7 research outputs found
Ruthenium Catalyzed Reductive Coupling of Paraformaldehyde to Trifluoromethyl Allenes: CF<sub>3</sub>‑Bearing All-Carbon Quaternary Centers
Trifluoromethyl substituted allenes engage in ruthenium catalyzed reductive couplings with paraformaldehyde to form products of hydrohydroxymethylation as single regioisomers. This method enables generation of CF<sub>3</sub>-bearing all-carbon quaternary stereocenters
Synthesis and Evaluation of Sterically Demanding Ruthenium Dithiolate Catalysts for Stereoretentive Olefin Metathesis
Dithiolate ligands
have recently been used in ruthenium-catalyzed
olefin metathesis and have provided access to a kinetically <i>E</i> selective pathway through stereoretentive olefin metathesis.
The typical dithiolate used is relatively simple with low steric demands
imparted on the catalyst. We have developed a synthetic route that
allows access to sterically demanding dithiolate ligands. The catalysts
generated provided a pathway to study the intricate structure–activity
relationships in olefin metathesis. It was found that DFT calculations
can predict the ligand arrangement around the ruthenium center with
remarkable accuracy. These dithiolate catalysts proved resistant to
ligand isomerization and were stable even under forcing conditions.
Additionally, catalyst initiation and olefin metathesis studies delivered
a better understanding to the interplay between dithiolate ligand
structure and catalyst activity and selectivity
Enantioselective Conversion of Primary Alcohols to α-<i>exo</i>-Methylene γ-Butyrolactones via Iridium-Catalyzed C–C Bond-Forming Transfer Hydrogenation: 2-(Alkoxycarbonyl)allylation
Upon exposure of acrylic ester <b>1</b> to alcohols <b>2a</b>–<b>i</b> in the presence of a cyclometalated
iridium catalyst modified by (−)-TMBTP, catalytic C–C
coupling occurs, providing enantiomerically enriched 5-substituted
α-<i>exo</i>-methylene γ-butyrolactones <b>3a</b>–<b>i</b>. Bromination of the methylene butyrolactone
products followed by zinc-mediated reductive aldehyde addition provides
the disubstituted α-<i>exo</i>-methylene γ-butyrolactones <b>6a</b> and <b>6b</b> with good to excellent levels of diastereoselectivity
Ruthenium Catalyzed Hydrohydroxyalkylation of Isoprene with Heteroaromatic Secondary Alcohols: Isolation and Reversible Formation of the Putative Metallacycle Intermediate
Heteroaromatic secondary alcohols
react with isoprene to form products
of hydrohydroxyalkylation in the presence of ruthenium(0) catalysts
generated from Ru<sub>3</sub>(CO)<sub>12</sub> and tricyclohexylphosphine,
enabling direct conversion of secondary to tertiary alcohols in the
absence of premetalated reagents or stoichiometric byproducts. The
putative oxaruthenacycle intermediate has been isolated and characterized,
and reversible metallacycle formation has been demonstrated
Ruthenium Catalyzed Hydrohydroxyalkylation of Isoprene with Heteroaromatic Secondary Alcohols: Isolation and Reversible Formation of the Putative Metallacycle Intermediate
Heteroaromatic secondary alcohols
react with isoprene to form products
of hydrohydroxyalkylation in the presence of ruthenium(0) catalysts
generated from Ru<sub>3</sub>(CO)<sub>12</sub> and tricyclohexylphosphine,
enabling direct conversion of secondary to tertiary alcohols in the
absence of premetalated reagents or stoichiometric byproducts. The
putative oxaruthenacycle intermediate has been isolated and characterized,
and reversible metallacycle formation has been demonstrated
Benzannulation via Ruthenium-Catalyzed Diol–Diene [4+2] Cycloaddition: One- and Two-Directional Syntheses of Fluoranthenes and Acenes
A new benzannulation protocol is
described and applied to the synthesis
of polycyclic aromatic hydrocarbons. Ruthenium(0)-catalyzed diol–diene
[4+2] cycloaddition delivers cyclohex-1-ene-4,5-diols, which are subject
to aromatization upon dehydration or Nicholas diol deoxydehydration.
Employing diol and tetraol reactants, benzannulation can be conducted
efficiently in one- and two-directional modes, respectively, as illustrated
in the construction of substituted fluoranthenes and acenes
Ruthenium-Catalyzed C–C Coupling of Amino Alcohols with Dienes via Transfer Hydrogenation: Redox-Triggered Imine Addition and Related Hydroaminoalkylations
Ruthenium-catalyzed hydrogen transfer
from 4-aminobutanol to butadiene
results in the pairwise generation of 3,4-dihydro-2<i>H</i>-pyrrole and an allylruthenium complex, which combine to form products
of imine <i>anti</i>-crotylation. In couplings of 1-substituted-1,3-dienes,
novel C2 regioselectivity is observed. As corroborated by deuterium
labeling studies, kinetically preferred hydrometalation of the terminal
olefin of the 1-substituted-1,3-diene delivers a 1,1-disubstituted
Ï€-allylruthenium complex that isomerizes to a thermodynamically
more stable monosubstituted π-allylruthenium complex, which
undergoes imine addition with allylic inversion through a closed transition
structure. Direct ruthenium-catalyzed diene hydroaminoalkylations
with pyrrolidine also are described