Macroscopic Interferences of Neutrino Waves

Interference phenomena of neutrinos are studied. High energy neutrino in T2K near detector and low energy neutrino in KamLAND are possible experiments that could show macroscopic interferences of neutrino waves. In both experiments interference patterns may give new insights on the absolute value of the neutrino mass.Comment: 12 pages, 2 figure

Principle and Robotic Applications of Conical Scanning Method

We have proposed a surrounding environmental recognition method using conical scanning distance measurement for mobile robots. The conical scanning method has a high robustness against ambient light noise and its calculation cost is low. This report describes the principle of this method and the two implementations. The first application is the quadrupedal wheeled robot. The robot can recognize a stair in sight, approach to it and climb. A second application is the indoor-outdoor wheeled mobile robot. The robot can recognize its position and obstacles on floor from information of a laser range finder and a 3D ToF camera. The validity of this method was confirmed by these robotic applications

Estimation of Drug-effect in Use of Multi-tracer Autoradioqraphy - Effect of S-Adenosyl-L-Methionoie on Postischemic Brain Injury in Rat -

開始ページ、終了ページ: 冊子体のページ付

Sex of muscle stem cells does not influence potency for cardiac cell therapy

We have previously shown that populations of skeletal muscle-derived stem cells (MDSCs) exhibit sexbased differences for skeletal muscle and bone repair, with female cells demonstrating superior engrafting abilities to males in skeletal muscle while male cells differentiating more robustly toward the osteogenic and chondrogenic lineages. In this study, we tested the hypothesis that the therapeutic capacity of MDSCs transplanted into myocardium is influenced by sex of donor MDSCs or recipient. Male and female MDSCs isolated from the skeletal muscle of 3-week-old mice were transplanted into recipient male or female dystrophin-deficient (mdx) hearts or into the hearts of male SCID mice following acute myocardial infarction. In the mdx model, no difference was seen in engraftment or blood vessel formation based on donor cell or recipient sex. In the infarction model, MDSC-transplanted hearts showed higher postinfarction angiogenesis, less myocardial scar formation, and improved cardiac function compared to vehicle controls. However, sex of donor MDSCs had no significant effects on engraftment, angiogenesis, and cardiac function. VEGF expression, a potent angiogenic factor, was similar between male and female MDSCs. Our results suggest that donor MDSC or recipient sex has no significant effect on the efficiency of MDSC-triggered myocardial engraftment or regeneration following cardiac injury. The ability of the MDSCs to improve cardiac regeneration and repair through promotion of angiogenesis without differentiation into the cardiac lineage may have contributed to the lack of sex difference observed in these models. Copyright © 2009 Cognizant Comm. Corp

Appraisal of Local Farmers’ Practices on Land Management for a Guideline of Agricultural Development in the Sahel Zone of Niger

In order to bridge a gap between research results and farmers’ needs for agricultural development in the Sahel, we made a study of traditional agricultural production systems derived from what we understood about indigenous knowledge (IK) of Sahelian farmers. The study was conducted in the western part of Niger, West Africa. IK was gathered from interviews among several villages of different generations. Then impartiality was verified. We obtained detailed information on land management and topographical features of farmland and devised a thorough local classification system. Statistical results showed that the obtained information was not significantly different among villages and generations. This result brought recognition that IK was a shared knowledge among local farmers in the study area. The study classified in detail a farmland that was directly or indirectly affected by household economy, the potential of natural resources like organic matter, and the relationship between agriculturalist and pastoralist. Understanding this context for soil fertility management at the village level makes it possible to assess the situation more appropriately than simply looking at actual practices, thereby helping to identify a problematic issue that concerns local farmers

The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy

Background: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies results from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2). We determined whether TNNT2 mutations cause cardiomyopathies by altering cTnT function or quantity; whether the severity of DCM is related to the ratio of mutant to wildtype cTnT; whether Ca2+ desensitization occurs in DCM; and whether absence of cTnT impairs early embryonic cardiogenesis. Methods and Findings: We ablated Tnnt2 to produce heterozygous Tnnt2+/ mice, and crossbreeding produced homozygous null Tnnt2-/-embryos. We also generated transgenic mice overexpressing wildtype (TGWT) or DCM mutant (TGK210Δ) Tnnt2. Crossbreeding produced mice lacking one allele of Tnnt2, but carrying wildtype (Tnnt2+/-/TGWT) or mutant (Tnnt2+/-/TGK210Δ) transgenes. Tnnt2+/-mice relative to wildtype had significantly reduced transcript (0.82 ± 0.06 [SD] vs. 1.00 ± 0.12 arbitrary units; p = 0.025), but not protein (1.01 ± 0.20 vs. 1.00 ± 0.13 arbitrary units; p = 0.44). Tnnt2+/-mice had normal hearts (histology, mass, left ventricular end diastolic diameter [LVEDD], fractional shortening [FS]). Moreover, whereas Tnnt2+/-/ TGK210Δ mice had severe DCM, TGK210Δ mice had only mild DCM (FS 18 ± 4 vs. 29 ± 7%; p < 0.01). The difference in severity of DCM may be attributable to a greater ratio of mutant to wildtype Tnnt2 transcript in Tnnt2+/-/TGK210Δ relative to TGK210Δ mice (2.42±0.08, p = 0.03). Tnnt2+/-/TGK210Δ muscle showed Ca2+ desensitization (pCa50 = 5.34 ± 0.08 vs. 5.58 ± 0.03 at sarcomere length 1.9 μm. p<0.01), but no difference in maximum force generation. Day 9.5 Tnnt2-/-embryos had normally looped hearts, but thin ventricular walls, large pericardial effusions, noncontractile hearts, and severely disorganized sarcomeres. Conclusions: Absence of one Tnnt2 allele leads to a mild deficit in transcript but not protein, leading to a normal cardiac phenotype. DCM results from abnormal function of a mutant protein, which is associated with myocyte Ca2+ desensitization. The severity of DCM depends on the ratio of mutant to wildtype Tnnt2 transcript. cTnT is essential for sarcomere formation, but normal embryonic heart looping occurs without contractile activity. © 2008 Ahmad et al