47 research outputs found
Excess-entropy scaling in supercooled binary mixtures
Supercooled liquids near the glass transition show remarkable non-Arrhenius transport phenomena, whose origin is yet to be clarified. Here, the authors use GPU molecular dynamics simulations for various binary mixtures in the supercooled regime to show the validity of a quasiuniversal excess-entropy scaling relation for viscosity and diffusion
Explaining why simple liquids are quasi-universal
It has been known for a long time that many simple liquids have surprisingly
similar structure as quantified, e.g., by the radial distribution function. A
much more recent realization is that the dynamics are also very similar for a
number of systems with quite different pair potentials. Systems with such
non-trivial similarities are generally referred to as "quasi-universal". From
the fact that the exponentially repulsive pair potential has strong virial
potential-energy correlations in the low-temperature part of its thermodynamic
phase diagram, we here show that a liquid is quasi-universal if its pair
potential can be written approximately as a sum of exponential terms with
numerically large prefactors. Based on evidence from the literature we moreover
conjecture the converse, i.e., that quasi-universality only applies for systems
with this property
Inhaled Corticosteroids in Patients with Chronic Obstructive Pulmonary Disease and Risk of Acquiring Streptococcus pneumoniae Infection. A Multiregional Epidemiological Study
Background: Inhaled corticosteroids (ICS) are associated with an increased risk of clinical pneumonia among patients with chronic obstructive pulmonary disease (COPD). It is unknown whether the risk of microbiologically verified pneumonia such as pneumococcal pneumonia is increased in ICS users. Methods: The study population consists of all COPD patients followed in outpatient clinics in eastern Denmark during 2010-2017. ICS use was categorized into four categories based on accumulated use. A Cox proportional hazard regression model was used adjusting for age, body mass index, sex, airflow limitation, use of oral corticosteroids, smoking, and year of cohort entry. A propensity score matched analysis was performed for sensitivity analyses. Findings:  A total of 21,438 patients were included. Five hundred and eighty-two (2.6%) patients acquired a positive lower airway tract sample with S. pneumoniae during follow-up. In the multivariable analysis ICS-use was associated with a dose-dependent risk of S. pneumoniae as follows: low ICS dose: HR 1.11, 95% CI 0.84 to 1.45, p = 0.5; moderate ICS dose: HR 1.47, 95% CI 1.13 to 1.90, p = 0.004; high ICS dose: HR 1.77, 95% CI 1.38 to 2.29, p < 0.0001, compared to no ICS use. Sensitivity analyses confirmed these results. Interpretation: Use of ICS in patients with severe COPD was associated with an increased and dose-dependent risk of acquiring S. pneumoniae, but only for moderate and high dose. Caution should be taken when administering high dose of ICS to patients with COPD. Low dose of ICS seemed not to carry this risk
Density-scaling exponents and virial potential-energy correlation coefficients for the (2n, n) Lennard-Jones system
This paper investigates the relation between the density-scaling exponent
and the virial potential-energy correlation coefficient at several
thermodynamic state points in three dimensions for the generalized
Lennard-Jones (LJ) system for , as well as for the standard
LJ system in two, three, and four dimensions. The state points studied
include many low-density states at which the virial potential-energy
correlations are not strong. For these state points we find the roughly linear
relation in dimensions. This result is discussed in
light of the approximate "extended inverse power law" description of
generalized LJ potentials [N. P. Bailey et al., J. Chem. Phys. 129, 184508
(2008)]. In the plot of versus there is in all cases a transition
around , above which starts to decrease as
approaches unity. This is consistent with the fact that for , a limit that is approached at high densities and/or
temperatures at which the repulsive term dominates the physics