Bordetella pertussis Infection or Vaccination Substantially Protects Mice against B. bronchiseptica Infection

Although B. bronchiseptica efficiently infects a wide range of mammalian hosts and efficiently spreads among them, it is rarely observed in humans. In contrast to the many other hosts of B. bronchiseptica, humans are host to the apparently specialized pathogen B. pertussis, the great majority having immunity due to vaccination, infection or both. Here we explore whether immunity to B. pertussis protects against B. bronchiseptica infection. In a murine model, either infection or vaccination with B. pertussis induced antibodies that recognized antigens of B. bronchiseptica and protected the lower respiratory tract of mice against three phylogenetically disparate strains of B. bronchiseptica that efficiently infect naïve animals. Furthermore, vaccination with purified B. pertussis-derived pertactin, filamentous hemagglutinin or the human acellular vaccine, Adacel, conferred similar protection against B. bronchiseptica challenge. These data indicate that individual immunity to B. pertussis affects B. bronchiseptica infection, and suggest that the high levels of herd immunity against B. pertussis in humans could explain the lack of observed B. bronchiseptica transmission. This could also explain the apparent association of B. bronchiseptica infections with an immunocompromised state

A note on the measurement of bias in stated willingness to pay for public goods

No abstract available

Retrait par voie endoveineuse de sondes infectees de stimulateurs cardiaques. A propos de cinq cas. [Intravenous withdrawal of infected cardiac pacemaker electrodes. Apropos of 5 cases]

Infection of a cardiac pacemaker and its electrodes is one of the most serious complications after implantation of a pacemaker, as it can be life-threatening and constitutes an absolute indication for complete withdrawal of the implanted material which, up until recently, could only be performed by thoracotomy or sternotomy with or without cardiopulmonary bypass. A new transvenous technique for complete removal of the infected pacemaker system has been recently described. We report 5 cases of infected pacemaker systems in which this technique was used successfully allowing withdrawal of 10 electrodes and thereby avoiding the need for a major surgical operation