Barriers to access and ways to improve dementia services for a minority ethnic group in England

Rationale, aims and objectives: Much emphasis has been placed on the lack of awareness and understanding of dementia that exist within the ethnic minority groups in the UK. There has been a continual dearth of research, however, among the ethnic minority carers about reducing barriers to accessing services and optimising engagements with religiously tailored interventions. This paper reports findings from a qualitative study that examined the barriers to healthcare service use in Bangladeshi ethnic minority population. Method: This analysis piece draws on findings from a doctoral level research study of understanding dementia among the Bangladeshi community in England. The doctoral research which informed this paper was gathered in two distinct phases: 1) focus group discussions and 2) semi-structured qualitative interviews. All data were audio-recorded and analysed using thematic analysis. The NVivo qualitative software was utilised to simplify the thematic analysis, including transcribing, coding, and interpreting the emergent themes. Results: Some barriers arose out of their religious and cultural beliefs and practices, other barriers related to the complexity of the healthcare system. Gender based caregiving interferes with their religious ideologies while religiously appropriate services are of precise importance when investigating access to services. Conclusion: The findings provide understanding into the development of seeking healthcare services within the mainstream services and it may serve to give a useful direction to future enquiry

Sistim gotong royong dalam masyarakat pedesaan Propinsi Daerah Istimewa Aceh

Sistem gotong-royong merupakan suatu hal yang bertambah penting, apalagi kalau diingat bahwa generasi muda Indonesia nanti akan mengetahui bagaimana mereka dari generasi yang lalu mengembangkan dan membina nilai-nilai luhur yang terpancar dari unsur budaya mereka. Buku ini memuat berbagai informasi yang tumbuh dan berkembang dalam masyarakat tempo dulu mengenai sistim gotong royong dalam masyarakat pedesaan Propinsi Daerah Istimewa Aceh

Synthesis and structural features of copper(II) complexes of N,N,N′,N′-tetramethylethylenediamine with 2-chlorobenzoate1− and 2-hydroxybenzoate1−

Published online 22 Jan 2019.Peer reviewedPostprin

SEBARAN, POTENSI DAN KUALITAS KAYU EBONI (Diospyros celebica Bakh.) DI SULAWESI

Ebony (Diospyros celebica Bakh.) isan endemic species of Sulawesi. The heartwood of ebony is composed of a series of axial and alternating black and paler streaks. Thisstreak pattern determinesof wood quality. Excessive exploitation causes ebony become scarce and has been classified as vulnerable by IUCN and Appendix II by UNEP - WCMC. Currentdistribution, potency (standing stock) and wood quality of each natural habitat of ebony in Sulawesi are not yet known. This study aims to determine the distribution, potency and wood quality on its natural habitat in Sulawesi. Standing stock data obtained with inventory and the results of the previous inventory.  GPS coordinates of each habitat is taken to make a map. Streaks quality class based on ebony factory standard in Palu and Makassar. The results showed that habitat of ebony was naturally found in Districts of Gowa, Maros, Pangkep, Barru, Sidenreng Rappang, Luwu, Luwu Timur (South Sulawesi Province), Mamuju (West Sulawesi Province), Donggala, Parigi Moutong, Poso and Morowali (Central Sulawesi Province).  The highest standing stock was found at Cenrana, Maros which is about 95,05 m3ha-1.  Most of the remaining ebony habitat were found in the protected areas. Wood quality class A and B were found in Sausu and Poso while other areas classified as class C. Key Words:  Ebony Wood,  Endemic Species Of Sulawesi, Strike Quality

A Rewriting-Logic-Based Technique for Modeling Thermal Systems

This paper presents a rewriting-logic-based modeling and analysis technique for physical systems, with focus on thermal systems. The contributions of this paper can be summarized as follows: (i) providing a framework for modeling and executing physical systems, where both the physical components and their physical interactions are treated as first-class citizens; (ii) showing how heat transfer problems in thermal systems can be modeled in Real-Time Maude; (iii) giving the implementation in Real-Time Maude of a basic numerical technique for executing continuous behaviors in object-oriented hybrid systems; and (iv) illustrating these techniques with a set of incremental case studies using realistic physical parameters, with examples of simulation and model checking analyses.Comment: In Proceedings RTRTS 2010, arXiv:1009.398

Exploring the determinants of global life expectancy in an ecological perspective

Objective: This study is designed to understand the impacts of demographic events, socioeconomic differentials, health factors’ availability, and environmental reasons which influence life expectancy (LE) globally. Methods: Data of 183 countries were taken from the United Nations agencies. The predicted variable was LE, and the determinants were demographic events, socioeconomic factors, health-related factors, and environmental issues. Descriptive statistics, correlation analysis, and backward multiple regression analysis were used to reach the research objectives. Results: The lowest LEs are found in the African countries; and LE is found significantly associated (p<0.05) with a wide range of demographic, socioeconomic, health, and environmental factors. The necessity of full coverage of immunization, higher income, and improved sanitation are more expected to raise LE. However, LE may be increased by way of decrease fertility, Human Immunodeficiency Virus (HIV) prevalence, and carbon dioxide (CO2) emissions. Conclusions: The LE is influenced by different demographic, socioeconomic, health, and environmental factors. Country-level and global efforts should be taken to raise LE throughout the reduction of HIV infection, births, and CO2 emissions. The policy-makers should focus on the advancing reproductive decisions, increasing immunization coverage, and upturning improved sanitation usage

Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for faithful assignment of amino acids to their cognate tRNA. Variants in ARS genes are frequently associated with clinically heterogeneous phenotypes in humans and follow both autosomal dominant or recessive inheritance patterns in many instances. Variants in tryptophanyl-tRNA synthetase 1 (WARS1) cause autosomal dominantly inherited distal hereditary motor neuropathy and Charcot-Marie-Tooth disease. Presently, only one family with biallelic WARS1 variants has been described. We present three affected individuals from two families with biallelic variants (p.Met1? and p.(Asp419Asn)) in WARS1, showing varying severities of developmental delay and intellectual disability. Hearing impairment and microcephaly, as well as abnormalities of the brain, skeletal system, movement/gait, and behavior were variable features. Phenotyping of knocked down wars-1 in a C. elegans model showed depletion is associated with defects in germ cell development. A wars1 knockout vertebrate model recapitulates the human clinical phenotypes, confirms variant pathogenicity and uncovers evidence implicating the p.Met1? variant as potentially impacting an exon critical for normal hearing. Together, our findings provide consolidating evidence for biallelic disruption of WARS1 as causal for an autosomal recessive neurodevelopmental syndrome and present a vertebrate model that recapitulates key phenotypes observed in patients. This article is protected by copyright. All rights reserved

Refined histopathological predictors of BRCA1 and BRCA2 mutation status: A large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

Introduction: The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Methods: Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Measurement of the azimuthal anisotropy of Y(1S) and Y(2S) mesons in PbPb collisions at √S^{S}NN = 5.02 TeV

The second-order Fourier coefficients (υ$_{2}$) characterizing the azimuthal distributions of Υ(1S) and Υ(2S) mesons produced in PbPb collisions at $\sqrt{s_{NN}}$ = 5.02 TeV are studied. The Υmesons are reconstructed in their dimuon decay channel, as measured by the CMS detector. The collected data set corresponds to an integrated luminosity of 1.7 nb$^{-1}$. The scalar product method is used to extract the υ$_{2}$ coefficients of the azimuthal distributions. Results are reported for the rapidity range |y| < 2.4, in the transverse momentum interval 0 < p$_{T}$ < 50 GeV/c, and in three centrality ranges of 10–30%, 30–50% and 50–90%. In contrast to the J/ψ mesons, the measured υ$_{2}$ values for the Υ mesons are found to be consistent with zero