Relationship between cortisol and physical performance in older persons

Objective: Hypercortisolism is associated with muscle weakness. This study examines the relationship between cortisol and physical performance in older persons. Design/patients: The study was conducted within the Longitudinal Aging Study Amsterdam (LASA), an ongoing cohort study in a population-based sample of healthy older persons in the Netherlands. Data from the second (1995/1996) and fourth (2001/2002) cycle were used pertaining to 1172 (65-88 years) and 884 (65-94 years) men and women, respectively. Measurements: Physical performance was measured by adding up scores on the chair stands, tandem stand and walk test (range 0-12). In the second cycle serum total and calculated free cortisol were assessed; in the fourth cycle evening salivary cortisol was assessed. Regression analysis (stratified for sex, adjusted for age, body mass index, alcohol use, physical activity and region) was performed to examine the cross-sectional relationship between cortisol and physical performance. Results: Women with higher calculated free cortisol scored less well on physical performance (b = -0.28 per SD higher cortisol, P = 0.016), which was mainly explained by poorer performance on the tandem stand (OR = 1.32 for a lower score per SD higher cortisol, P = 0.003). Men with higher salivary cortisol scored less well on physical performance (b = -0.90 in the highest vs. the lowest quartile, P = 0.008), which was mainly explained by poorer performance on the chair stands and walk test (OR = 1.88, P = 0.020 and OR = 1.81, P = 0.027, respectively, in the highest vs. the lowest quartile). Conclusion: Physical performance is negatively associated with high cortisol levels in older persons. © 2007 The Authors

A cognitive framework for the categorisation of auditory objects in urban soundscapes

Categorisation is a fundamental cognitive process that plays a central role in everyday behaviour and action. Whereas previous studies have investigated the categorisation of isolated everyday sounds, this paper presents an experiment to investigate the cognitive categorisation of everyday sounds within their original context. A group of eighteen expert and non-expert listeners took part in a free sorting task using 110 sounds identified within ambisonic reproductions of urban soundscapes. The participants were asked to sort the objects into groups of sounds that served a similar purpose in the overall perception of the soundscape. Following this, the participants were asked to provide descriptive labels for the groups they had formed. The results were analysed using hierarchical agglomerative clustering and non-metric multidimensional scaling (MDS) to explore both the structure and dimensionality of the data. The resulting hierarchical clustering of objects show three top level categories relating to transient sounds, continuous sounds, and speech and vocalisations. Sub-categories were identified in each of the top level categories which included harmonic and non-harmonic continuous sounds, clear speech, unintelligible speech, vocalisations, transient sounds that indicate actions, and non-salient transient sounds. The first two dimensions revealed by the MDS analysis relate to temporal extent and intelligibility respectively. Interpretation of the third dimension is less clear, but may be related to harmonic content