Evaluation of Kinetic Effects of Baicalein in Different Breast Cancer Cell Lines

The aim of this study was to compare the antiproliferative effects of baicalein which is a flavonoide on MCF-7 and MDA-MB-231 cell line. The experiments were carried out with the evaluation of the parameters. Including cell viability, cell index, mitotic index, labelling index and apoptotic index. With the cell viability test, IC50 concentrations of baicalein for MCF-7 and MDA-MB-231 cells were determined as 10 µM and 30 µM, respectively and these concentrations were used in all experiments. The results showed that the IC50 concentrations decreased the values of cell viability, cell index, mitotic index and labelling index and increased the apoptotic index value for both cell types. These decreases and increases are statistically significant (p<0.01). In addition, curves of the graphs obtained from the xCelligence Real-Time Cell Analysis System showed that baicalein has cytoskeletal effects on MCF-7 cells and cytostatic effects on MDA-MB-231 cells. The results obtained from this study suggest that baicalein can be used in patients with luminal A and triple negative breast cancer in the clinic by supporting the future studies due to its antiproliferative effects on MCF-7 and MDA-MB-231 cells