1 research outputs found
Friction-Mediated Dynamic Disordering of Phospholipid Membrane by Mechanical Motions of Photoresponsive Molecular Glue: Activation of Ion Permeation
A water-soluble photoresponsive molecular glue, Azo-<sup>18</sup>Glue, consisting of a photochromic azobenzene core and two
adhesive
dendritic wedges with a total of 18 peripheral guanidinium ion (Gu<sup>+</sup>) pendants tightly adheres to the surface of a phospholipid
membrane, even in buffer, via a multivalent salt-bridge formation
with phosphate anions. A photomechanical motion of adhering Azo-<sup>18</sup>Glue possibly gives rise to dynamic structural disordering
of the phospholipid membrane and activates transmembrane ion permeation.
In sharp contrast, no activation of ion permeation results when poorly
adhesive Azo-<sup>6</sup>Glue carrying only six Gu<sup>+</sup> pendants
is used in place of Azo-<sup>18</sup>Glue