Lieb Mode in a Quasi One-Dimensional Bose-Einstein Condensate of Atoms

We calculate the dispersion relation associated with a solitary wave in a quasi-one-dimensional Bose-Einstein condensate of atoms confined in a harmonic, cylindrical trap in the limit of weak and strong interactions. In both cases, the dispersion relation is linear for long wavelength excitations and terminates at the point where the group velocity vanishes. We also calculate the dispersion relation of sound waves in both limits of weak and strong coupling.Comment: 4 pages, 2 ps figures, RevTe

Vortex Rings and Lieb Modes in a Cylindrical Bose-Einstein Condensate

We present a calculation of a solitary wave propagating along a cylindrical Bose-Einstein trap, which is found to be a hybrid of a one-dimensional (1D) soliton and a three-dimensional (3D) vortex ring. The calculated energy-momentum dispersion exhibits characteristics similar to those of a mode proposed sometime ago by Lieb within a 1D model, as well as some rotonlike features.Comment: 4 pages, 4 figure

Quantum Resistive Transition in Type II Superconductors under Magnetic Field

It is shown that, within a Ginzburg-Landau (GL) formalism, the superconducting fluctuation is insulating at zero temperature even if the fluctuation dynamics is metallic (dissipative). Based on this fact, the low temperature behavior of the $H_{c2}$-line and the resistivity curves near a zero temperature transition are discussed. In particular, it is pointed out that the neglect of quantum fluctuations in data analysis of the dc resistivity may lead to an under-estimation of the $H_{c2}$ values near zero temperature.Comment: 7 page

The Infrared Imaging Spectrograph (IRIS) for TMT: the ADC optical design

We present the current optical design for the IRIS Atmospheric Dispersion Corrector (ADC). The ADC is designed for residual dispersions less than ~1 mas across a given passband at elevations of 25 degrees. Since the last report, the area of the IRIS Imager has increased by a factor of four, and the pupil size has increased from 75 to 90mm, both of which contribute to challenges with the design. Several considerations have led to the current design: residual dispersion, amount of introduced distortion, glass transmission, glass availability, and pupil displacement. In particular, it was found that there are significant distortions that appear (two different components) that can lead to image blur over long exposures. Also, pupil displacement increases the wave front error at the imager focus. We discuss these considerations, discuss the compromises, and present the final design choice and expected performance

News in the classification of WHO 2022 bladder tumors

The fifth-edition of World Health Organization (WHO) Classification of Tumors series for urinary and male genital tract tumors has been published, six years later the fourth-edition. In these years, new treatment approaches have been implemented and new molecular data on urological cancers are known. Morphology remains the groundwork for taxonomy of the urinary tract tumors. However, a molecular approach to classification of urothelial carcinomas and the management of selected neoplasms with new therapeutic modalities such as immunotherapy are emerging. More data are needed for the application of these advances in routine pathology practice and patient management. The 2022 World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs represents an update in classification on urinary tract tumors. It also offers new insights with regards to the grading of heterogeneous non-invasive urothelial neoplasms, the definition of inverted neoplasms, the grading of invasive urothelial carcinomas, the diversity of morphological appearance of urothelial carcinomas, the definition of precursor lesions and the lineage of differentiation of the tumors

Effect of spatial variations of superconducting gap on suppression of the transition temperature by impurities

We calculate correction to the critical temperature of a dirty superconductor, which results from the local variations of the gap function near impurity sites. This correction is of the order of T_c/E_F and becomes important for short-coherence length superconductors. It generally reduces a pair-breaking effect. In s-wave superconductors small amounts of nonmagnetic impurities can increase the transition temperature.Comment: 5 pages, ReVTE

A theorem on the absence of phase transitions in one-dimensional growth models with onsite periodic potentials

We rigorously prove that a wide class of one-dimensional growth models with onsite periodic potential, such as the discrete sine-Gordon model, have no phase transition at any temperature $T>0$. The proof relies on the spectral analysis of the transfer operator associated to the models. We show that this operator is Hilbert-Schmidt and that its maximum eigenvalue is an analytic function of temperature.Comment: 6 pages, no figures, submitted to J Phys A: Math Ge

Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo

AbstractSpecific inhibitors for cathepsin L and cathepsin S have been developed with the help of computer-graphic modeling based on the stereo-structure. The common fragment, N-(L-trans-carbamoyloxyrane-2-carbonyl)-phenylalanine-dimethylamide, is required for specific inhibition of cathepsin L. Seven novel inhibitors of the cathepsin L inhibitor Katunuma (CLIK) specifically inhibited cathepsin L at a concentration of 10−7 M in vitro, while almost no inhibition of cathepsins B, C, S and K was observed. Four of the CLIKs are stable, and showed highly selective inhibition for hepatic cathepsin L in vivo. One of the CLIK inhibitors contains an aldehyde group, and specifically inhibits cathepsin S at 10−7 M in vitro

Population density, water supply, and the risk of dengue fever in Vietnam: cohort study and spatial analysis.

BACKGROUND: Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We analysed the interaction between human population density and lack of tap water as a cause of dengue fever outbreaks with the aim of identifying geographic areas at highest risk. METHODS AND FINDINGS: We conducted an individual-level cohort study in a population of 75,000 geo-referenced households in Vietnam over the course of two epidemics, on the basis of dengue hospital admissions (n = 3,013). We applied space-time scan statistics and mathematical models to confirm the findings. We identified a surprisingly narrow range of critical human population densities between around 3,000 to 7,000 people/km² prone to dengue outbreaks. In the study area, this population density was typical of villages and some peri-urban areas. Scan statistics showed that areas with a high population density or adequate water supply did not experience severe outbreaks. The risk of dengue was higher in rural than in urban areas, largely explained by lack of piped water supply, and in human population densities more often falling within the critical range. Mathematical modeling suggests that simple assumptions regarding area-level vector/host ratios may explain the occurrence of outbreaks. CONCLUSIONS: Rural areas may contribute at least as much to the dissemination of dengue fever as cities. Improving water supply and vector control in areas with a human population density critical for dengue transmission could increase the efficiency of control efforts. Please see later in the article for the Editors' Summary

Dynamical Effective Medium Theory for Quantum Spins and Multipoles

A dynamical effective medium theory is presented for quantum spins and higher multipoles such as quadrupole moments. The theory is a generalization of the spherical model approximation for the Ising model, and is accurate up to O(1/z_n) where z_n is the number of interacting neighbors. The polarization function is optimized under the condition that it be diagonal in site indices. With use of auxiliary fields and path integrals, the theory is flexibly applied to quantum spins and higher multipoles with many interacting neighbors. A Kondo-type screening of each spin is proposed for systems with extreme quantum fluctuations but without conduction electrons.Comment: 16 pages, 3 Postscript figure