue, the greater the total revenue in large (small) accounting firms; and (2) marginal revenue is greatest for partners, followed by certified public accountants and general employees. In particular, partners’ contribution to large accounting firms improved after 2007, whereas general employees made a significant positive contribution to total revenue before 2007

Mechanisms of Cross-protection by Influenza Virus M2-based Vaccines

Current influenza virus vaccines are based on strain-specific surface glycoprotein hemagglutinin (HA) antigens and effective only when the predicted vaccine strains and circulating viruses are well-matched. The current strategy of influenza vaccination does not prevent the pandemic outbreaks and protection efficacy is reduced or ineffective if mutant strains emerge. It is of high priority to develop effective vaccines and vaccination strategies conferring a broad range of cross protection. The extracellular domain of M2 (M2e) is highly conserved among human influenza A viruses and has been utilized to develop new vaccines inducing cross protection against different subtypes of influenza A virus. However, immune mechanisms of cross protection by M2e-based vaccines still remain to be fully elucidated. Here, we review immune correlates and mechanisms conferring cross protection by M2e-based vaccines. Molecular and cellular immune components that are known to be involved in M2 immune-mediated protection include antibodies, B cells, T cells, alveolar macrophages, Fc receptors, complements, and natural killer cells. Better understanding of protective mechanisms by immune responses induced by M2e vaccination will help facilitate development of broadly cross protective vaccines against influenza A virus

Dysfunction of 67-kDa Laminin Receptor Disrupts BBB Integrity via Impaired Dystrophin/AQP4 Complex and p38 MAPK/VEGF Activation Following Status Epilepticus

Status epilepticus (SE, a prolonged seizure activity) impairs brain-blood barrier (BBB) integrity, which results in secondary complications following SE. The non-integrin 67-kDa laminin receptor (67-kDa LR) plays a role in cell adherence to laminin (a major glycoprotein component in basement membrane), and participates laminin-mediated signaling pathways including p38 mitogen-activated protein kinase (p38 MAPK). Thus, we investigated the role of 67-kDa LR in SE-induced vasogenic edema formation in the rat piriform cortex (PC). SE diminished 67-kDa LR expression, but increased laminin expression, in endothelial cells accompanied by the reduced SMI-71 (a rat BBB barrier marker) expression. Astroglial 67-kDa LR expression was also reduced in the PC due to massive astroglial loss. 67-kDa LR neutralization led to serum extravasation in the PC concomitant with the reduced SMI-71 expression. 67-kDa LR neutralization also decreased expressions of dystrophin and aquaporin-4 (AQP4). In addition, it increased p38 MAPK phosphorylation and expressions of vascular endothelial growth factor (VEGF), laminin and endothelial nitric oxide synthase (eNOS), which were abrogated by SB202190, a p38 MAPK inhibitor. Therefore, our findings indicate that 67-kDa LR dysfunction may disrupt dystrophin-AQP4 complex, which would evoke vasogenic edema formation and subsequent laminin over-expression via activating p38 MAPK/VEGF axis

Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis

This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in the constituent patterns between KIOM-MA and KIOM-MA128. Our results suggest that both KIOM-MA and KIOM-MA128 have potential for therapeutic reagent for the treatment of AD, and further, the efficacy is significantly enhanced by L. acidophilus fermentation via increases in its indicator molecule

A Planetary Companion to the Intermediate-Mass Giant HD 100655

A precise radial velocity survey conducted by a Korean-Japanese planet search program revealed a planetary companion around the intermediate-mass clump giant HD 100655. The radial velocity of the star exhibits a periodic Keplerian variation with a period, semi-amplitude and eccentricity of 157.57 d, 35.2 m s^-1 and 0.085, respectively. Adopting an estimated stellar mass of 2.4 M_Sun, we confirmed the presence of a planetary companion with a semi-major axis of 0.76 AU and a minimum mass of 1.7 M_Jup. The planet is the lowest-mass planet yet discovered around clump giants with masses greater than 1.9 M_Sun.Comment: 17 pages, 8 figures, accepted for publication in PAS

Korean-Japanese Planet Search Program: Substellar Companions around Intermediate-Mass Giants

A Korean-Japanese planet search program has been carried out using the 1.8m telescope at Bohyunsan Optical Astronomy Observatory (BOAO) in Korea, and the 1.88m telescope at Okayama Astrophysical Observatory (OAO) in Japan to search for planets around intermediate-mass giant stars. The program aims to show the properties of planetary systems around such stars by precise Doppler survey of about 190 G or K type giants together with collaborative surveys of the East-Asian Planet Search Network. So far, we detected two substellar companions around massive intermediate-mass giants in the Korean-Japanese planet search program. One is a brown dwarf-mass companion with 37.6 $M_{\mathrm{J}}$ orbiting a giant HD 119445 with 3.9 $M_{\odot}$, which is the most massive brown dwarf companion among those found around intermediate-mass giants. The other is a planetary companion with 1.8 $M_{\mathrm{J}}$ orbiting a giant star with 2.4 $M_{\odot}$, which is the lowest-mass planetary companion among those detected around giant stars with $>$ 1.9 $M_{\odot}$. Plotting these systems on companion mass vs. stellar mass diagram, there seem to exist two unpopulated regions of substellar companions around giants with 1.5--3 $M_{\odot}$ and planetary companions orbiting giants with 2.4--4 $M_{\odot}$. The existence of these possible unpopulated regions supports a current characteristic view that more massive substellar companions tend to exist around more massive stars.Comment: 8 pages, 3 figures, Part of PlanetsbeyondMS/2010 proceedings http://arxiv.org/html/1011.660