11 research outputs found
Gianotti Crosti syndrome associated with transfusion acquired hepatitis B virus infection in a patient of sickle cell anemia
Case Report - Azathioprine-induced shock: An uncommon, unpredictable and potentially fatal adverse effect of azathioprine
A 60 year-old male was initiated on azathioprine 50 mg/day for airborne
contact dermatitis. As the patient showed a satisfactory response to
this initial therapy, azathioprine dose was escalated to 100 mg/day
after two weeks. However, the patient started feeling unwell from that
day onwards and developed features of azathioprine-induced shock
leading to discontinuation of azathioprine. Within the next 24 hours,
there was complete resolution of nausea, malaise, abdominal pain,
hypotensive episodes, fever and diarrhea in a pattern similar to that
in which they had appeared. Rechallenge with a single dose of
azathioprine (50 mg), resulted in the recurrence of nausea, vomiting
and the characteristic fever spike four hours later. His blood pressure
showed a marginal fall from 130/80 to 100/70 mm Hg. However, a
clinically manifest episode of hypotension did not develop. This case
is being reported for its rarity and clinical interest