19 research outputs found

    Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal

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    Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed “click” reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodynamic profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail

    Scanning electron microscope-based stereo analysis

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    In this paper we present a novel technique to analyze stereo images generated from a SEM. The two main features of this technique are that it uses a binary linear programming approach to set up and solve the correspondence problem and that it uses constraints based on the physics of SEM image formation. Binary linear programming is a powerful tool with which to tackle constrained optimization problems, especially in cases that involve matching between one data set and another. We have also analyzed the process of SEM image formation, and present constraints that are useful in solving the stereo correspondence problem. This technique has been tested on many images. Results for a few wafers are included here.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46055/1/138_2005_Article_BF01211849.pd
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