Theoretical characterisation of spheroidal PbSe/PbS Core/Shell colloidal quantum dot heterostructures

Nanocrystal quantum dots (NQDs) show great promise in the advancement of the field of photovoltaics. While the maximum efficiency of conventional solar cell (SC) devices is limited to ∼ 31% (Shockley-Queisser limit), devices based on NQDs may attain a maximal thermodynamic efficiency of 42% through the exploitation of multiple exciton generation (MEG). In this process, several electron-hole pairs are created by the absorption of a single high energy photon, as opposed to the single excitons created in conventional solar cell devices. IV-VI semiconductor nanocrystals (PbS, PbSe) are of particular interest as candidates for the exploitation of MEG due to the narrow band gap, high confinement energies, and long radiative carrier lifetimes observed in these systems. In order to realise the full potential of MEG devices, full characterisation of the optoelectronic properties of the underlying nanoparticles is desirable. While the size-dependent properties of NQDs are well understood, the effects of NQD shape are less so. This thesis investigates the effect of ellipticity on the optoelectronic properties associated with spheroidal NQDs. To this end, a four-band, anisotropic, and radially variant k · p system Hamiltonian is expanded in a planewave basis in order to calculate single-particle eigenenergies and eigenfunctions of colloidal PbSe/PbS core/shell heterogeneous NQDs of varying ellipticity. Many-body effects are accounted for via a full configuration interaction (CI) Hamiltonian, the basis of which is comprised of the single-particle states. Exci-tonic and bi-excitonic corrections are then found by mixing of the basis states. In this manner, such diverse electronic and optical properties as quasi-particle binding energies, momentum matrix elements, and charge carrier lifetimes, both radiative and non-radiative, may be predicted

Co- Creating a Blended learning Curriculum in Transition to Higher Education: A Student Viewpoint.

Involving students in the design and development of their curriculum is well established in Higher Education but comes with challenges and concerns for both the staff and students. This is not a simple concept and understanding more about the experiences of the student co-creators supports others in developing this aspect of curriculum design. This small scale project uses the individual and collective voices of five second year students who worked with one programme team to co-create a transition module to support new learners entering university. The study explores the co-creation experience and the student’s response to the feedback their co-created curriculum received when it was run for the first time. The study was designed to consider if co-creation of a module was beneficial to the students involved in its co-creation. The findings explored issues in relation to the experience, the actual design of the materials and how this could be developed. The students enjoyed the co-creation, felt appreciated and listened to and felt that this was a positive learning experience. They realised how difficult it is to please everybody and gained a much better appreciation of building learning experiences for others to use. The research highlights the fact that with regards to curriculum development within universities that students should be involved in co-creation as they have an understanding of the requirements of learning form a student perspective. Whilst student satisfaction cannot be necessarily be measured directly, the anecdotal comments from students involved in this project as they graduate are the values they place on the opportunities afforded to them

Pulmonary rehabilitation in idiopathic pulmonary fibrosis and COPD: a propensity matched real-world study

BACKGROUND: The adherence to and clinical efficacy of pulmonary rehabilitation in idiopathic pulmonary fibrosis (IPF), particularly in comparison to people with chronic obstructive pulmonary disease (COPD), remains uncertain. The objectives of this real-world study were to compare the responses of patients with IPF with a matched group of patients with COPD undergoing the same supervised, outpatient pulmonary rehabilitation program, and to determine whether pulmonary rehabilitation is associated with survival in IPF. RESEARCH QUESTION: Do people with IPF improve to the same extent with pulmonary rehabilitation as a matched group of individuals with COPD, and are non-completion of and/or non-response to pulmonary rehabilitation associated with one-year all-cause mortality in IPF? STUDY DESIGN AND METHODS: Using propensity score matching, 163 patients with IPF were matched 1:1 with a control group of 163 patients with COPD referred to pulmonary rehabilitation. We compared between-group pulmonary rehabilitation completion rates and response. Survival status in the IPF cohort was recorded over one-year following pulmonary rehabilitation discharge. Cox proportional-hazards regression explored the association between pulmonary rehabilitation status and all-cause mortality. RESULTS: Similar pulmonary rehabilitation completion rates (IPF: 69%; COPD: 63%; p=0.24) and improvements in exercise response were observed in both groups with no significant mean (95% confidence interval (CI)) between-group differences in incremental shuttle walk (ISW) change (2 (-18 to 22) meters). Pulmonary rehabilitation non-completion (hazard ratio (HR) (95%CI) 5.62 (2.24 to 14.08)) and non-response (HR (95%CI) 3.91 (1.54 to 9.93)) were independently associated with increased one-year all-cause mortality in IPF. INTERPRETATION: Compared with a matched group of patients with COPD, this real-word study demonstrates that patients with IPF have similar completion rates and magnitude of response to pulmonary rehabilitation. In IPF, non-completion of and non-response to pulmonary rehabilitation were associated with increased all-cause mortality. These data reinforce the benefits of pulmonary rehabilitation in patients with IPF

Change in gait speed and adverse outcomes in patients with idiopathic pulmonary fibrosis: a prospective cohort study.

BACKGROUND AND OBJECTIVE: Gait speed is associated with survival in individuals with idiopathic pulmonary fibrosis (IPF). The extent to which four-metre gait speed (4MGS) decline predicts adverse outcome in IPF remains unclear. We aimed to examine longitudinal 4MGS change and identify a cut-point associated with adverse outcome. METHODS: In a prospective cohort study, we recruited 132 individuals newly diagnosed with IPF and measured 4MGS change over 6 months. Death/first hospitalization at 6 months were composite outcome events. Complete data (paired 4MGS plus index event) were available in 85 participants; missing 4MGS data were addressed using multiple imputation. Receiver-Operating Curve plots identified a 4MGS change cut-point. Cox proportional-hazard regression assessed the relationship between 4MGS change and time to event. RESULTS: 4MGS declined over 6 months (mean [95% CI] change: -0.05 [-0.09 to -0.01] m/s; p = 0.02). A decline of 0.07 m/s or more in 4MGS over 6 months had better discrimination for the index event than change in 6-minute walk distance, forced vital capacity, Composite Physiologic Index or Gender Age Physiology index. Kaplan-Meier curves demonstrated a significant difference in time to event between 4MGS groups (substantial decline: >-0.07 m/s versus minor decline/improvers: ≤-0.07 m/s; p = 0.007). Those with substantial decline had an increased risk of hospitalization/death (adjusted hazard ratio [95% CI] 4.61 [1.23-15.83]). Similar results were observed in multiple imputation analysis. CONCLUSION: In newly diagnosed IPF, a substantial 4MGS decline over 6 months is associated with shorter time to hospitalization/death at 6 months. 4MGS change has potential as a surrogate endpoint for interventions aimed at modifying hospitalization/death