9 research outputs found
Direct medical costs in children with rotavirus and non-rotavirus diarrhea admitted to a pediatric intensive care unit and high dependency unit in Delhi
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Comparison of coliform contamination in non-municipal waters consumed by the Mennonite versus the non-Mennonite rural populations
No full textIncidence Analyses and Space-Time Cluster Detection of Hepatitis C in Fujian Province of China from 2006 to 2010
No full textBurden of Diarrhea, Hospitalization and Mortality Due to Cryptosporidial Infections in Indian Children
No full textDiagnosis of viral gastroenteritis in children: interpretation of real-time PCR results and relation to clinical symptoms
No full textThe sweet spot: defining virus-sialic acid interactions
No full textViral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus-glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications
