7 research outputs found

    The role of Notch in tumorigenesis: oncogene or tumour suppressor?

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    Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor

    Protein Truncation as a Common Denominator of Human Neurodegenerative Foldopathies

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    Neurotoxin Mechanisms and Processes Relevant to Parkinson’s Disease: An Update

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    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

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