Атопический дерматит: оптимизация топической терапии

Goal. Determination of the skin microbiocenosis in patients with atopic dermatitis (AtD) and evaluation of the treatment efficacy for AtD patients using isoconazole nitrate and diflucortolone valerate. Materials and methods. The authors assessed skin microflora in 168 AtD patients. Skin scrapes were obtained for further microscopy, and inoculation tests were performed. As many as 59 secondary AtD patients were treated with a combination of isoconazole nitrate and diflucortolone valerate as well as methylprednisolone aceponate, drugs from the DARDIA line. The treatment efficacy was evaluated clinically based on the SCORAD index as well as skin microrelief assessed with the use of the Visioscan BW30 video camera. After the treatment with Travocort, the nature and degree of skin colonization with AtD microorganisms were also assessed. Results. The efficacy of topical administration of isoconazole nitrate and diflucortolone valerate as well as methylprednisolone aceponate, drugs from the DARDIA line, was confirmed for the treatment of secondary AtD patients. Conclusion. Making antibiotics and antimycotic agents a part of the complex therapy of secondary AtD patients seems to be expedient for eliminating pathogenic microorganisms.Цель. Определение микробиоценоза кожи у больных атопическим дерматитом (АтД) и оценка эффективности терапии больных АтД с использованием препарата изоконазола нитрата и дифлукортолона валерата. Материал и методы. Проведена оценка микрофлоры кожи 168 больных АтД. Получали соскобы кожи, которые изучали микроскопически, а также проводили посев на питательные среды. 59 больным АтД, осложненным вторичным инфицированием, была проведена терапия с применением комбинированного препарата изоконазола нитрата и дифлукортолона валерата, а также метилпреднизолона ацепоната, препаратов линии DARDIA. Эффективность лечения оценивали клинически с помощью индекса SCORAD, а также по состоянию микрорельефа кожи, оценивавшегося с помощью видеокамеры Visioscan BW30. Кроме того, после лечения препаратом Травокорт повторно оценивали характер и степень колонизации кожи больных АтД микроорганизмами. Результаты. Показана эффективность топического применения изоконазола нитрата и дифлукортолона валерата, метилпреднизолона ацепоната, препаратов линии DARDIA в лечении больных АтД, осложненным вторичным инфицированием. Заключение. При АтД, осложненном вторичным инфицированием, в целях элиминации патогенных микроорганизмов представляется оправданным включение в комплексную терапию пациентов антибиотиков и антимикотиков

EFFICACY OF PATHOGENETIC THERAPY FOR ATOPIC DERMATITIS IN INFANTS

The article looks at the issue of atopic dermatitis as a manifestation of atopic march in infants. Authors provide results of their own observations in the use of modern topical steroid — mometasone furoate — in the integrated therapy. This glucocorticosteroid does not contain fluorine and has predominantly non-genomic mechanism. The results of the study evidenced a high efficacy and good tolerance to this topical steroid. Key words: atopic dermatitis, children, momethasone furoate. (Pediatric Pharmacology. – 2010; 7(2):87-90

EFFICACY OF PATHOGENETIC THERAPY FOR ATOPIC DERMATITIS IN INFANTS

The article looks at the issue of atopic dermatitis as a manifestation of atopic march in infants. Authors provide results of their own observations in the use of modern topical steroid — mometasone furoate — in the integrated therapy. This glucocorticosteroid does not contain fluorine and has predominantly non-genomic mechanism. The results of the study evidenced a high efficacy and good tolerance to this topical steroid. Key words: atopic dermatitis, children, momethasone furoate. (Pediatric Pharmacology. – 2010; 7(2):87-90

APPLICATION EFFICIENCY OF THE MODERN FORMULA BASED ON THE GOAT'S MILK IN FEEDING OF THE INFANTS, SUFFERING FROM ATOPIC DERMATITIS

The purpose of the works consisted in the study of the diet therapy efficiency along with the use of the modern adapted formula based on the goat's milk "Nanny" in feeding of the infants, who are bottle fed and who suffer from atopic dermatitis. The researchers have observed 58 children aged between 3 and 12 months old with atopic dermatitis complicated by the mycotic infection. The main group was made up of 32 children, who received the formula based on the goat's milk within the hypoallergic diet. The control group was made up of 26 children, who received a formula based on the soy protein isolates. Introduction of the formula based on the goat's milk into the food ration of the infants with atopic dermatitis provided the high clinical efficiency in 78% of cases. It manifested itself in achievement of the disease remission by the 10–20th day from the moment the therapy started, reduction of scorad index by 3,5 times, reduction of the atopic dermatitis recrudescence period by 2 times, protraction of the remission by 3 times, reduction of the backsets by 2,5 times against concentration reduction of IgE and allergen specific IgE to the cow milk proteins and casein in blood serum as far as it concerns the adequate growth and development of a child. Thus, the replacement of the products based on the cow milk for the wholesome children formula based on the goat's milk in the food ration of the patients, suffering from atopic dermatitis, allowed for both optimizing the diet therapy of the infants, ensuring their adequate physical growth and contributing to the control over the symptoms of disease.Key words: goats milk formula, atopic dermatitis, infants, treatment

APPLICATION EXPERIENCE OF GOAT'S MILK BASED PRODUCTS AMONG CHILDREN, SUFFERING FROM ATOPIC DERMATITIS

The purpose of the work is to study the efficiency of the diet therapy against atopic dermatitis by means of the goat's milk based products among children at different age. The researchers observed 188 children aged between 3 months and 18 years, suffering from atopic dermatitis aggravated by the mycotic infection. Patients of the main group (102 children under 3) received goat's milk based products within the hypo allergic diet — «Nanny» and «Nanny — Zolotaya Kozochka» adapted milk formulas, while children over 3 received «Amal Tea» instant goat's milk. The research findings have showed that the introduction of the goat's milk based products into the food ration leads not only to the positive short term results — achievement of the clinical remission on 12th–20th day from the moment the therapy starts, but also to the positive long term effect — remission extension, reduction of the disease recurrences, reduction of the general IgE level in blood serum and offending IgE allergens to the cow milk proteins and casein. Thus, the replacement of the cow milk based products within the ration of patients for «Nanny» and «Nanny — Zolotaya Kozochka» adapted milk formulas and «Amal Tea» instant goat's milk allows for optimization of the atopic dermatitis diet therapy among children at different age.Key words: atopic dermatitis, diet therapy, goat's milk.</strong

EXPERIENCE OF GOAT'S MILK «АMALTEA» APPLICATION IN CHILDREN WITH ATOPIC DERMATITIS

For the purpose of this work, the authors studied the efficiency of the dutch instant goat's milk «Amaltea» among preschool and school children with aggravated forms of atopic dermatitis and mycotic infection. Under surveillance, there were 66 children aged between 3 and 18 years old with atopic dermatitis aggravated by the fungal infection. 36 of them received the dutch wholesome goat's milk «Amaltea» within the hypoallergenic diet. The test group was composed of 30 children, getting the milk free diet. The use of the dutch instant goat's milk «Amaltea» within the ration of the infants with atopic dermatitis aggravated by the fungal infection leads both to the short cterm positive results — clinical remission on the 12–20th day from the beginning of the therapy and to the long cterm positive effects — prolongation of the remission period by 3 times, reduction of the recurrences by 2.8 times against the decrease of the general IgE contents within the blood serum and allergenic specific IgE antibodies towards the proteins of the cow milk and casein. Thus, the replacement of the cow milk based products for the wholesome goat's milk «Amaltea» within the ration of the patients allows optimizing the diet therapy among preschool and school children, suffering from atopic dermatitis.Key words: children, atopic dermatitis, diet therapy, goat's milk

APPLICATION EXPERIENCE OF GOAT'S MILK BASED PRODUCTS AMONG CHILDREN, SUFFERING FROM ATOPIC DERMATITIS

The purpose of the work is to study the efficiency of the diet therapy against atopic dermatitis by means of the goat's milk based products among children at different age. The researchers observed 188 children aged between 3 months and 18 years, suffering from atopic dermatitis aggravated by the mycotic infection. Patients of the main group (102 children under 3) received goat's milk based products within the hypo allergic diet — «Nanny» and «Nanny — Zolotaya Kozochka» adapted milk formulas, while children over 3 received «Amal Tea» instant goat's milk. The research findings have showed that the introduction of the goat's milk based products into the food ration leads not only to the positive short term results — achievement of the clinical remission on 12th–20th day from the moment the therapy starts, but also to the positive long term effect — remission extension, reduction of the disease recurrences, reduction of the general IgE level in blood serum and offending IgE allergens to the cow milk proteins and casein. Thus, the replacement of the cow milk based products within the ration of patients for «Nanny» and «Nanny — Zolotaya Kozochka» adapted milk formulas and «Amal Tea» instant goat's milk allows for optimization of the atopic dermatitis diet therapy among children at different age.Key words: atopic dermatitis, diet therapy, goat's milk

PECULIARITIES OF TREATMENT OF RECURRENT BRONCHITIS IN FREQUENTLY AILING CHILDREN WITH FUNGAL AND BACTERIAL COLONIZATION OF NASOPHARYNX

90 frequently ailing children (FAC) under the age 3–7 years old with recurrent bronchitis were observed. In 53 (59%) of them a colonization of mucous tunica with Candida and Staphylococcus aureus was revealed. The complex treatment of bronchitis in 33 children included fusafungine (Bioparox), having high activity against S. aureus and Candida (4 nasal and 4 oral inhalations 4 times daily during 7–10 days). The control group contained 20 children, receiving traditional treatment. It was shown that complex treatment with fusafungine is effective in 79% of cases. The duration of exacerbation was decreased 1,8 times lower and the remission was prolonged two times longer on the basis of negative results of cultural mycological and bacteriological tests. Described complex treatment with fusafungine can be widely used in FAC with recurrent bronchitis, associated Candida and S. aureus.Key words: frequently ailing children, recurrent bronchitis, Сandida, Staphylococcus aureus, fusafungine.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(6):97-100)</span

ЭФФЕКТИВНОСТЬ ПАТОГЕНЕТИЧЕСКОЙ ТЕРАПИИ АТОПИЧЕСКОГО ДЕРМАТИТА У ДЕТЕЙ ПЕРВОГО ГОДА ЖИЗНИ

The article looks at the issue of atopic dermatitis as a manifestation of atopic march in infants. Authors provide results of their own observations in the use of modern topical steroid — mometasone furoate — in the integrated therapy. This glucocorticosteroid does not contain fluorine and has predominantly non-genomic mechanism. The results of the study evidenced a high efficacy and good tolerance to this topical steroid. Key words: atopic dermatitis, children, momethasone furoate. (Pediatric Pharmacology. – 2010; 7(2):87-90)В статье рассмотрена проблема атопического дерматита как проявления атопического марша у детей первого года жизни. Авторами приведены результаты собственных наблюдений по применению в комплексной терапии современного топического стероида – мометазона фуроата. Данный глюкокортикостероид не содержит фтора и имеет преимущественно внегеномный механизм действия. Результаты исследования подтвердили высокую эффективность и хорошую переносимость этого топического стероида. Ключевые слова: атопический дерматит, дети, мометазона фуроат. (Педиатрическая фармакология. – 2010; 7(2):87-90

ОСОБЕННОСТИ ДИЕТОТЕРАПИИ ПРИ ТЯЖЕЛЫХ ФОРМАХ АТОПИЧЕСКОГО ДЕРМАТИТА У ДЕТЕЙ ГРУДНОГО ВОЗРАСТА, НАХОДЯЩИХСЯ НА ИСКУССТВЕННОМ ВСКАРМЛИВАНИИ

The purpose of research was to study the efficiency of the highly hydrolyzed adapted formula in artificially fed infants with severe atopic dermatitis. The researchers examined 30 artificially fed children aged from 1 month to 1 year with severe atopic dermatitis. In 56,6% of cases, they noticed an associated skin and gastrointestinal tract allergy. Application of the highly hydrolyzed adapted compound as a part of the complex antiallergic therapy led to a long&gt;term clinical effect in 93,3% of cases. This was achieved by the remission of severe atopic dermatitis and associated gastrointestinal allergy on the 16th day on average from the treatment commencement against the decreased serum levels of general Ige and specific Ige to the к cow's milk proteins and casein. In each case the adequate growth and physical development of infants is ensured.Key words: atopic dermatitis, children, highly hydrolyzed adapted formula.Цель исследования заключалась в изучении эффективности высокогидролизированной адаптированной смеси у детей грудного возраста, находящихся на искусственном вскармливании с тяжелыми формами атопического дерматита. Обследовано 30 детей в возрасте от 1 мес до 1 года с тяжелыми формами атопического дерматита, находящихся на искусственном вскармливании. В 56,6% случаев отмечено сочетанное аллергическое поражение кожи и желудочно-кишечного тракта. Применение высокогидролизированной адаптированной смеси в составе комплексной противоаллергической терапии приводило к положительному клиническому эффекту в 93,3% случаев. Это проявилось достижением ремиссии тяжелой формы атопического дерматита и сопутствующей гастроинтестинальной аллергии в среднем на 16-й день от начала лечения на фоне снижения уровня общего IgE и специфических IgE к белкам коровьего молока и казеину. При этом обеспечивается адекватный рост и физическое развитие детей на первом году жизни. Ключевые слова: атопический дерматит, дети, высокогидролизированная адаптированная смесь.(Педиатрическая фармакология. – 2008;5(6):79-82