110 research outputs found

    Structural aging of human neurons is the opposite of the changes in schizophrenia

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    Human mentality develops with age and is altered in psychiatric disorders, though their underlying mechanism is unknown. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the anterior cingulate cortex from eight schizophrenia and eight control cases. The distribution profiles of neurite curvature of the control cases showed a trend depending on their age, resulting in an age-correlated decrease in the standard deviation of neurite curvature (Pearson's r = -0.80, p = 0.018). In contrast to the control cases, the schizophrenia cases deviate upward from this correlation, exhibiting a 60% higher neurite curvature compared with the controls (p = 7.8 x 10^(-4)). The neurite curvature also showed a correlation with a hallucination score (Pearson's r = 0.80, p = 1.8 x 10^(-4)), indicating that neurite structure is relevant to brain function. We suggest that neurite curvature plays a pivotal role in brain aging and can be used as a hallmark to exploit a novel treatment of schizophrenia. This nano-CT paper is the result of our decade-long analysis and is unprecedented in terms of number of cases.Comment: 24 pages, 5 figures. arXiv admin note: text overlap with arXiv:2007.0021

    Recent Results from LHD Experiment with Emphasis on Relation to Theory from Experimentalist’s View

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    he Large Helical Device (LHD) has been extending an operational regime of net-current free plasmas towardsthe fusion relevant condition with taking advantage of a net current-free heliotron concept and employing a superconducting coil system. Heating capability has exceeded 10 MW and the central ion and electron temperatureshave reached 7 and 10 keV, respectively. The maximum value of β and pulse length have been extended to 3.2% and 150 s, respectively. Many encouraging physical findings have been obtained. Topics from recent experiments, which should be emphasized from the aspect of theoretical approaches, are reviewed. Those are (1) Prominent features in the inward shifted configuration, i.e., mitigation of an ideal interchange mode in the configuration with magnetic hill, and confinement improvement due to suppression of both anomalous and neoclassical transport, (2) Demonstration ofbifurcation of radial electric field and associated formation of an internal transport barrier, and (3) Dynamics of magnetic islands and clarification of the role of separatrix

    Paleomagnetism of Miocene Rocks in the Western Area of Baragoi, Northern Kenya

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    A total of 22 reliable paleomagnetic data has been obtained from Miocene rocks in this area. The magnetic polarity sequence is divided into six magneto-zones, which are tentatively correlated with the geomagnetic reversal time scale. The Kenyapithecus horizon is assigned to a normal epoch in the period between 14 Ma and 12 Ma. The VGPs obtained from this area show the deviations in the direction of the "far-sided and right-handed" effect from the geographical pole

    Paleomagnetism of Miocene Rocks in the Western Area of Baragoi, Northern Kenya

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    Strontium concentrations in saline lake waters in the Dry Valleys region of Southern Victoria Land, Antarctica

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    The Sr concentrations of saline lake waters collected from the Dry Valleys region of Victoria Land were determined and the Sr/Ca ratios were evaluated. These waters have various Sr/Ca ratios ranging from 0.0 to 4.56×(10)^. It was observed that the Sr/Ca ratios of inland lake waters were smaller than those of the lakes near the Ross Sea. On the basis of the Sr/Ca ratios the origin of lake waters in the Dry Valleys region is summarized as follows : 1) The water in Lake Fryxell was originated from evaporated seawater under frigid conditions, because the Sr/Ca ratio of the water, about 3 to 4×(10)^, is similar to that of evaporated seawater from which halite is deposited. This water may have been formed by mixing of the evaporated seawater with glacial meltwater. It is likely that the water in Lake Bonney was also formed in a similar manner to that of Lake Fryxell. 2) The water in Lake Vanda was originated from glacial meltwater containing dissolved marine evaporites. The evaporites such as calcite and gypsum in the valley may have been formed under frigid conditions as delineated by T. G. THOMPSON and K. H. NELSON (Am. J. Sci., 254,227,1956). 3) The water in the Labyrinth area was probably originated from the dissolution of air-borne salts by glacial meltwater and snowfall and the waters drived from fresh water-basalt interactions
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