65 research outputs found
Neurogenesis induced by seizures in the dentate gyrus is not related to mossy fiber sprouting but is age dependent in developing rats
On the relevance of prolonged convulsive status epilepticus in animals to the etiology and neurobiology of human temporal lobe epilepsy
The pilocarpine model of epilepsy in mice
Purpose: To characterize the acute and chronic behavioral, electrographic and histologic effects of sustained seizures induced by pilocarpine in mice.Methods: After status epilepticus, the surviving animals were continuously monitored for 24 h/day for less than or equal to 120 days. the brains were processed by using neo-Timm and Nissl stains.Results: the first spontaneous seizures occurred between 4 and 42 days after status epilepticus. the mean ''seizure-silent period'' lasted for 14.4 +/- 11.9 days. During the chronic phase, recurrent spontaneous seizures were observed 1-5 times per animal per week and were associated with sprouting in the supragranular layer of the dentate gyrus.Conclusions: Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice.UNIFESP, EPM, RUA BOTUCATU 862, BR-04023900 São Paulo, BRAZILUNIFESP, EPM, RUA BOTUCATU 862, BR-04023900 São Paulo, BRAZILWeb of Scienc
Growth-associated Protein 43 Expression in Hippocampal Molecular Layer of Chronic Epileptic Rats Treated with Cycloheximide
Correlations Between Granule Cell Dispersion, Mossy Fiber Sprouting, and Hippocampal Cell Loss in Temporal Lobe Epilepsy
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