34 research outputs found

    New insights on COPD imaging via CT and MRI

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    Multidetector-row computed tomography (MDCT) can be used to quantify morphological features and investigate structure/function relationship in COPD. This approach allows a phenotypical definition of COPD patients, and might improve our understanding of disease pathogenesis and suggest new therapeutical options. In recent years, magnetic resonance imaging (MRI) has also become potentially suitable for the assessment of ventilation, perfusion and respiratory mechanics. This review focuses on the established clinical applications of CT, and novel CT and MRI techniques, which may prove valuable in evaluating the structural and functional damage in COPD

    An Observational Study to Develop a Predictive Model for Bacterial Pneumonia Diagnosis in Severe COVID-19 Patients—C19-PNEUMOSCORE

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    In COVID-19 patients, antibiotics overuse is still an issue. A predictive scoring model for the diagnosis of bacterial pneumonia at intensive care unit (ICU) admission would be a useful stewardship tool. We performed a multicenter observational study including 331 COVID-19 patients requiring invasive mechanical ventilation at ICU admission; 179 patients with bacterial pneumonia; and 152 displaying negative lower-respiratory samplings. A multivariable logistic regression model was built to identify predictors of pulmonary co-infections, and a composite risk score was developed using & beta;-coefficients. We identified seven variables as predictors of bacterial pneumonia: vaccination status (OR 7.01; 95% CI, 1.73-28.39); chronic kidney disease (OR 3.16; 95% CI, 1.15-8.71); pre-ICU hospital length of stay & GE; 5 days (OR 1.94; 95% CI, 1.11-3.4); neutrophils & GE; 9.41 x 10(9)/L (OR 1.96; 95% CI, 1.16-3.30); procalcitonin & GE; 0.2 ng/mL (OR 5.09; 95% CI, 2.93-8.84); C-reactive protein & GE; 107.6 mg/L (OR 1.99; 95% CI, 1.15-3.46); and Brixia chest X-ray score & GE; 9 (OR 2.03; 95% CI, 1.19-3.45). A predictive score (C19-PNEUMOSCORE), ranging from 0 to 9, was obtained by assigning one point to each variable, except from procalcitonin and vaccine status, which gained two points each. At a cut-off of & GE;3, the model exhibited a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 84.9%, 55.9%, 69.4%, 75.9%, and 71.6%, respectively. C19-PNEUMOSCORE may be an easy-to-use bedside composite tool for the early identification of severe COVID-19 patients with pulmonary bacterial co-infection at ICU admission. Its implementation may help clinicians to optimize antibiotics administration in this setting

    Accuracy of computed tomography and magnetic resonance imaging in staging bronchogenic carcinoma

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    Sixty-three patients with non-small cell bronchogenic carcinoma were prospectively and independently assessed by computed tomography (CT) and magnetic resonance imaging (MRI) before surgery. Images were interpreted by four radiologists who had no knowledge of other imaging studies, except chest x-ray, and were blinded to surgical findings. The data were compared with pathologic and histologic findings. The accuracies of CT and MRI in determining tumor classification and assessing mediastinal and hilar lymph node metastases were compared. Sensitivity of CT in determining T factor was 78%, and specificity was 96%. The values for MRI were 84% and 96%, respectively. There was no significant difference between CT and MRI in staging tumors. MRI is more accurate than CT in diagnosing mediastinal invasion in staging superior sulcus tumors and complex tumors. There was no significant difference between the accuracies of CT and MRI in detecting mediastinal node metastases; the sensitivities were 82% and 90%, respectively, and specificities were 88% and 93%, respectively

    Diagnostic imaging and therapy in a case of myasthenia gravis associated with thymic hyperplasia

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    none5.noneFOSCHI R; RINALDI P; MEDURI A; CAMPIONI P; PIRRONTI TFoschi, R; Rinaldi, P; Meduri, A; Campioni, Paolo; Pirronti, T

    Xeroradiografia e Radiografia Digitale a Luminescenza nello Studio delle Tecniche di Manifattura della Ceramica Antica: Vantaggi e Limiti

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    Applicazione sperimentale di indagini radiografiche a ceramiche preistoriche per definire la portata e la sensibilit\ue0 di diverse applicazion
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