An Efficient Learning of Constraints For Semi-Supervised Clustering using Neighbour Clustering Algorithm

Data mining is the process of finding the previously unknown and potentially interesting patterns and relation in database. Data mining is the step in the knowledge discovery in database process (KDD) .The structures that are the outcome of the data mining process must meet certain condition so that these can be considered as knowledge. These conditions are validity, understandability, utility, novelty, interestingness. Researcher identifies two fundamental goals of data mining: prediction and description. The proposed research work suggests the semi-supervised clustering problem where to know (with varying degree of certainty) that some sample pairs are (or are not) in the same class. A probabilistic model for semi-supervised clustering based on Shared Semi-supervised Neighbor clustering (SSNC) that provides a principled framework for incorporating supervision into prototype-based clustering. Semi-supervised clustering that combines the constraint-based and fitness-based approaches in a unified model. The proposed method first divides the Constraint-sensitive assignment of instances to clusters, where points are assigned to clusters so that the overall distortion of the points from the cluster centroids is minimized, while a minimum number of must-link and cannot-link constraints are violated. Experimental results across UCL Machine learning semi-supervised dataset results show that the proposed method has higher F-Measures than many existing Semi-Supervised Clustering methods

A rare case report on primary sjogren’s syndrome complicating as osteomalacia with renal tubular acidosis in a tertiary care teaching hospital tirupathi

Renal involvement in Sjogren’s syndrome (SS) is not uncommon and may precede other complaints. Tubulointerstitial nephritis is the most common renal disease in SS and may lead to, renal tubular acidosis (RTA), which in turn may cause osteomalacia. Nevertheless, osteomalacia rarely occurs as the first manifestation of a renal tubule connective tissue disorder due to SS. Here we are presenting a female patient of age 41 yrs was admitted in our hospital with chief complaints of bilateral thigh pain which restrict her walking with weakness. x-ray of long bone shows that extensive demineralization of the bone. Laboratory investigations revealed hypokalemia (3.2 mmol/L), hypophosphatemia (0.4 mmol/L), hypocalcemia (2.14 mmol/L) and hyperchloremic metabolic acidosis (chlorine: 214 mmol/L; alkaline reserve: 14 mmol/L). The serum alkaline phosphatase levels were elevated. The serum levels of 25-hydroxyvitamin D and 1,25-dihydroxy vitamin D were low and borderline low, respectively, and the parathyroid hormone level was 90 pg/L. Urinalysis showed inappropriate alkaline urine (urinary PH: 7), glycosuria. These values indicated the presence of both distal and proximal RTA. Our patient reported dryness of the mouth and eyes and Schirmer’s test showed xerophthalmia