684 research outputs found
A catalog of 120 NGC open star clusters
A sample of 145 JHK--2MASS observations of NGC open star clusters is studied,
of which 132 have never been studied before. Twelve are classified as non-open
clusters and 13 are re-estimated self-consistently, after applying the same
methods in order to compare and calibrate our reduction procedures. The
fundamental and structural parameters of the 120 new open clusters studied here
are derived using color-magnitude diagrams of JHK Near-IR photometry with the
fitting of solar metallicity isochrones. We provide here, for the first time, a
catalog of the main parameters for these 120 open clusters, namely, diameter,
distance, reddening and age.Comment: 18 pages, 7 figures, Published in Journal of The Korean Astronomical
Society 44: 1-11, 2011 Februar
The role of augurin in the hypothalamo-pituitary-adrenal axis and the regulation of food intake
Novel secreted peptides represent an important field of research because delineation of their
function affords new insights into the pathophysiological processes causing disease, and
provides opportunities for the development of pharmacological therapies. Augurin is a recently
identified secreted peptide of unknown function expressed in the central nervous system (CNS),
pituitary, and several endocrine tissues. Because of its expression pattern I hypothesised that
augurin may be involved in the neuroendocrine system. I therefore investigated the effects of
central injection of augurin on the hypothalamo-pituitary axes and food intake in male Wistar
rats.
Intracerebroventricular (ICV) or intraparaventricular nucleus (iPVN) injection of augurin
increased plasma adrenocorticotrophic hormone (ACTH) and corticosterone levels compared
with vehicle-injected controls. Augurin also increased the release of corticotrophin releasing
hormone (CRH) from hypothalamic explants, and pre-treatment with a CRH receptor antagonist
in vivo prevented the rise in ACTH and corticosterone caused by ICV augurin, suggesting
activation the hypothalamo-pituitary-adrenal (HPA) axis via by the release of CRH from
neurons in the PVN. In addition to stimulating the HPA axis, iPVN injection of augurin at the
start of either the light or dark phase caused a robust increase in food intake.
To assess whether augurin might have a physiological role in the regulation of the HPA axis or
food intake, I investigated its endogenous distribution in the rat CNS using
immunohistochemistry and in situ hybridisation histochemistry. Augurin positive neurons were
present in several regions of the CNS including the hypothalamus and the dorsal vagal complex
of the brainstem, a distribution consistent with a possible role in neuroendocrine function.
Augurin is therefore anatomically positioned to play a role in the hypothalamic regulation of the
HPA axis and food intake.
While the data presented suggest a novel role for augurin, these are preliminary studies.
Currently, little is known about the physiology of the augurin system. Further characterisation
of the neuroanatomy, identification of receptors, and the development of receptor agonists and
antagonists would provide further data on the physiological role of augurin, and on the potential
therapeutic benefits of manipulating the augurin system
A rapid and convergent synthesis of the integrastatin core
The tetracyclic core of the integrastatin natural products has
been prepared in a convergent and rapidmanner. Our strategy
relies upon a palladium(II)-catalyzed oxidative cyclization to
form the central [3.3.1]-dioxabicycle of the natural product
core. Overall, the core has been completed in only 4 linear
steps from known compounds
Aryne Acyl-Alkylation in the General and Convergent Synthesis of Benzannulated Macrolactone Natural Products: An Enantioselective Synthesis of (−)-Curvularin
A general approach for the synthesis of benzannulated macrolactone natural products utilizing an aryne acyl-alkylation reaction is described. Toward this end, the total syntheses of the natural products (−)-curvularin, curvulin, and (−)-diplodialide C are reported. Furthermore, the aryne insertion technology has enabled the rapid conversion of simple diplodialide natural products to curvularin, thereby connecting these two biosynthetically distinct classes of compounds via synthetic methods
Creating Imagined and Real Communities Through Classroom Activities
Young learners have strong negative associations with formal learning and uninteresting content. Furthermore, it is challenging for students to speak English outside the classroom in a TL removed context. To rectify this situation, the presenter will demonstrate some engaging and interesting activities to encourage student participation and make learning fun
Radial velocities and metallicities from infrared Ca II triplet spectroscopy of open clusters: Berkeley 26, Berkeley 70, NGC 1798, and NGC 2266
Context: Open clusters are ideal test particles for studying the formation
and evolution of the Galactic disk. However, the number of clusters with
information about their radial velocities and chemical compositions remains
largely insufficient. Aims: We attempt to increase the number of open clusters
with determinations of radial velocities and metallicities from spectroscopy.
Methods: We acquired medium-resolution spectra (R~8000) in the region of the
infrared Ca II triplet lines (~8500\AA) for several stars in four open clusters
with the long-slit spectrograph IDS at the 2.5m Isaac Newton Telescope, Roque
de los Muchachos Observatory, Spain. Radial velocities were obtained by
cross-correlating the observed spectra with those of two template stars. We
used the relationships available in the literature between the strength of
infrared Ca II lines and metallicities to derive the metal content of each
cluster. Results: We provide the first spectroscopic determinations of radial
velocities and metallicities for the open clusters Berkeley 26, Berkeley 70,
NGC 1798, and NGC 2266. We obtain =6812, -157, 210, and
-1615 km s for Berkeley 26, Berkeley 70, NGC 1798, and NGC 2266,
respectively. For Berkeley 26 we derive a metallicity of [Fe/H]=-0.350.17
dex. Berkeley 70 has a solar metallicity of [Fe/H]=-0.010.14 dex, while
NGC 1798 has a slightly lower metal content of [Fe/H]=-0.120.07 dex.
Finally, we derive a metallicity of [Fe/H]=-0.380.06 dex for NGC 2266.Comment: 7 pages, 5 figures, accepted for publication in A&
- …