Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain–gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials

Asphalt emulsion radon barrier systems for uranium mill tailings: an overview of the technology

Pacific Northwest Laboratory (PNL), under contract to the US Department of Energy (DOE) Uranium Mill Tailings Remedial Action Project (UMTRAP) office, has developed an asphalt emulsion cover system to reduce the release of radon from uranium mill tailings. The system has been field tested at Grand Junction, Colorado. Results from laboratory and field tests indicate that this system is effective in reducing radon release to near-background levels (<2.5 pCi m/sup -2/s/sup -1/) and has the properties required for long-term effectiveness and stability. Engineering specifications have been developed, and analysis indicates that asphalt emulsion covers are cost-competitive with other cover systems. This report summarizes the technology for asphalt emulsion radon barrier systems. 59 references, 45 figures, 36 tables

Towards Automatic Detection and Tracking of Topic Change

Abstract. We present an approach for automatic detection of topic change. Our approach is based on the analysis of statistical features of topics in time-sliced corpora and their dynamics over time. Processing large amounts of time-annotated news text, we identify new facets regarding a stream of topics consisting of latest news of public interest. Adaptable as an addition to the well known task of topic detection and tracking we aim to boil down a daily news stream to its novelty. For that we examine the contextual shift of the concepts over time slices. To quantify the amount of change, we adopt the volatility measure from econometrics and propose a new algorithm for frequency-independent detection of topic drift and change of meaning. The proposed measure does not rely on plain word frequency but the mixture of the co-occurrences of words. So, the analysis is highly independent of the absolute word frequencies and works over the whole frequency spectrum, especially also well for low-frequent words. Aggregating the computed time-related data of the terms allows to build overview illustrations of the most evolving terms for a whole time span.