SOLAR ACTIVITY AND PECULIARITIES OF THE RHEOLOGICAL PROPERTIES OF THE BLOOD IN PATIENTS WITH ANGINA PECTORIS

The peculiarities of the rheological properties of the blood are studied in patients with non-stable angina pectohs in different perbds of solar activity. It has been established, that in high solar activity hemorheological disorders are characterized by increase of blood viscosity and compensatory decrease oferythrocyte aggregation and increase of their deformation. In low solar activity less perceptible hyperviscositywas accompanied by significant increase oferythrocyte aggregation and decrease of their deformity capacity

Features of cutaneous microcirculatory blood flow in patients with pulmonary hypertension of different etiology

Aim: to evaluate features of the functional state of microvascular bed of the skin in patients with pulmonary arterial hypertension associated to congenital cardiac disease (PAH-CCD) and chronic thromboembolic pulmonary hypertension (CTEPH). Methods. In study included 25 patients (41.6±15.8) with PAH-CCD, 25 patients (48.8±14.2) with CTEPH and 25 healthy volunteers (39.3±10.1 years). All the patients underwent a six-minute walking test (6-MWT), transthoracic echocardiography, thorax organs radiography, right heart catheterization (RHC) and Laser Doppler flowmetry (LDF) with amplitude and frequency wavelet analysis of blood flow oscillations and evaluation of constrictory and dilatatoryskin resistive microvesselsfunctions. Results. In the PAH-CCD in relation to the CTEPH groupaccording to the RHC were noted significantly higher values of systolic pressure in pulmonary artery (93.2 and 77.8 mm Hg respectively) and venous mixted blood saturation(63 and 57% Hg respectively). On this background 6-MWT distance was 356 and 325 m, the Borg dyspnea scale index was on average 3.12 and 3.76 respectively. According to the LDF pulseoximetry PAH-CCD and CTEPH patients had 90.1 and 94.7% respectively. According to the LDF with amplitude and frequency wavelet analysis the PAH-CCD patients had significantly higher values of the amplitude of myogenic, respiratory and pulse sectionof blood flow modulation, and also increased constrictory activity smooth muscle cells of skin precapillary arterioles in response to the stretching at venous occlusion and decreased dilatatory reserve at post-occlusive reactive hyperemia. According to the LDF the CTEPH patients had elongationof time development of microvessel constriction in response to activation of sympathetic nervous systemin respiratory and cold tests. Conclusion. According to the LDF functional state of skin microvessels in systemic circulation of the CTEPH patients was comparable with control groupexcept for elongation of time development of microvessel reactions for sympathetic vasoconstrictor stimulations. The PAH-CCD patients demonstrated basal tonus decreasing of smooth muscle cells of skin precapillary arterioles in systemic circulation, which can be regarded as a manifestation of autoregulatory response to systemic hypoxia

Relationship between the blood levels of inflammatory cytokines and the number of circulating tumor cells with response to standard chemotherapy in patients with ovarian cancer

Introduction. Serum chemokines are inflammatory mediators, which role is shown in the occurrence and progression of a number of malignant tumors. Produced by white blood cells, stem cells, tumor and endothelial cells, chemokines control their movement and positioning. Chronic inflammation underlies the progression of ovarian cancer (OC). This increases the likelihood of chemokines stimulating or blocking tumor progression. The aim of the study was to evaluate the relationship between the blood levels of inflammatory cytokines in blood and the number of circulating tumor cells (CTCs) with the response to standard chemotherapy (CT) in patients with cancer. Material and Methods. In patients with primary OC before and after 2–4 courses of chemotherapy and in patients with benign ovarian tumors (as a control), serum levels of CCL2, CCL3, CCL4, CXCL8 and CX3CL1 were evaluated by multiplex xMAP analysis. The amount of CTCs (population CD45-/ Epcam+/CK+) was determined using a flow cytometer. Patients with ovarian cancer were divided into 3 groups according to the platinum sensitivity criterion of GCJG 4th, and progression-free interval (PFI) was determined. Results. It was found that the levels of CCL2, CCL3, CCL4, CXCL8, and CX3CL1 in case of OC did not significantly differ from that in the control, strongly negatively correlated with age (except for the CCL2 level). CT significantly increased the level of CCL2 in the group of refractory OC; of CCL3 – in the group of sensitive OC, of CCL4 – in the groups of resistant and sensitive OC, and CXCL8 level increased in the groups with resistant and sensitive OC and decreased in the group of refractory OC. The number of CTCs in patients with OC was significantly higher than in the control. After CT, a decrease in the amount of CTCs strongly and significantly correlated with a decrease in the level of CX3CL1 in the groups of refractory and sensitive OC. The maximum PFI occurred with an increase in serum levels of CCL3, CXCL8, a decrease in CCL4 and a constant level of CX3CL1. Conclusion. Thus, no significant differences in the levels of CCL2, CCL3, CCL4, and IL-8 between patients with OC and control groups were found. The levels of chemokines studied and the amount of CTCs differed in the groups divided by the tumor sensitivity to CT. We observed significant correlations between the amount of CTCs and the level of CX3CL1 in the group of platinum-sensitive OC

Magneto-optical response enhancement in 1D and 2D magnetoplasmonic crystals

10.1117/12.820704Proceedings of SPIE - The International Society for Optical Engineering7353-PSIS

Ultrafast all-optical tuning of direct-gap semiconductor metasurfaces

Optical metasurfaces are regular quasi-planar nanopatterns that can apply diverse spatial and spectral transformations to light waves. However, metasurfaces are no longer adjustable after fabrication, and a critical challenge is to realise a technique of tuning their optical properties that is both fast and efficient. We experimentally realise an ultrafast tunable metasurface consisting of subwavelength gallium arsenide nanoparticles supporting Mie-type resonances in the near infrared. Using transient reflectance spectroscopy, we demonstrate a picosecond-scale absolute reflectance modulation of up to 0.35 at the magnetic dipole resonance of the metasurfaces and a spectral shift of the resonance by 30 nm, both achieved at unprecedentedly low pump fluences of less than 400 μJ cm–2. Our findings thereby enable a versatile tool for ultrafast and efficient control of light using light

Optimization of two-photon absorption enhancement in one-dimensional photonic crystals with defect states

10.1007/s00340-005-1730-8Applied Physics B: Lasers and Optics803359-363APBO