An investigation of the relationship between BOLD and perfusion signal changes during epileptic generalised spike wave activity

In pathological conditions interpretation of functional magnetic resonance imaging (fMRI) results can be difficult. This is due to a reliance on the assumed coupling between neuronal activity and changes in cerebral blood flow (CBF) and oxygenation. We wanted to investigate the coupling between blood oxygen level dependant contrast (BOLD) and CBF time courses in epilepsy patients with generalised spike wave activity (GSW) to better understand the underlying mechanisms behind the EEG-fMRI signal changes observed, especially in regions of negative BOLD response (NBR). Four patients with frequent GSW were scanned with simultaneous electroencephalographic (EEG)-fMRI with BOLD and arterial spin labeling (ASL) sequences. We examined the relationship between simultaneous CBF and BOLD measurements by looking at the correlation of the two signals in terms of percentage signal change on a voxel-by-voxel basis. This method is not reliant on coincident activation. BOLD and CBF were positively correlated in patients with epilepsy during background EEG activity and GSW. The subject average value of the ΔCBF/ΔBOLD slope lay between +19 and +36 and also showed spatial variation which could indicate areas with altered vascular response. There was not a significant difference between ΔCBF/ΔBOLD during GSW, suggesting that neurovascular coupling to BOLD signal is generally maintained between states and, in particular, within areas of NBR

Enhancements of gravity wave amplitudes at midlatitudes during sudden stratospheric warmings in 2008

Abstract. Two minor and one major stratospheric warming happened in January and February 2008 when the polar vortex was shifted toward midlatitudes. The analysis of temperature profiles from radiosondes in Payerne (Switzerland) during this period reveals an enhancement of gravity wave amplitudes between 25 and 30 km altitude especially during the two minor warmings around 20 January and 1 February. Increases of gravity wave amplitudes in the mid-stratosphere are associated with a strong tropopause jet and the presence of the polar vortex edge over Switzerland. </jats:p

Timed Parity Games: Complexity and Robustness

We consider two-player games played in real time on game structures with clocks where the objectives of players are described using parity conditions. The games are \emph{concurrent} in that at each turn, both players independently propose a time delay and an action, and the action with the shorter delay is chosen. To prevent a player from winning by blocking time, we restrict each player to play strategies that ensure that the player cannot be responsible for causing a zeno run. First, we present an efficient reduction of these games to \emph{turn-based} (i.e., not concurrent) \emph{finite-state} (i.e., untimed) parity games. Our reduction improves the best known complexity for solving timed parity games. Moreover, the rich class of algorithms for classical parity games can now be applied to timed parity games. The states of the resulting game are based on clock regions of the original game, and the state space of the finite game is linear in the size of the region graph. Second, we consider two restricted classes of strategies for the player that represents the controller in a real-time synthesis problem, namely, \emph{limit-robust} and \emph{bounded-robust} winning strategies. Using a limit-robust winning strategy, the controller cannot choose an exact real-valued time delay but must allow for some nonzero jitter in each of its actions. If there is a given lower bound on the jitter, then the strategy is bounded-robust winning. We show that exact strategies are more powerful than limit-robust strategies, which are more powerful than bounded-robust winning strategies for any bound. For both kinds of robust strategies, we present efficient reductions to standard timed automaton games. These reductions provide algorithms for the synthesis of robust real-time controllers

The efficacy of recombinant thrombopoietin in murine and nonhuman primate models for radiation-induced myelosuppression and stem cell transplantation

Radiation-induced pancytopenia proved to be a suitable model system in mice and rhesus monkeys for studying thrombopoietin (TPO) target cell range and efficacy. TPO was highly effective in rhesus monkeys exposed to the mid-lethal dose of 5 Gy (300 kV x-rays) TBI, a model in which it alleviated thrombocytopenia, promoted red cell reconstitution, accelerated reconstitution of immature CD34+ bone marrow cells, and potentiated the response to growth factors such as GM-CSF and G-CSF. In contrast to the results in the 5 Gy TBI model, TPO was ineffective following transplantation of limited numbers of autologous bone marrow or highly purified stem cells in monkeys conditioned with 8 Gy TBI. In the 5 Gy model, a single dose of TPO augmented by GM-CSF 24 h after TBI was effective in preventing thrombocytopenia. The strong erythropoietic stimulation may result in iron depletion, and TPO treatment should be accompanied by monitoring of iron status. This preclinical evaluation thus identified TPO as a potential major therapeutic agent for counteracting radiation-induced pancytopenia and demonstrated pronounced stimulatory effects on the reconstitution of immature CD34+ hemopoietic cells with multilineage potential. The latter observation explains the potentiation of the hematopoietic responses to G-CSF and GM-CSF when administered concomitantly. It also predicts the effective use of TPO to accelerate reconstitution of immature hematopoietic cells as well as possible synergistic effects in vivo with various other growth factors acting on immature stem cells and their direct lineage-committed progeny. The finding that a single dose of TPO might be sufficient for a clinically significant response emphasizes its potency and is of practical relevance. The heterogeneity of the TPO response encountered in the various models used for evaluation points to multiple mechanisms operating on the TPO response and heterogeneity of its target cells. Mechanistic mouse studies made apparent that the response of multilineage cells shortly after TBI to a single administration of TPO is quantitatively more important for optimal efficacy than the lineage-restricted response obtained at later intervals after TBI and emphasized the importance of a relatively high dose of TPO to overcome initial c-mpl-mediated clearance. Further elucidation of mechanisms determining efficacy might very well result in a further improvement, e.g., following transplantation of limited numbers of stem cells. Adverse effects of TPO administration to myelosuppressed or stem cell transplanted experimental animals were not observed

Conductance anomalies and the extended Anderson model for nearly perfect quantum wires

Anomalies near the conductance threshold of nearly perfect semiconductor quantum wires are explained in terms of singlet and triplet resonances of conduction electrons with a single weakly-bound electron in the wire. This is shown to be a universal effect for a wide range of situations in which the effective single-electron confinement is weak. The robustness of this generic behavior is investigated numerically for a wide range of shapes and sizes of cylindrical wires with a bulge. The dependence on gate voltage, source-drain voltage and magnetic field is discussed within the framework of an extended Hubbard model. This model is mapped onto an extended Anderson model, which in the limit of low temperatures is expected to lead to Kondo resonance physics and pronounced many-body effects

Conductance renormalization and conductivity of a multi-subband Tomonaga-Luttinger model

We studied the conductance renormalization and conductivity of multi-subband Tomonaga-Luttinger models with inter-subband interactions. We found that, as in single-band systems, the conductance of a multi-subband system with an arbitrary number of subbands is not renormalized due to interaction between electrons. We derived a formula for the conductivity in multi-subband models. We applied it to a simplified case and found that inter-subband interaction enhances the conductivity, which is contrary to the intra-subband repulsive interaction, and that the conductivity is further enhanced for a larger number of subbands.Comment: 12 pages, no figures. to be published in Physical Review B as a brief repor

Space Vehicle Terrestrial Environment Design Requirements Guidelines

The terrestrial environment is an important driver of space vehicle structural, control, and thermal system design. NASA is currently in the process of producing an update to an earlier Terrestrial Environment Guidelines for Aerospace Vehicle Design and Development Handbook. This paper addresses the contents of this updated handbook, with special emphasis on new material being included in the areas of atmospheric thermodynamic models, wind dynamics, atmospheric composition, atmospheric electricity, cloud phenomena, atmospheric extremes, and sea state. In addition, the respective engineering design elements are discussed relative to terrestrial environment inputs that require consideration. Specific lessons learned that have contributed to the advancements made in the application and awareness of terrestrial environment inputs for aerospace engineering applications are presented

Novel Synthesis and High Pressure Behavior of Na0.3CoO2 x 1.3 H2O and Related Phases

We have prepared powder samples of NaxCoO2 x yH2O using a new synthesis route. Superconductivity was observed in Na0.3CoO2 x 1.3H2O between 4 and 5K as indicated by the magnetic susceptibility. The bulk compressibilities of Na0.3CoO2 x 1.3H2O, Na0.3CoO2 x 0.6H2O and Na0.3CoO2 were determined using a diamond anvil cell and synchrotron powder diffraction. Chemical changes occurring under pressure when using different pressure transmitting media are discussed and further transport measurements are advocated.Comment: 7 pages, 4 figures, PRrapid submitte

A closer look at the uncertainty relation of position and momentum

We consider particles prepared by the von Neumann-L\"uders projection. For those particles the standard deviation of the momentum is discussed. We show that infinite standard deviations are not exceptions but rather typical. A necessary and sufficient condition for finite standard deviations is given. Finally, a new uncertainty relation is derived and it is shown that the latter cannot be improved.Comment: 3 pages, introduction shortened, content unchange