Ambrose Burnside, the Ninth Army Corps, and the Battle of Spotsylvania Court House

The fighting on May 12, 1864 at Spotsylvania Court House evokes thoughts of the furious combat at the Bloody Angle. However, there is another aspect of the fighting on May 12, that is, incidentally, at another salient. The then-independent command of Ambrose Burnside’s Ninth Corps spent the day fighting on the east flank of the Mule Shoe, and charging against the Confederate right flank at Heth’s Salient. This paper has two parts: the first half analyzes the complexities and problems of Burnside’s return to the Eastern Theater since his disastrous defeat at Fredericksburg in 1862, starting in April 1864 and culminating with the opening moves of the Overland Campaign. In the second half the paper examines the fighting on May 12—tactically how and why Burnside was repulsed, while strategically it examines the larger repercussions of the fighting on May 12, including the pivotal position of Heth’s Salient in defending Lee’s flank and reserve line. I would like to acknowledge the staff and volunteers at the Fredericksburg and Spotsylvania National Military Park for their help with this paper. Especial thanks are due to Peter Maugle, Eric Mink and Rebecca Capobianco for their assistance in a last-minute request locating Henry Heth’s official report

Universality of Leading Relativistic Corrections to Bound State Gyromagnetic Ratios

We discuss the leading relativistic (nonrecoil and recoil) corrections to bound state $g$-factors of particles with arbitrary spin. These corrections are universal for any spin and depend only on the free particle gyromagnetic ratios. We explain the physical reasons behind this universality.Comment: 10 pp., based on talks given at the Gribov-80 Memorial Workshop, ICTP, Trieste, Italy, May 2010 and at PSAS 2010 workshop, Les Houches, June 2010. To be published in the Gribov-80 Proceedings and in Can. J. Phy

SAMplus: adaptive optics at optical wavelengths for SOAR

Adaptive Optics (AO) is an innovative technique that substantially improves the optical performance of ground-based telescopes. The SOAR Adaptive Module (SAM) is a laser-assisted AO instrument, designed to compensate ground-layer atmospheric turbulence in near-IR and visible wavelengths over a large Field of View. Here we detail our proposal to upgrade SAM, dubbed SAMplus, that is focused on enhancing its performance in visible wavelengths and increasing the instrument reliability. As an illustration, for a seeing of 0.62 arcsec at 500 nm and a typical turbulence profile, current SAM improves the PSF FWHM to 0.40 arcsec, and with the upgrade we expect to deliver images with a FWHM of $\approx0.34$ arcsec -- up to 0.23 arcsec FWHM PSF under good seeing conditions. Such capabilities will be fully integrated with the latest SAM instruments, putting SOAR in an unique position as observatory facility.Comment: To appear in Proc. SPIE 10703 (Ground-based and Airborne Instrumentation for Astronomy VII; SPIEastro18

Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein

BACKGROUND: Alzheimer’s disease (AD) and other tauopathies are neurodegenerative disorders characterized by cellular accumulation of aggregated tau protein. Tau pathology within these disorders is accompanied by chronic neuroinflammation, such as activation of the classical complement pathway by complement initiation factor C1q. Additionally, about half of the AD cases present with inclusions composed of aggregated alpha-synuclein called Lewy bodies. Lewy bodies in disorders such as Parkinson’s disease and Lewy body dementia also frequently occur together with tau pathology. OBJECTIVE: Immunotherapy is currently the most promising treatment strategy for tauopathies. However, the presence of multiple pathological processes within tauopathies makes it desirable to simultaneously target more than one disease pathway. METHODS: Herein, we have developed three bispecific antibodies based on published antibody binding region sequences. One bispecific antibody binds to tau plus alpha-synuclein and two bispecific antibodies bind to tau plus C1q. RESULTS: Affinity of the bispecific antibodies to their targets compared to their monospecific counterparts ranged from nearly identical to one order of magnitude lower. All bispecific antibodies retained binding to aggregated protein in patient-derived brain sections. The bispecific antibodies also retained their ability to inhibit aggregation of recombinant tau, regardless of whether the tau binding sites were in IgG or scFv format. Mono- and bispecific antibodies inhibited cellular seeding induced by AD-derived pathological tau with similar efficacy. Finally, both Tau-C1q bispecific antibodies completely inhibited the classical complement pathway. CONCLUSIONS: Bispecific antibodies that bind to multiple pathological targets may therefore present a promising approach to treat tauopathies and other neurodegenerative disorders

Aspen: A microsimulation model of the economy

This report presents, Aspen. Sandia National Laboratories is developing this new agent-based microeconomic simulation model of the U.S. economy. The model is notable because it allows a large number of individual economic agents to be modeled at a high level of detail and with a great degree of freedom. Some features of Aspen are (a) a sophisticated message-passing system that allows individual pairs of agents to communicate, (b) the use of genetic algorithms to simulate the learning of certain agents, and (c) a detailed financial sector that includes a banking system and a bond market. Results from runs of the model are also presented

Aspen: A microsimulation model of the economy

This report presents, Aspen. Sandia National Laboratories is developing this new agent-based microeconomic simulation model of the U.S. economy. The model is notable because it allows a large number of individual economic agents to be modeled at a high level of detail and with a great degree of freedom. Some features of Aspen are (a) a sophisticated message-passing system that allows individual pairs of agents to communicate, (b) the use of genetic algorithms to simulate the learning of certain agents, and (c) a detailed financial sector that includes a banking system and a bond market. Results from runs of the model are also presented

A compilation, tabulation and analysis of spelling errors made by pupils in grades four, five, and six in free writing of sentences using given stimuli words

Thesis (M.A.)--Boston Universit