THE STATES AND DEREGULATION: THE CASE OF SURFACE MINING

The Surface Mining Control and Reclamation Act of 1977 (SMCRA), passed to correct the abuses of surface mining, assigned key implementation roles to the states. While the federal government originally enforced SMCRA, states could operate the program themselves. Once states decided to run their own program the federal government would oversee them to insure they properly enforce the Act. This research examines the enforcement behavior of states in the 1980s. The results indicate that early in the Reagan administration eastern states enforced the SMCRA less stringently than other states. Eastern states increased their level of enforcement later in the 1980s in response to pressures for increased federal oversight from Congress, interest groups and others. Copyright 1989 by The Policy Studies Organization.

Developing credible vulnerability indicators for climate adaptation policy assessment

We address the issue of how to develop credible indicators of vulnerability to climate change that can be used to guide the development of adaptation policies. We compare the indicators and measures that five past national-level studies have used and examine how and why their approaches have differed. Other relevant indicator studies of social facets of society as well as vulnerability studies at sub-national level are also examined for lessons regarding best practice. We find that the five studies generally emphasise descriptive measures by aggregating environmental and social conditions. However, they vary greatly both in the types of indicators and measures used and differ substantially in their identification of the most vulnerable countries. Further analysis of scientific approaches underlying indicator selection suggests that the policy relevance of national-level indicators can be enhanced by capturing the processes that shape vulnerability rather than trying to aggregate the state itself. Such a focus can guide the selection of indicators that are representative even when vulnerability varies over time or space. We find that conceptualisation regarding how specific factors and processes influencing vulnerability interact is neither given sufficient consideration nor are assumptions transparently defined in previous studies. Verification has been neglected, yet this process is important both to assess the credibility of any set of measures and to improve our understanding of vulnerability. A fundamental lesson that emerges is the need to enhance our understanding of the causes of vulnerability in order to develop indicators that can effectively aid policy development

Resequencing study confirms that host defense and cell senescence gene variants contribute to the risk of idiopathic pulmonary fibrosis

Rationale: Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. Objectives: To develop an integrated understanding of the rare and common variants located in multiple loci that have been reported to contribute to the risk of disease. Methods: We performed deep targeted resequencing (3.69 Mb of DNA) in cases (n = 3,624) and control subjects (n = 4,442) across genes and regions previously associated with disease. We tested for associations between disease and 1) individual common variants via logistic regression and 2) groups of rare variants via sequence kernel association tests. Measurements and Main Results: Statistically significant common variant association signals occurred in all 10 of the regions chosen based on genome-wide association studies. The strongest risk variant is the MUC5B promoter variant rs35705950, with an odds ratio of 5.45 (95% confidence interval, 4.91–6.06) for one copy of the risk allele and 18.68 (95% confidence interval, 13.34–26.17) for two copies of the risk allele (P = 9.60 × 10−295). In addition to identifying for the first time that rare variation in FAM13A is associated with disease, we confirmed the role of rare variation in the TERT and RTEL1 gene regions in the risk of IPF, and found that the FAM13A and TERT regions have independent common and rare variant signals. Conclusions: A limited number of common and rare variants contribute to the risk of idiopathic pulmonary fibrosis in each of the resequencing regions, and these genetic variants focus on biological mechanisms of host defense and cell senescence