Ultrasonically Assisted Preparation of Polysaccharide Microcontainers for Hydrophobic Drugs

Stable polysaccharide microcontainers are fabricated by ultrasonically assisted procedure. Ultrasound induces formation of permanent microcontainer shell due to interaction between chitosan and xanthan gum. The obtained system has a core-shell structure with high loading capacity for hydrophobic molecules. The permanent polymer shell thickness of 7-10 nm allows to maintain the microcontainer stability for more than 4 months. The microcontainers in a wide size range of 350-7500 nm were obtained by changing an overall emulsion viscosity. Uptake of the microcontainers by mouse melanoma M3 cells was studied by flow cytometry and confocal microcscopy. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3546