39 research outputs found
Cavity-enhanced direct frequency comb spectroscopy
Cavity-enhanced direct frequency comb spectroscopy combines broad spectral
bandwidth, high spectral resolution, precise frequency calibration, and
ultrahigh detection sensitivity, all in one experimental platform based on an
optical frequency comb interacting with a high-finesse optical cavity. Precise
control of the optical frequency comb allows highly efficient, coherent
coupling of individual comb components with corresponding resonant modes of the
high-finesse cavity. The long cavity lifetime dramatically enhances the
effective interaction between the light field and intracavity matter,
increasing the sensitivity for measurement of optical losses by a factor that
is on the order of the cavity finesse. The use of low-dispersion mirrors
permits almost the entire spectral bandwidth of the frequency comb to be
employed for detection, covering a range of ~10% of the actual optical
frequency. The light transmitted from the cavity is spectrally resolved to
provide a multitude of detection channels with spectral resolutions ranging
from a several gigahertz to hundreds of kilohertz. In this review we will
discuss the principle of cavity-enhanced direct frequency comb spectroscopy and
the various implementations of such systems. In particular, we discuss several
types of UV, optical, and IR frequency comb sources and optical cavity designs
that can be used for specific spectroscopic applications. We present several
cavity-comb coupling methods to take advantage of the broad spectral bandwidth
and narrow spectral components of a frequency comb. Finally, we present a
series of experimental measurements on trace gas detections, human breath
analysis, and characterization of cold molecular beams.Comment: 36 pages, 27 figure
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Renal cell carcinoma(RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival
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The statistical properties of electromagnetic fields with application to radiation and scattering
Determining the relationships between different average values is an important step in any physics-based statistical theory. If these relationships exist and exhibit certain properties, then probability densities or distributions can be assigned to the field variables and the transition from an average-value theory'' to a statistical theory'' is complete. For electromagnetics, no such average-value relationships have been demonstrated to exist. The derivation of these relationships and their range of validity are the subject of consideration here. For purposes of this discussion, we limit our attention to the fields inside a complex cavity, but with the ultimate goal of deriving the statistics of the far radiated and scattered fields of complex envelopes