447 research outputs found
Radiation hydrodynamics simulations of wide-angle outflows from super-critical accretion disks around black holes
By performing two-dimensional radiation hydrodynamics simulations with large
computational domain of 5000 Schwarzschild radius, we revealed that wide-angle
outflow is launched via the radiation force from the super-critical accretion
flows around black holes. The angular size of the outflow, of which the radial
velocity (v_r) is over the escape velocity (v_esc), increases with an increase
of the distance from the black hole. As a result, the mass is blown away with
speed of v_r > v_esc in all direction except for the very vicinity of the
equatorial plane, theta=0-85^circ, where theta is the polar angle. The mass
ejected from the outer boundary per unit time by the outflow is larger than the
mass accretion rate onto the black hole, ~150L_Edd/c^2, where L_Edd and c are
the Eddington luminosity and the speed of light. Kinetic power of such
wide-angle high-velocity outflow is comparable to the photon luminosity and is
a few times larger than the Eddington luminosity. This corresponds to
~10^39-10^40 erg/s for the stellar mass black holes. Our model consistent with
the observations of shock excited bubbles observed in some ultra-luminous X-ray
sources (ULXs), supporting a hypothesis that ULXs are powered by the
super-critical accretion onto stellar mass black holes.Comment: 9 pages, 8 figures, accepted for publication in PAS
Synergistic defect in 60S ribosomal subunit assembly caused by a mutation of Rrs1p, a ribosomal protein L11-binding protein, and 3′-extension of 5S rRNA in Saccharomyces cerevisiae
Rrs1p, a ribosomal protein L11-binding protein, has an essential role in biogenesis of 60S ribosomal subunits. We obtained conditionally synthetic lethal allele with the rrs1-5 mutation and determined that the mutation is in REX1, which encodes an exonuclease. The highly conserved leucine at 305 was substituted with tryptophan in rex1-1. The rex1-1 allele resulted in 3′-extended 5S rRNA. Polysome analysis revealed that rex1-1 and rrs1-5 caused a synergistic defect in the assembly of 60S ribosomal subunits. In vivo and in vitro binding assays indicate that Rrs1p interacts with the ribosomal protein L5–5S rRNA complex. The rrs1-5 mutation weakens the interaction between Rrs1p with both L5 and L11. These data suggest that the assembly of L5–5S rRNA on 60S ribosomal subunits coordinates with assembly of L11 via Rrs1p
臨床用CTを用いた上腕骨大結節の領域別骨梁微細構造解析
BACKGROUND:
In arthroscopic surgery, the suture anchor technique has become popular for rotator cuff repair. Preoperative evaluation of the bone microstructure is of utmost importance because, especially in elderly patients, osteoporotic changes may cause anchor pullout, which results in failure of rotator cuff repair. Many groups have reported humeral microstructural analysis; however, most studies were experiments using porcine specimens or human cadavers. In this study, we used multidetector row computed tomography to successfully perform in vivo evaluation of the bone microstructure of the humeral greater tuberosity in patients with rotator cuff tears.
METHODS:
Ten patients were examined. Regions of interest were defined in six quadrants of the greater tuberosity (medial, lateral, and far lateral rows of the anterior and posterior areas). The local bone mineral density and the trabecular microstructural parameters, including the mean bone volume to total volume (BV/TV), trabecular thickness, trabecular separation, and structure model index (SMI), were measured using bone analysis software.
RESULTS:
The BV/TV of the posteromedial region was highest and the SMI of the posteromedial region was lowest. These findings suggest that the bone quality of the posteromedial portion is the highest within the greater tuberosity.
CONCLUSION:
Because the bone quality may be correlated with the pullout strength of suture anchors, our method can help to understand the individual and regional variance in bone quality and may lead to the creation of personalized surgical protocols.博士(医学)・乙第1360号・平成27年5月28日© 2014 Sakamoto et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
The Effects of Environmental Factors on the Estimation of Stomatal Diffusion Resistance
A physical mathematical model of water transportation in the soil-plant-atmosphere continuum have been developed recently. To predict daily actual transpiration,much more detailed studies on the behavior of stomata are needed. To make a behavior model of stomatal resistance,concurrent measurements of irradiance,leaf water potential,air temperature,leaf temperature,net radiation,CO₂ concentration, humidity, wind speed and stomatal resistance were obtained in cucumbers under wet soil conditions. The same measurements were made in soybeans under dry and wet conditions. The results indicated that light is likely to have an important role on stomatal behavior under any soil water status. The relationship between stomatal resistance and light fits a hyperbolic curve as shown in Fig. 2. But the duirnal change in leaf water potential did not measurably affect stomatal resistance
Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms
The specific aminoacylation of tRNA by tyrosyl-tRNA synthetases (TyrRSs) relies on the identity determinants in the cognate tRNATyrs. We have determined the crystal structure of Saccharomyces cerevisiae TyrRS (SceTyrRS) complexed with a Tyr-AMP analog and the native tRNATyr(GΨA). Structural information for TyrRS–tRNATyr complexes is now full-line for three kingdoms. Because the archaeal/eukaryotic TyrRSs–tRNATyrs pairs do not cross-react with their bacterial counterparts, the recognition modes of the identity determinants by the archaeal/eukaryotic TyrRSs were expected to be similar to each other but different from that by the bacterial TyrRSs. Interestingly, however, the tRNATyr recognition modes of SceTyrRS have both similarities and differences compared with those in the archaeal TyrRS: the recognition of the C1-G72 base pair by SceTyrRS is similar to that by the archaeal TyrRS, whereas the recognition of the A73 by SceTyrRS is different from that by the archaeal TyrRS but similar to that by the bacterial TyrRS. Thus, the lack of cross-reactivity between archaeal/eukaryotic and bacterial TyrRS-tRNATyr pairs most probably lies in the different sequence of the last base pair of the acceptor stem (C1-G72 vs G1-C72) of tRNATyr. On the other hand, the recognition mode of Tyr-AMP is conserved among the TyrRSs from the three kingdoms
Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis
Conditional knockout mice for Atg9a, specifically in brain tissue, were generated to understand the roles of ATG9A in the neural tissue cells. The mice were born normally, but half of them died within one wk, and none lived beyond 4 wk of age. SQSTM1/p62 and NBR1, receptor proteins for selective autophagy, together with ubiquitin, accumulated in Atg9a-deficient neurosoma at postnatal d 15 (P15), indicating an inhibition of autophagy, whereas these proteins were significantly decreased at P28, as evidenced by immunohistochemistry, electron microscopy and western blot. Conversely, degenerative changes such as spongiosis of nerve fiber tracts proceeded in axons and their terminals that were occupied with aberrant membrane structures and amorphous materials at P28, although no clear-cut degenerative change was detected in neuronal cell bodies. Different from autophagy, diffusion tensor magnetic resonance imaging and histological observations revealed Atg9a-deficiency-induced dysgenesis of the corpus callosum and anterior commissure. As for the neurite extensions of primary cultured neurons, the neurite outgrowth after 3 d culturing was significantly impaired in primary neurons from atg9a-KO mouse brains, but not in those from atg7-KO and atg16l1-KO brains. Moreover, this tendency was also confirmed in Atg9a-knockdown neurons under an atg7-KO background, indicating the role of ATG9A in the regulation of neurite outgrowth that is independent of autophagy. These results suggest that Atg9a deficiency causes progressive degeneration in the axons and their terminals, but not in neuronal cell bodies, where the degradations of SQSTM1/p62 and NBR1 were insufficiently suppressed. Moreover, the deletion of Atg9a impaired nerve fiber tract formation
Hyper-luminous Dust Obscured Galaxies discovered by the Hyper Suprime-Cam on Subaru and WISE
We present the photometric properties of a sample of infrared (IR) bright
dust obscured galaxies (DOGs). Combining wide and deep optical images obtained
with the Hyper Suprime-Cam (HSC) on the Subaru Telescope and all-sky mid-IR
(MIR) images taken with Wide-Field Infrared Survey Explorer (WISE), we
discovered 48 DOGs with and , where
, , and [22] represent AB magnitude in the -band,
-band, and 22 m, respectively, in the GAMA 14hr field
( 9 deg). Among these objects, 31 ( 65 %) show power-law
spectral energy distributions (SEDs) in the near-IR (NIR) and MIR regime, while
the remainder show a NIR bump in their SEDs. Assuming that the redshift
distribution for our DOGs sample is Gaussian, with mean and sigma = 1.99
0.45, we calculated their total IR luminosity using an empirical relation
between 22 m luminosity and total IR luminosity. The average value of the
total IR luminosity is (3.5 1.1) L, which
classifies them as hyper-luminous infrared galaxies (HyLIRGs). We also derived
the total IR luminosity function (LF) and IR luminosity density (LD) for a
flux-limited subsample of 18 DOGs with 22 m flux greater than 3.0 mJy and
with -band magnitude brighter than 24 AB magnitude. The derived space
density for this subsample is log = -6.59 0.11 [Mpc]. The
IR LF for DOGs including data obtained from the literature is well fitted by a
double-power law. The derived lower limit for the IR LD for our sample is
3.8 10 [L Mpc] and
its contributions to the total IR LD, IR LD of all ultra-luminous infrared
galaxies (ULIRGs), and that of all DOGs are 3 %, 9 %, and 15 %,
respectively.Comment: 15 pages, 15 figures, and 3 tables, accepted for publication in PASJ
(Subaru special issue
Development of the photomultiplier tube readout system for the first Large-Sized Telescope of the Cherenkov Telescope Array
The Cherenkov Telescope Array (CTA) is the next generation ground-based very
high energy gamma-ray observatory. The Large-Sized Telescope (LST) of CTA
targets 20 GeV -- 1 TeV gamma rays and has 1855 photomultiplier tubes (PMTs)
installed in the focal plane camera. With the 23 m mirror dish, the night sky
background (NSB) rate amounts to several hundreds MHz per pixel. In order to
record clean images of gamma-ray showers with minimal NSB contamination, a fast
sampling of the signal waveform is required so that the signal integration time
can be as short as the Cherenkov light flash duration (a few ns). We have
developed a readout board which samples waveforms of seven PMTs per board at a
GHz rate. Since a GHz FADC has a high power consumption, leading to large heat
dissipation, we adopted the analog memory ASIC "DRS4". The sampler has 1024
capacitors per channel and can sample the waveform at a GHz rate. Four channels
of a chip are cascaded to obtain deeper sampling depth with 4096 capacitors.
After a trigger is generated in a mezzanine on the board, the waveform stored
in the capacitor array is subsequently digitized with a low speed (33 MHz) ADC
and transferred via the FPGA-based Gigabit Ethernet to a data acquisition
system. Both a low power consumption (2.64 W per channel) and high speed
sampling with a bandwidth of 300 MHz have been achieved. In addition, in
order to increase the dynamic range of the readout we adopted a two gain system
achieving from 0.2 up to 2000 photoelectrons in total. We finalized the board
design for the first LST and proceeded to mass production. Performance of
produced boards are being checked with a series of quality control (QC) tests.
We report the readout board specifications and QC results.Comment: In Proceedings of the 34th International Cosmic Ray Conference
(ICRC2015), The Hague, The Netherlands. All CTA contributions at
arXiv:1508.0589
The Nature of Ultra-Luminous Compact X-Ray Sources in Nearby Spiral Galaxies
Studies were made of ASCA spectra of seven ultra-luminous compact X-ray
sources (ULXs) in nearby spiral galaxies; M33 X-8 (Takano et al. 1994), M81 X-6
(Fabbiano 1988b; Kohmura et al. 1994; Uno 1997), IC 342 Source 1 (Okada et al.
1998), Dwingeloo 1 X-1 (Reynolds et al. 1997), NGC 1313 Source B (Fabbiano &
Trinchieri 1987; Petre et al. 1994), and two sources in NGC 4565 (Mizuno et al.
1999). With the 0.5--10 keV luminosities in the range 10^{39-40} ergs/s, they
are thought to represent a class of enigmatic X-ray sources often found in
spiral galaxies. For some of them, the ASCA data are newly processed, or the
published spectra are reanalyzed. For others, the published results are quoted.
The ASCA spectra of all these seven sources have been described successfully
with so called multi-color disk blackbody (MCD) emission arising from
optically-thick standard accretion disks around black holes. Except the case of
M33 X-8, the spectra do not exhibit hard tails. For the source luminosities not
to exceed the Eddington limits, the black holes are inferred to have rather
high masses, up to ~100 solar masses. However, the observed innermost disk
temperatures of these objects, Tin = 1.1--1.8 keV, are too high to be
compatible with the required high black-hole masses, as long as the standard
accretion disks around Schwarzschild black holes are assumed. Similarly high
disk temperatures are also observed from two Galactic transients with
superluminal motions, GRO 1655-40 and GRS 1915+105. The issue of unusually high
disk temperature may be explained by the black hole rotation, which makes the
disk get closer to the black hole, and hence hotter.Comment: submitted to ApJ, December 199
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