Interactive drama in real and virtual worlds.

How do we resolve the paradox of computer-supported interactive drama - that the human participant requires the very freedom to interact that the authored narrative structure denies them? This paper reports work around the concept of Emergent Narrative - the development of narrative structure through interaction itself. We cover both systems using a virtual world and those using a virtually-augmented real world, exploring how far reworking narrative structure as a loop between the causal (plot) and affective (character) can produce engaging experiences for participants. We discuss the key role of a cognitive-affective architecture for charac-ters and the process of cognitive appraisal as an engine for both in-character and in-role dramatic action

Learning Through Multimedia Interaction: The Construal of Primary Social Science Knowledge in Web-based Digital Learning Materials

This thesis is concerned with the construal and the recontextualisation of primary social science knowledge in hypermedia texts. More specifically, it provides an account for the relations between verbiage and image in web-based multimodal interactive leaning materials, known as Multimodal Interactives (MIs). Based on the linguistic description, the thesis offers insights into the ways in which knowledge is construed and recontextaulised in the emerging electronic multimodal discourses. The general theoretical orientation of this thesis is that of systemic functional multimodal discourse analysis (SF-MDA). Within the framework of SF-MDA, the thesis proposes a complementary perspective on intersemiosis, which treats relations between verbiage and image as patterns formed during the unfolding of a text. To capture this type of intersemiotic relations, the thesis develops a logogenetic model for SF-MDA. The defining feature the model is the temporal axis (time), which serves as the main reference point for determining semiotic units (logogenetic units) and describing semiotic patterns (logogenetic patterns). The logogenetic model is applied in studying five MIs. The basic logogenetic unit used in analysis is Critical Path, the shortest traversal through a MI. Two types of logogenetic patterns along the Critical Paths in the five MIs are examined in detail, including intersemiotic ideational coupling and clustering. There are five basic types of verbiage-imaged coupling emerged from the analysis, including Naming & Identifying, Representing, Classifying & Co-classifying, and Circumstantiating. The analysis of ideational clustering shows the different ways in which participants and activities form clusters in each MI. By analysing intersemiotic coupling and clustering, the thesis shows that language and image construe the keys notions of primary social science such as people, place and community through three fundamental principles—abstraction, generalisation and specification. The study also demonstrates the possibility of achieving different degrees of pedagogic framing in hypermedia environments

Astronomical Observations

OBJECTIVE: To investigate the role of Fcg receptor (FcgR) genes in susceptibility to rheumatoid arthritis (RA) using family based studies, to examine possible interactions between FcgR genotypes and the shared epitope (SE), and to assess linkage disequilibrium between FcgR loci. METHODS: Association studies were performed in 95 Caucasian, single-case, nuclear Caucasian families with both parents alive using haplotype based haplotype relative risk (HHRR) and transmission disequilibrium test (TDT) statistics. Three FcgR polymorphisms (FcgRIIA-131H/R, FcgRIIIA-158V/F, and FcgRIIIB-NA1/NA2) were genotyped using polymerase chain reaction methods. Linkage analysis was performed using 3 microsatellite markers (D1S498, D1S2844, D1S2762) flanking the FcgR region in an independent set of 90 Caucasian, multiple-case families. Potential effects of disease heterogeneity, including sex and the presence of rheumatoid factor, SE, and erosive or nodular disease, were taken into account in the analysis. Logistic regression analysis was performed to determine whether FcgR alleles are independent risk factors for the susceptibility to and/or severity of RA. Linkage disequilibrium was calculated using pairwise linkage disequilibrium statistics. RESULTS: HHRR and TDT analysis showed no evidence of preferential transmission of any FcgR alleles studied, and there were no important associations with any given disease phenotype. Moreover, neither linkage to microsatellite markers close to the FcgR genes on chromosome 1 nor linkage disequilibrium between FcgR loci was present in our population. The distribution of inherited genotypes provided evidence for an interaction between the SE and the FcgRIIIA-158V allele and between the SE and the FcgRIIIA-158V-FcgRIIA-131H 2-locus haplotype since the combined presence of these factors increased the susceptibility to RA (OR 4.13, 95% CI 1.6-10.62 and OR 2.83, 95% CI 1.25-6.38, respectively). However, regression analysis showed that neither the 158V allele nor the 158V-131H haplotype contributed as independent factors to susceptibility or severity of RA. CONCLUSION: Isolated FcgR genes do not play a major independent role in susceptibility to RA. To a limited extent, the presence of high-binding alleles at the FcgRIIIA locus or at the FcgRIIIA-FcgRIIA haplotype might predispose to RA in SE positive individuals

Review of Program 1: Diagnostics, and Program 3: Genomics and Proteomics

Established and supported under the Australian Government’s Cooperative Research Centre Progra

Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes

__Introduction:__ This study aimed to evaluate whether profiles of several soluble mediators in synovial fluid and cartilage tissue are pathology-dependent and how their productio

Taxes, Trading or Both?: An Experimental Investigation of Abatement Investment under Alternative Emissions Regulation

Emissions taxes and emissions permit trading schemes are designed to reduce greenhouse gas (GHG) emissions by providing incentives for large emitters to invest in less emissions-intensive production technologies. Whereas taxes place a fixed price on emissions, tradable permit schemes include a secondary permit market, from which allowance prices emerge after the regulation enters into force. Under a newly imposed regulation, the delay in price information contributes to uncertainty about the future cost of compliance that liable emitters will face, thereby challenging liable entities’ ability to make optimal abatement investment decisions. Using laboratory experiments, this thesis examines the effects of a policy regime that is similar to the one implemented in Australia in 2012. The regime includes a staged transition over time from a regulation-free environment, to an emissions tax and then to emissions trading. The thesis examines the effects of such a staged transition on investment decisions, the level of emissions, permit prices and trading behavior, comparing it to standard policy regimes of only an emissions tax and only emissions permit trading. The findings suggest that a regime based on a staged transition from a tax to permit trading results in lower compliance costs and higher overall allocative efficiency compared to a regime based solely on emissions trading in a market of heterogeneous producing firms

Advancements in natural products chemistry : chemical constituents of Aplysilla pallida, Aplysilla rosea, Aplysilla var. sulphurea, Orthoscutilla maculata, and approaches to the synthesis of aplysulphurin

OBJECTIVES: Both stressors and stress vulnerability factors together with immune and hypothalamus-pituitary-adrenal (HPA) axis activity components have been considered to contribute to disease fluctuations of chronic inflammatory diseases, such as rheumatoid arthritis (RA). The aim of the present study was to investigate whether daily stressors and worrying as stress vulnerability factor as well as immune and HPA axis activity markers predict short-term disease activity and symptom fluctuations in patients with RA. METHODS: In a prospective design, daily stressors, worrying, HPA axis (cortisol) and immune system (interleukin (IL)-1beta, IL-6, IL-8, interferon (IFN)-gamma, tumour necrosis factor alpha) markers, clinical and self-reported disease activity (disease activity score in 28 joints, RA disease activity index), and physical symptoms of pain and fatigue were monitored monthly during 6 months in 80 RA patients. RESULTS: Multilevel modelling indicated that daily stressors predicted increased fatigue in the next month and that worrying predicted increased self-reported disease activity, swollen joint count and pain in the next month. In addition, specific cytokines of IL-1beta and IFN-gamma predicted increased fatigue 1 month later. Overall, relationships remained relatively unchanged after controlling for medication use, disease duration and demographic variables. No evidence was found for immune and HPA axis activity markers as mediators of the stress-disease relationship. CONCLUSIONS: Daily stressors and the stress-vulnerability factor worrying predict indicators of the short-term course of RA disease activity and fatigue and pain, while specific cytokines predict short-term fluctuations of fatigue. These stress-related variables and immune markers seem to affect different aspects of disease activity or symptom fluctuations independently in RA

Association of STAT4 with rheumatoid arthritis:A replication study in three European populations

OBJECTIVE: This study was undertaken to investigate the previously reported association of the STAT4 polymorphism rs7574865 with rheumatoid arthritis (RA) in 3 different European populations from Spain, Sweden, and The Netherlands, comprising a total of 2,072 patients and 2,474 controls. METHODS: Three different cohorts were included in the study: 923 RA patients and 1,296 healthy controls from Spain, 273 RA patients and 285 healthy controls from Sweden, and 876 RA patients and 893 healthy controls from The Netherlands. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the STAT4 single-nucleotide polymorphism rs7574865 using a TaqMan 5'-allele discrimination assay. The chi-square test was performed to compare allele and genotype distributions. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. RESULTS: We observed a significantly increased frequency of the minor T allele in RA patients compared with healthy controls in the Spanish population (24.8% versus 20.8%; P = 0.001, OR 1.26 [95% CI 1.09-1.45]). This association was confirmed in both the Swedish population (P = 0.03, OR 1.35 [95% CI 1.03-1.77]) and the Dutch population (P = 0.03, OR 1.45 [95% CI 1.21-1.73]). The overall P value for all 3 populations was 9.79 x 10(-6) (OR 1.25 [95% CI 1.13-1.37]). No association between rs7574865 and the presence of rheumatoid factor or anti-cyclic citrullinated peptide autoantibodies was observed. A meta-analysis of all published STAT4 associations revealed an OR of 1.25 (95% CI 1.19-1.33) (P = 1 x 10(-5)). CONCLUSION: Our findings indicate an association between the STAT4 polymorphism rs7574865 and RA in 3 different populations, from Spain, Sweden, and The Netherlands, thereby confirming previous data

KinOath Kinship Archiver Version 1.4

This talk will introduce a new tool for Humanities research, in particular Ethnology, Linguistics, Law, History, but also Genetics and Archiving. This tool is KinOath Kinship Archiver which is an application for collecting and analysing kinship data. It is designed to be flexible and culturally nonspecific, which is important to prevent extraneous concepts being imposed onto the data being recorded. The kinship data can be linked to external resources such as archive data. Graphical representation of the data is a key feature, it produces publishable quality diagrams that can be exported to SVG, PDF and JPG formats. Data can be imported from GEDCOM, CSV and TIP files. Data can be exported into CSV format, with additional formats becoming available as plugins. KinOath provides very flexible data fields for each individual / entity recorded in the kinship data, this is combined with customisable relation types, customisable symbols and customisable kin types. This means, for example, that any number of genders and kinship relations can be defined and represented on a diagram. The most common format, GEDCOM (Family History Department, 1999), can be imported into KinOath. However this GEDCOM format exhibits cultural specificities because it has a predetermined set of kinship types, genders and initiation ceremonies. We know that there is a wider array of kinship types (e.g. suckling relations (Altorki, 1980)) and genders (e.g. the Māhū of Hawaiʻi (Matzner, 2001)). There are also initiation ceremonies beyond the Christian and Jewish ceremonies that are predefined in GEDCOM. However once this data is imported, all the flexibility of KinOath will be available. KinOath has project based diagrams and freeform diagrams. Freeform diagrams are like a quick sketch; while project diagrams each have a database of kinship data which can be shared across multiple diagrams. Project based diagrams also allow kin type string queries, such that individuals to be found based on their relations to others. Individuals in a project diagram can be duplicated and merged, which can be useful, for example, in correcting data, or merging multiple data sets where some individuals overlap. In freeform diagrams kin terms can be defined with kin type strings and shown on the diagram, organised in groups, imported and exported. In the future it will be possible to overlay these kin terms onto project diagrams. In order to perform statistical analysis, the kinship data for each project or freeform diagram can be exported for use in R or SPSS. This combined with queries based on kin types and other search parameters, provides great potential in the analysis of both the kin data and the archive data that has been recorded. The intended users of Kinoath are any researchers that collect data in a context of social relations. Kinship data is often not systematically included in the metadata of archives, however these kin relations provide a context that enriches that archived data. KinOath is in active development and new features are regularly being added. The plugin framework that KinOath shares with Arbil has made it possible for external developers to add features. The various versions and the manual are available at: http://tla.mpi.nl/tools/tlatools/kinoath/ REFERENCES Family History Department of The Church of Jesus Christ of Latterday Saints, 1999, THE GEDCOM STANDARD DRAFT Release 5.5.1 http://www.phpgedview.net/ged551¬5.pdf Matzner, Andrew. 2001. 'O au no keia: voices from Hawaii's Mahu and transgender communities. Bloomington, Indiana: Xlibris. Altorki, Soraya. 1980. MilkKinship in Arab Society: An Unexplored Problem in the Ethnography of Marriage. Ethnology 19(2): 233-24