Automatic Small Bowel Tumor Diagnosis by Using Multi-Scale Wavelet-Based Analysis in Wireless Capsule Endoscopy Images

BACKGROUND: Wireless capsule endoscopy has been introduced as an innovative, non-invasive diagnostic technique for evaluation of the gastrointestinal tract, reaching places where conventional endoscopy is unable to. However, the output of this technique is an 8 hours video, whose analysis by the expert physician is very time consuming. Thus, a computer assisted diagnosis tool to help the physicians to evaluate CE exams faster and more accurately is an important technical challenge and an excellent economical opportunity. METHOD: The set of features proposed in this paper to code textural information is based on statistical modeling of second order textural measures extracted from co-occurrence matrices. To cope with both joint and marginal non-Gaussianity of second order textural measures, higher order moments are used. These statistical moments are taken from the two-dimensional color-scale feature space, where two different scales are considered. Second and higher order moments of textural measures are computed from the co-occurrence matrices computed from images synthesized by the inverse wavelet transform of the wavelet transform containing only the selected scales for the three color channels. The dimensionality of the data is reduced by using Principal Component Analysis. RESULTS: The proposed textural features are then used as the input of a classifier based on artificial neural networks. Classification performances of 93.1% specificity and 93.9% sensitivity are achieved on real data. These promising results open the path towards a deeper study regarding the applicability of this algorithm in computer aided diagnosis systems to assist physicians in their clinical practice

Long-term variability of the optical spectra of NGC 4151: II. Evolution of the broad Ha and Hb emission-line profiles

Results of the long-term (11 years, from 1996 to 2006) H$\alpha$ and H$\beta$ line variations of the active galactic nucleus of NGC 4151 are presented. High quality spectra (S/N>50 and R~8A) of H$\alpha$ and H$\beta$ were investigated. We analyzed line profile variations during monitoring period. Comparing the line profiles of H$\alpha$ and H$\beta$, we studied different details (bumps, absorption features) in the line profiles. The variations of the different H$\alpha$ and H$\beta$ line profile segments have been investigated. Also, we analyzed the Balmer decrement for whole line and for line segments. We found that the line profiles were strongly changing during the monitoring period, showing blue and red asymmetries. This indicates a complex BLR geometry of NGC 4151 with, at least, three kinematically distinct regions: one that contributes to the blue line wing, one to the line core and one to the red line wing. Such variation can be caused by an accelerating outflow starting very close to the black hole, where the red part may come from the region {closer to the black hole than the blue part, which is coming} from the region having the highest outflow velocities. Taking into account the fact that the BLR of NGC 4151 has a complex geometry (probably affected by an outflow) and that a portion of the broad line emission seems to have not a pure photoionization origin, one can ask the question whether the study of the BLR by reverberation mapping may be valid in the case of this galaxy.Comment: 24 pages, 18 figures, accepted for publications in A&

The impact of physical exercise on the circulating levels of BDNF and NT 4/5: A review

(1) Background: One mechanism through which physical activity (PA) provides benefit is by triggering activity at a molecular level, where neurotrophins (NTs) are known to play an important role. However, the expression of the circulating levels of neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4/5), in response to exercise, is not fully understood. Therefore, the aim was to provide an updated overview on the neurotrophin (NT) variation levels of BDNF and NT-4/5 as a consequence of a long-term aerobic exercise intervention, and to understand and describe whether the upregulation of circulating NT levels is a result of neurotrophic factors produced and released from the brain, and/or from neurotrophic secreting peripheral organs. (2) Methods: The articles were collected from PubMed, SPORTDiscus, Web of Science, MEDLINE, and Embase. Data were analyzed through a narrative synthesis. (3) Results: 30 articles studied humans who performed training protocols that ranged from 4 to 48 weeks; 22 articles studied rodents with an intervention period that ranged from 4 to 64 weeks. (4) Conclusions: There is no unanimity between the upregulation of BDNF in humans; conversely, concerning both BDNF and NT-4/5 in animal models, the results are heterogeneous. Whilst BDNF upregulation appears to be in relative agreement, NT-4/5 seems to display contradictory and inconsistent conclusions