93 research outputs found
Evolution of active and polar photospheric magnetic fields during the rise of Cycle 24 compared to previous cycles
The evolution of the photospheric magnetic field during the declining phase
and minimum of Cycle 23 and the recent rise of Cycle 24 are compared with the
behavior during previous cycles. We used longitudinal full-disk magnetograms
from the NSO's three magnetographs at Kitt Peak, the Synoptic Optical Long-term
Investigations of the Sun (SOLIS) Vector Spectro-Magnetograph (VSM), the
Spectromagnetograph and the 512-Channel Magnetograph instruments, and
longitudinal full-disk magnetograms from the Mt. Wilson 150-foot tower. We
analyzed 37 years of observations from these two observatories that have been
observing daily, weather permitting, since 1974, offering an opportunity to
study the evolving relationship between the active region and polar fields in
some detail over several solar cycles. It is found that the annual averages of
a proxy for the active region poloidal magnetic field strength, the magnetic
field strength of the high-latitude poleward streams, and the time derivative
of the polar field strength are all well correlated in each hemisphere. These
results are based on statistically significant cyclical patterns in the active
region fields and are consistent with the Babcock-Leighton phenomenological
model for the solar activity cycle. There was more hemispheric asymmetry in the
activity level, as measured by total and maximum active region flux, during
late Cycle 23 (after around 2004), when the southern hemisphere was more
active, and Cycle 24 up to the present, when the northern hemisphere has been
more active, than at any other time since 1974. The active region net proxy
poloidal fields effectively disappeared in both hemispheres around 2004, and
the polar fields did not become significantly stronger after this time. We see
evidence that the process of Cycle 24 field reversal has begun at both poles.Comment: Accepted for publication in Solar Physic
The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion
Mucin 5B (MUC5B) has an essential role in mucociliary clearance that protects the pulmonary airways. Accordingly, knowledge of MUC5B structure and its interactions with itself and other proteins is critical to better understand airway mucus biology and improve the management of lung diseases such as asthma, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). The role of an N-terminal multimerization domain in the supramolecular organization of MUC5B has been previously described, but less is known about its C-terminal dimerization domain. Here, using cryogenic electron microscopy (cryo-EM) and small-angle X-ray scattering (SAXS) analyses of recombinant disulfide-linked dimeric MUC5B dimerization domain we identified an asymmetric, elongated twisted structure, with a double globular base. We found that the dimerization domain is more resistant to disruption than the multimerization domain suggesting the twisted structure of the dimerization domain confers additional stability to MUC5B polymers. Size-exclusion chromatography-multiangle light scattering (SEC-MALS), SPR-based biophysical analyses and microscale thermophoresis of the dimerization domain disclosed no further assembly, but did reveal reversible, calciumdependent interactions between the dimerization and multimerization domains that were most active at acidic pH, suggesting that these domains have a role in MUC5B intragranular organization. In summary, our results suggest a role for the C-terminal dimerization domain of MUC5B in compaction of mucin chains during granular packaging via interactions with the N-terminal multimerization domain. Our findings further suggest that the less stable multimerization domain provides a potential target for mucin depolymerization to remove mucus plugs in COPD and other lung pathologies
Solar Intranetwork Magnetic Elements: bipolar flux appearance
The current study aims to quantify characteristic features of bipolar flux
appearance of solar intranetwork (IN) magnetic elements. To attack such a
problem, we use the Narrow-band Filter Imager (NFI) magnetograms from the Solar
Optical Telescope (SOT) on board \emph{Hinode}; these data are from quiet and
an enhanced network areas. Cluster emergence of mixed polarities and IN
ephemeral regions (ERs) are the most conspicuous forms of bipolar flux
appearance within the network. Each of the clusters is characterized by a few
well-developed ERs that are partially or fully co-aligned in magnetic axis
orientation. On average, the sampled IN ERs have total maximum unsigned flux of
several 10^{17} Mx, separation of 3-4 arcsec, and a lifetime of 10-15 minutes.
The smallest IN ERs have a maximum unsigned flux of several 10^{16} Mx,
separations less than 1 arcsec, and lifetimes as short as 5 minutes. Most IN
ERs exhibit a rotation of their magnetic axis of more than 10 degrees during
flux emergence. Peculiar flux appearance, e.g., bipole shrinkage followed by
growth or the reverse, is not unusual. A few examples show repeated
shrinkage-growth or growth-shrinkage, like magnetic floats in the dynamic
photosphere. The observed bipolar behavior seems to carry rich information on
magneto-convection in the sub-photospheric layer.Comment: 26 pages, 14 figure
The Drosophila melanogaster Genetic Reference Panel
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics
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