1 research outputs found
ΠΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π² ΠΎΡΡΡΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ°
Objective: to study the specific features of metabolism and blood rheological properties in the acute period of ischemic stroke (IS) in patients aged less than 50 years.Subjects and methods. Thirty patients (mean age 45.1Β±1.1 years) having acute IS were examined. According to its severity, the patients were divided into 3 groups: 1) 8 patients with mild IS; 2) 11 patients with moderate IS; 3) 11 with severe IS. All Group 3 patients were treated at an intensive care unit. A control group comprised 20 healthy individuals (mean age 44.7Β±1.0 years). In all the patients, fasting blood homocysteine concentrations were measured on an IMMULITE One immunochemiluminescent analyzer (USA). The rheological properties of blood were examined, by measuring its viscosity on a rotary viscometer (Russia) at a shear rate of 10 to 200 sec-1. Fibrinogen concentrations were determined on an ACL-100 coagulograph.Results. The patients who had experienced ischemic stroke at the age of under 50 years were found to have atherogenic dyslipidemia, elevated homocysteine and fibrinogen levels and considerably increased blood viscosity, which correlated with the severity of their condition and the outcome of stroke. The highest values were noted in patients with severe ischemic stroke and a poor outcome.Conclusion. Studies of homocysteine and fibrinogen concentrations and blood viscosity may be used as additional criteria for evaluating the severity of ischemic stroke and predicting its outcome in patients aged less than 50 years.Β Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΠ·ΡΡΠΈΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° ΠΈ ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΊΡΠΎΠ²ΠΈ Π² ΠΎΡΡΡΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΠΈΡΠ΅ΠΌΠΈΡΠ΅-ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ° (ΠΠ) Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ Π΄ΠΎ 50 Π»Π΅Ρ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 30 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² ΠΎΡΡΡΠΎΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΠΠ (ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ 45,1Β±1,1 Π»Π΅Ρ). ΠΠΎ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ»ΠΈ Π½Π° ΡΡΠΈ Π³ΡΡΠΏΠΏΡ: 1-Ρ Π³ΡΡΠΏΠΏΠ° β ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ Ρ ΠΠ Π»Π΅Π³ΠΊΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ (n=8), 2-Ρ β ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ Ρ ΠΠ ΡΡΠ΅Π΄Π½Π΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ (n=11), 3-Ρ β ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ Ρ ΠΠ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ (n=11). ΠΡΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ ΡΡΠ΅ΡΡΠ΅ΠΉ Π³ΡΡΠΏΠΏΡ Π½Π°Ρ
ΠΎΠ΄ΠΈΠ»ΠΈΡΡ Π½Π° Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΈΠΈ. ΠΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 20 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΠΈΡ (ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ 44,7Β±1,0 Π»Π΅Ρ). Π£ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π°ΡΠΎΡΠ°ΠΊ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π² ΠΊΡΠΎΠ²ΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π° Π½Π° ΠΈΠΌΠΌΡΠ½ΠΎΡ
Π΅ΠΌΠΈΠ»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠ½ΠΎΠΌ Π°Π½Π°Π»ΠΈΠ·Π°ΡΠΎΡΠ΅ Β«IMMULITE OneΒ» (Π‘Π¨Π). ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° (ΠΎΠ±ΡΠΈΠΉ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½, Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½ Π»ΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ΄ΠΎΠ² ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ, ΡΡΠΈΠ³Π»ΠΈ-ΡΠ΅ΡΠΈΠ΄Ρ) ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π°Π²ΡΠΎΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ Π½Π° Π°Π½Π°Π»ΠΈΠ·Π°ΡΠΎΡΠ΅ Β«HITACHI-912Β». Π Π΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΊΡΠΎΠ²ΠΈ ΠΈΠ·ΡΡΠ°Π»ΠΈ, ΠΈΠ·ΠΌΠ΅ΡΡΡ Π΅Π΅ Π²ΡΠ·ΠΊΠΎΡΡΡ Π½Π° ΡΠΎΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ Π²ΠΈΡΠΊΠΎΠ·ΠΈΠΌΠ΅ΡΡΠ΅ (Π ΠΎΡΡΠΈΡ) ΠΏΡΠΈ ΡΠΊΠΎΡΠΎΡΡΡΡ
ΡΠ΄Π²ΠΈΠ³Π° Π² Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ ΠΎΡ 10 Π΄ΠΎ 200Ρ-1. ΠΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ³Π΅Π½Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π½Π° ΠΊΠΎΠ°Π³ΡΠ»ΠΎΠ³ΡΠ°ΡΠ΅ ACL-100.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΡ
ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈΠ½ΡΡΠ»ΡΡ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ Π΄ΠΎ 50 Π»Π΅Ρ, ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ Π°ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΠΉ Π΄ΠΈΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΊΠΎΡΡΠ΅Π»ΠΈΡΡΡΡΠΈΠ΅ ΡΠΎ ΡΡΠ΅ΠΏΠ΅Π½ΡΡ ΡΡΠΆΠ΅ΡΡΡΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΈ ΠΈΡΡ
ΠΎΠ΄ΠΎΠΌ ΠΈΠ½ΡΡΠ»ΡΡΠ° ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π°, ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ³Π΅Π½Π° ΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ Π²ΡΠ·ΠΊΠΎΡΡΠΈ ΠΊΡΠΎΠ²ΠΈ. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΎΡΠΌΠ΅ΡΠ΅Π½Ρ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΈΠ½ΡΡΠ»ΡΡΠΎΠΌ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ, Ρ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΠΌ ΠΈΡΡ
ΠΎΠ΄ΠΎΠΌ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π³ΠΎΠΌΠΎΡΠΈΡΡΠ΅ΠΈΠ½Π°, ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ³Π΅Π½Π° ΠΈ Π²ΡΠ·ΠΊΠΎΡΡΠΈ ΠΊΡΠΎΠ²ΠΈ ΠΌΠΎΠ³ΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² ΠΏΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΡ
ΠΎΠ΄Π° ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠ° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ Π΄ΠΎ 50 Π»Π΅Ρ.