Structure of the Isovector Dipole Resonance in Neutron-Rich 60Ca^{60}Ca Nucleus and Direct Decay from Pygmy Resonance

The structure of the isovector dipole resonance in neutron-rich calcium isotope, $^{60}Ca$, has been investigated by implementing a careful treatment of the differences of neutron and proton radii in the continuum random phase approximation ($RPA$). The calculations have taken into account the current estimates of the neutron skin. The estimates of the escape widths for direct neutron decay from the pygmy dipole resonance ($PDR$) were shown rather wide, implicating a strong coupling to the continuum. The width of the giant dipole resonance ($GDR$) was evaluated, bringing on a detailed discussion about its microscopic structure.Comment: 13 pages, 2 figures, RevTex

Pml represses tumour progression through inhibition of mTOR

The promyelocytic leukaemia gene PML is a pleiotropic tumour suppressor. We have recently demonstrated that PML opposes mTOR-HIF1α-VEGF signalling in hypoxia. To determine the relevance of PML-mTOR antagonism in tumourigenesis, we have intercrossed Pml null mice with Tsc2 heterozygous mice, which develop kidney cysts and carcinomas exhibiting mTOR upregulation. We find that combined inactivation of Pml and Tsc2 results in aberrant TORC1 activity both in pre-tumoural kidneys as well as in kidney lesions. Such increase correlates with a marked acceleration in tumour progression, impacting on both the biology and histology of kidney carcinomas. Also, Pml inactivation decreases the rate of loss of heterozygosity (LOH) for the wt Tsc2 allele. Interestingly, however, aberrant TORC1 activity does not accelerate renal cystogenesis in Tsc2/Pml mutants. Our data demonstrate that activation of mTOR is critical for tumour progression, but not for tumour initiation in the kidney

Effect of eutrophication on the distribution of arsenic species in eutrophic and mesotrophic lakes

金沢大学理工研究域物質化学系Effects of eutrophication on arsenic speciation were studied in eutrophic Lake Kiba and mesotrophic Lake Biwa, Japan. By combining hydride generation atomic absorption spectrometry with ultraviolet irradiation, inorganic, methyl and ultraviolet-labile fractions of arsenic were determined. In both Lakes, inorganic species (As(V + III)) dominated over other forms of arsenic all the year round. Most of methylarsenic fraction was dimethylarsinic acid (DMAA), and the concentration of monomethylarsonic acid (MMAA) was below the detection limit. Measurements of size-fractioned arsenic concentrations in water column indicate that most of the DMAA was distributed in truly dissolved fraction ( 0.45 μm) and colloidal (10 kDa-0.45 μm) fractions. Arsenic speciation in eutrophic Lake Kiba fluctuated greatly with season. The ultraviolet-labile fractions were observed with the increase of DMAA from May to October, and they disappeared with the decrease of DMAA in January. In mesotrophic Lake Biwa, the ultraviolet-labile fractions of arsenic were not influenced as much as those in eutrophic Lake Kiba. On the other hand DMAA concentration was higher in Lake Biwa compared to that in Lake Kiba. The results suggest that the biosynthesis of complex organoarsenicals was enhanced by eutrophication, and the arsenic speciation would be influenced by the balance of biological processes in natural waters. © 2008 Elsevier B.V. All rights reserved