自治体福祉行政におけるモニタリングシステムの実証的研究 : 介護保険制度を中心に

取得学位:博士（社会環境学）, 授与番号:博士甲第86号, 授与年月日:2007年3月22日, 授与大学:金沢大学, 論文審査委員長:井上, 英夫, 論文審査委員:横山, 壽一 / 石田, 道彦 / 前田, 達男 / 足立, 研

Complication of Chronic Eosinophilic Pneumonia in an Elderly Patient with Sjögren Syndrome

An 81-year-old Japanese male with primary Sjögren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefore, the present case is extremely unique in that the patientʼs condition was complicated with CEP. A diagnosis of advanced gallbladder cancer was made in the patientʼs clinical course, suggesting the advisability of a whole-body workup in cases of pSS, especially in elderly patients

障害者の地域生活と地域福祉実践の可能性に関する一研究

今日のわが国では、地域共生社会の構築の必要性が称えられ、これまで以上に障害者の地域生活の実現に向けた取組みと、地域福祉の推進が必要とされるようになってきている。しかし現実には、なかなかこれが進んでいない。そこで本稿では、これに具体的な実現の方向性と可能性を探るため、山形県の二つの調査結果を取り上げ、調査主体の了解の基に二次分析を試みた。その分析結果のデータから、可能と思われる要素として地域福祉推進に関しては、あらゆる人々が参加可能となるような条件整備に関するニーズの把握と、これの実現に向けた実践の必要性が確認された。施設利用者の地域移行に関しては、外出と地域住民とのコミュニケーションの必要性が示唆され、そのための支援のあり方や、地域における受け入れのあり方などの必要性が示唆された。こうした結果から具体的な実践課題として、意思決定の内容の検討、地域共生社会の実践手法、障害者も含めた「地域像」の形成、中川地区に代表される成功事例の研修などが考えられた

New mouse model of acute adult T‐cell leukemia generated by transplantation of AKT, BCLxL, and HBZ‐transduced T cells

Adult T‐cell leukemia/lymphoma (ATL) develops in human T‐cell leukemia virus type 1 (HTLV‐1) carriers. Although the HTLV‐1‐encoded HBZ gene is critically involved, HBZ alone is insufficient and additional, cooperative “hits” are required for the development of ATL. Candidate cooperative hits are being defined, but methods to rapidly explore their roles in ATL development in collaboration with HBZ are lacking. Here, we present a new mouse model of acute type ATL that can be generated rapidly by transplanting in vitro‐induced T cells that have been retrovirally transduced with HBZ and two cooperative genes, BCLxL and AKT, into mice. Co‐transduction of HBZ and BCLxL/AKT allowed these T cells to grow in vitro in the absence of cytokines (Flt3‐ligand and interleukin‐7), which did not occur with any two‐gene combination. Although transplanted T cells were a mixture of cells transduced with different combinations of the genes, tumors that developed in mice were composed of HBZ/BCLxL/AKT triply transduced T cells, showing the synergistic effect of the three genes. The genetic/epigenetic landscape of ATL has only recently been elucidated, and the roles of additional “hits” in ATL pathogenesis remain to be explored. Our model provides a versatile tool to examine the roles of these hits, in collaboration with HBZ, in the development of acute ATL