Clinical experience with the Bicarbon heart valve prosthesis

BACGROUND: We have previously reported mid-term results of a study, which ended in January 2000, on the Bicarbon valve. The study concluded that the valve showed excellent clinical results, associated with a low incidence of valve-related complications. In the present study, the same patients were prospectively followed for an additional 5 years. METHODS: Forty-four patients had aortic valve replacement (AVR), 48 had mitral valve replacement (MVR), and 13 had both aortic and mitral valve replacement (DVR). The mean age of the 105 patients was 61.2 ± 11.3 years. The mean follow-up was 6.1 ± 1.9 years with a cumulative follow-up of 616 patient-years. RESULTS: There were 5 early deaths (4.7%: 4 in the AVR group and 1 in the MVR group) and 21 late deaths (3.4%/patient-year: 5 valve related deaths and 16 valve unrelated deaths). Survival at 8 years was 75.2 ± 7.0% in the AVR group, 76.6 ± 6.2% in the MVR group, and 55.4 ± 16.1% in the DVR group. The linearized incidence of thrombo-embolic complications, hemorrhagic complications, and paravalvular leaks in all patients was 0.65 ± 1.48%, 0.81 ± 1.69%, and 0.16 ± 0.54%/patient-year respectively. No other complications were observed. CONCLUSION: The Bicarbon prosthetic heart valve has shown excellent long-term clinical results, associated with a low incidence of valve-related complications

Rhizopusサイボウヘキヨウカイコウソルイニカンスルケンキュウ

京都大学0048新制・論文博士農学博士乙第3257号論農博第682号新制||農||235(附属図書館)学位論文||S52||N920(農学部図書室)5055UT51-52-A857(主査)教授 山田 秀明, 教授 栃倉 辰六郎, 教授 駒野 徹学位規則第5条第2項該当Kyoto UniversityDA

COMPARATIVE STUDY ON PRIMARY STRUCTURES OF TWO LIPASES FROM GEOTRICHUM CANDIDUM

Geotrichum(G.) candidum produces two extracellular lipases I and II, the lipase I being the predominant component. The lipase I and II cDNAs were cloned, and their nucleotide sequences were determined. The nucleotide sequences included the N- and Cterminal amino acid sequences and the partial amino acid sequences of the lipases. The mature lipases I and II were of the same length, their overall identity being 84%, Furthermore, four Cys residues were completely conserved, which may participate in the formation of disulfide bridges. A homology search indicated that the G. candidum lipases and Candida cylindracea lipase are homologous enzymes, and that they are members of the cholinesterase family