This network represents the differentially expressed genes regulated in thrombin transactivation of the TGFBR1.

<p>The functions of this network include biological processes, molecular functions and cellular component. The color of the nodes indicates the query protein and its first shell of interactions. Protein nodes which are enlarged indicates the availability of 3D protein structure information. The colored lines between the nodes indicated the query protein-protein interactions. The known interactions is a light blue (from curated database) or pink (experimentally determined) lines between the proteins. The predicted interactions use green (gene neighborhood), red (gene fusion) and dark blue (gene co-occurrence) lines. The yellow represents text mining, the black represent co-expression and the purple lines represent protein homology.</p

Genes most up regulated and down regulated by thrombin transactivation of the TGFBR1 in vascular smooth muscle cells.

<p>Genes most up regulated and down regulated by thrombin transactivation of the TGFBR1 in vascular smooth muscle cells.</p

The top 50 gene ontology terms in the analysis of genes expressed in thrombin transactivation of both the EGFR and TGFBR1.

<p>The top 50 gene ontology terms in the analysis of genes expressed in thrombin transactivation of both the EGFR and TGFBR1.</p

List of genes and respective fold change of expression associated with gene ontology term cardiovascular development.

<p>The differentially expressed genes with no fold change presented in the table did not reach the statistical significance cut off (<i>P<</i>0.01 and Log2FC>0.7)</p

Depicted is the Venn diagram showing the differentially expressed genes of each of the treatments.

<p>Thrombin transactivation of the EGFR (209 genes), thrombin transactivation of the TGFBR1 (177 genes) and thrombin transactivation of both EGFR and TGFBR1 (212 genes).</p

The top 50 gene ontology terms in the analysis of genes expressed in thrombin transactivation of the EGFR.

<p>The top 50 gene ontology terms in the analysis of genes expressed in thrombin transactivation of the EGFR.</p

Genes most up regulated and down regulated by thrombin transactivation of the TGFBR1 and EGFR in vascular smooth muscle cells.

<p>Genes most up regulated and down regulated by thrombin transactivation of the TGFBR1 and EGFR in vascular smooth muscle cells.</p

This network represents the differentially expressed genes regulated in thrombin transactivation of both the EGFR and TGFBR1.

<p>The functions of this network include biological processes, molecular functions and cellular component. The color of the nodes indicates the query protein and its first shell of interactions. Protein nodes which are enlarged indicates the availability of 3D protein structure information. The colored lines between the nodes indicated the query protein-protein interactions. The known interactions is a light blue (from curated database) or pink (experimentally determined) lines between the proteins. The predicted interactions use green (gene neighborhood), red (gene fusion) and dark blue (gene co-occurrence) lines. The yellow represents text mining, the black represent co-expression and the purple lines represent protein homology.</p

Depicted is the Venn diagram showing the genes up and down regulated by each of the transactivation dependent signalling pathways.

<p>209 genes are differentially expressed via thrombin transactivation of the EGFR (80 upregulated and 129 down regulated) and 177 genes are differentially expressed via thrombin transactivation of the TGFBR1 (26 upregulated and 141 down regulated).</p

Genes most up regulated and down regulated by thrombin transactivation of the EGFR in vascular smooth muscle cells.

<p>Genes most up regulated and down regulated by thrombin transactivation of the EGFR in vascular smooth muscle cells.</p