中高年の運動活動が心身面に及ぼす影響について

The purpose of this study was to examine the effect of middle-advanced age\u27s exercise on psychological and physical aspects. Subjects in this study were 8 males and 5 females. Their average ages were 58.0 ± 8.2. They were asked to perform aerobic exercise for 30 minutes and stretching about 30 minutes before and after aerobic exercise. They exercised two times per a week for three months. As a result, the following main effects were detected. 1) Psychological aspects (POMS and motivation of exercise behavior) changed to a positive profile. 2) All physical abilities were not enhanced by this aerobic exercise program, but at least the physical abilities before this program were maintained. 3) Amounts of triglyceride (TG) and HDL cholesterol (HDL-C) showed a significant decrease (p < .05)

アーチェリーにおける標的の視覚的補助がエイミングの注視運動に及ぼす影響

The purpose of this study was to investigate the influence of an assisting mark, The a cross (a vertical line and a horizon line), which was put on the target to stabilize aiming in archery. Subjects in this study were nine male and one female university archers. They were required to aim at the center of the target for 5 sec. as in archery competition. Dependent valuables were frequency, angle of eye movement and eye fixation time. This study assumed that the presense of a cross on the target makes it easier to aim than under normal conditions. Hypotheses were as follows : (1) Frequency of eye movement for the cross condition is less than that for normal condition in aiming. (2) Eye fixation time for the cross condition is longer than that for normal condition in aiming. (3) Angle of eye movement on cross line condition is smaller than that for normal condition in aiming. The results of analysis indicated that the three hypothesizes were supported and that subjects focused attention on the center of the target when the cross was present on the target

最大筋力発揮イメージ想起時の瞳孔反応について

The purpose of this study was to examine pupillary responses in imagery of maximum muscle strength. Subjects in this study were male and female physical education students (N = 21). They were divided into three groups on scores of imagery as "performing" in VMI test III. These groups were ; (a) imagery training (IM), (b) imagery and performance training (IMP), and (c) control (C). The task was maximum muscle strength by grip. Two different pupil sizes, measured during imaging from in resting and during performing from in imaging, were measured as dependent valuables. The results indicated the following : 1) The pupil size measured during imaging from in resting was the lowest in post test of IMP. 2) The pupil size measured during performing from in imaging was the hightest in post test of IMP. 3) In both pre- and post tests of the pupil size which was taken during performance from in imaging was not equal by each trial. These findings seem to suggest that imagery and performance training will debilitate pupillary responses

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target