Malignant melanoma of the conjunctiva: a case report with examination of KIT and PDGFRA

Although many clinicopathological studies of malignant melanoma of the conjunctiva have been reported, there have been no studies of the expression and gene mutations of KIT and PDGFRA in melanoma of the conjunctiva. A 69-year-old Japanese woman consulted our hospital because of black mass (0.7 × 0.7 × 0.6 cm) in the conjunctiva. A biopsy was taken. The biopsy showed malignant epithelioid cells with melanin deposition. Immunohistochemically, the tumor was positive for S100 protein, HMB45, p53, Ki-67 (labeling=30%), KIT and PDGFRA. The tumor was negative for pancytokeratins (AE1/3 and CAM5.2). A genetic analysis using PCR-direct sequencing revealed no mutations of KIT gene (exons 9, 11, 13, and 17) and PDGFRA gene (exons 12 and 18). The pathological diagnosis was conjunctival melanoma. Despite chemotherapy, the patient developed multiple metastases of melanoma, and died of melanoma 7 years after the biopsy. In conclusion, the author reported a case of melanoma of conjunctive expressing KIT and PDGFRA proteins without gene mutations of KIT and PDGFRA

CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung

CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung is very rare. An 82-year-old Japanese woman was found to have an abnormal lung shadow on chest X-ray photography, and was admitted to our hospital. Imaging modalities including X-ray photography, computed tomography, and magnetic resonance imaging showed a small (2 × 1 × 1 cm) opacity of the right upper lobe. Transbronchial lung biopsy was performed. It showed severe proliferation of small lymphocytes. The small lymphocytes were centrocytes-like, and minor plasma cell differentiation was recognized. Lymphoepithelial lesions were scattered. Immunohistochemically, the tumor cells were positive for CD5, CD20, CD43, CD45, CD79α, bcl-2, and κ-chain, but negative for CD2, CD3, CD10, CD21, CD23, CD35, CD45RO, CD56, IgA, IgG, IgM, IgD, λ-chain, TdT, and cyclin D1. The Ki-67 labeling was 10%. CD3-positive and CD45RO-positive inflammatory T-cells were scattered in small amount. The pathological diagnosis was CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung. The patient was treated with chemotherapy (CHOP: cyclophosphamide, hydroxydaunorbicin, vincristine, and predonisone), and the lung tumor disappeared. The patient is now free of the lymphoma 10 years after the first manifestation

Numerical and experimental verification of a theoretical model of ripple formation in ice growth under supercooled water film flow

Little is known about morphological instability of a solidification front during the crystal growth of a thin film of flowing supercooled liquid with a free surface: for example, the ring-like ripples on the surface of icicles. The length scale of the ripples is nearly 1 cm. Two theoretical models for the ripple formation mechanism have been proposed. However, these models lead to quite different results because of differences in the boundary conditions at the solid-liquid interface and liquid-air surface. The validity of the assumption used in the two models is numerically investigated and some of the theoretical predictions are compared with experiments.Comment: 30 pages, 9 figure

Angular distributions of scattered excited muonic hydrogen atoms

Differential cross sections of the Coulomb deexcitation in the collisions of excited muonic hydrogen with the hydrogen atom have been studied for the first time. In the framework of the fully quantum-mechanical close-coupling approach both the differential cross sections for the $nl \to n'l'$ transitions and $l$-averaged differential cross sections have been calculated for exotic atom in the initial states with the principle quantum number $n=2 - 6$ at relative motion energies $E_{\rm {cm}}=0.01 - 15$ eV and at scattering angles $\theta_{\rm {cm}}=0 - 180^{\circ}$. The vacuum polarization shifts of the $ns$-states are taken into account. The calculated in the same approach differential cross sections of the elastic and Stark scattering are also presented. The main features of the calculated differential cross sections are discussed and a strong anisotropy of cross sections for the Coulomb deexcitation is predicted.Comment: 5 pages, 9 figure

Deep Near-Infrared Imaging af an Embedded Cluster in the Extreme Outer Galaxy: Census of Supernovae Triggered Star Formation

While conducting a near-infrared (NIR) survey of ``Digel Clouds'', which are thought to be located in the extreme outer Galaxy (EOG), Kobayashi & Tokunaga found star formation activity in ``Cloud 2'', a giant molecular cloud at the Galactic radius of ~ 20 kpc. Additional infrared imaging showed two embedded young clusters at the densest regions of the molecular cloud. Because the molecular cloud is located in the vicinity of a supernova remnant (SNR) HI shell, GSH 138-01-94, it was suggested that the star formation activity in Cloud 2 was triggered by this expanding HI shell. We obtained deep J (1.25 um), H (1.65 um) and K (2.2 um) images of one of the embedded clusters in Cloud 2 with high spatial resolution (FWHM ~0".3) and high sensitivity (K ~ 20 mag, 10 sigma). We identified 52 cluster members. The estimated stellar density (~ 10 pc^{-2}) suggests that the cluster is a T-association. This is the deepest NIR imaging of an embedded cluster in the EOG. The observed K-band luminosity function (KLF) suggests that the underlying initial mass function (IMF) of the cluster down to the detection limit of ~ 0.1 M_sun is not significantly different from the typical IMFs in the field and in the near-by star clusters. The overall characteristics of this cluster appears to be similar to those of other embedded clusters in the far outer Galaxy. The estimated age of the cluster from the KLF, which is less than 1 Myr, is consistent with the view that the star formation was triggered by the HI shell whose age was estimated at 4.3 Myr (Stil & Irwin). The 3-dimensional geometry of SNR shell, molecular cloud and the embedded cluster, which is inferred from our data, as well as the cluster age strongly suggest that the star formation in Cloud 2 was triggered by the SNR shell.Comment: 19pages, 8 figures, 1 table, accepted to ApJ. Full paper (pdf) with high resolution figures available at http://www.ioa.s.u-tokyo.ac.jp/~ck_yasui/papers/Cloud2N_1.pd

Magnetic Fluctuations and Turbulence in the Venus Magnetosheath and Wake

Recent research has shown that distinct physical regions in the Venusian induced magnetosphere are recognizable from the variations of strength and of wave/fluctuation activity of the magnetic field. In this paper the statistical properties of magnetic fluctuations are investigated in the Venusian magnetosheath, terminator, and wake regions. The latter two regions were not visited by previous missions. We found 1/f fluctuations in the magnetosheath, large-scale structures near the terminator and more developed turbulence further downstream in the wake. Location independent short-tailed non-Gaussian statistics was observed.Comment: 16 pages, 4 figure

Peculiar outburst of A 0535+26 observed with INTEGRAL, RXTE and Suzaku

A normal outburst of the Be/X-ray binary system A0535+26 has taken place in August 2009. It is the fourth in a series of normal outbursts that have occured around the periastron passage of the source, but is unusual by starting at an earlier orbital phase and by presenting a peculiar double-peaked light curve. A first "flare" (lasting about 9 days from MJD 55043 on) reached a flux of 440 mCrab. The flux then decreased to less than 220 mCrab, and increased again reaching 440 mCrab around the periastron at MJD 55057. Target of Opportunity observations have been performed with INTEGRAL, RXTE and Suzaku. First results of these observations are presented, with special emphasis on the cyclotron lines present in the X-ray spectrum of the source, as well as in the pulse period and energy dependent pulse profiles of the source.Comment: 6 pages, Accepted for publication on PoS, Proceedings of "The Extreme sky: Sampling the Universe above 10 keV", held in Otranto (Italy) in October 200

Star Formation in the Extreme Outer Galaxy: Digel Cloud 2 Clusters

As a first step for studying star formation in the extreme outer Galaxy (EOG), we obtained deep near-infrared images of two embedded clusters at the northern and southern CO peaks of Cloud 2, which is one of the most distant star forming regions in the outer Galaxy (galactic radius R_g ~ 19 kpc). With high spatial resolution (FWHM ~ 0".35) and deep imaging (K ~ 21 mag) with the IRCS imager at the Subaru telescope, we detected cluster members with a mass detection limit of < 0.1 M_{sun}, which is well into the substellar regime. These high quality data enables a comparison of EOG to those in the solar neighborhood on the same basis for the first time. Before interpreting the photometric result, we have first constructed the NIR color-color diagram (dwarf star track, classical T Tauri star (CTTS) locus, reddening law) in the Mauna Kea Observatory filter system and also for the low metallicity environment since the metallicity in EOG is much lower than those in the solar neighborhood. The estimated stellar density suggests that an ``isolated type'' star formation is ongoing in Cloud 2-N, while a ``cluster type'' star formation is ongoing in Cloud 2-S. Despite the difference of the star formation mode, other characteristics of the two clusters are found to be almost identical: (1) K-band luminosity function (KLF) of the two clusters are quite similar, as is the estimated IMF and ages (~ 0.5--1 Myr) from the KLF fitting, (2) the estimated star formation efficiencies (SFEs) for both clusters are typical compared to those of embedded clusters in the solar neighborhood (~ 10 %). The similarity of two independent clusters with a large separation (~ 25 pc) strongly suggest that their star formation activities were triggered by the same mechanism, probably the supernova remnant (GSH 138-01-94).Comment: 14pages, 11 figures; Accepted for publication in Ap

Fuchs versus Painlev\'e

We briefly recall the Fuchs-Painlev\'e elliptic representation of Painlev\'e VI. We then show that the polynomiality of the expressions of the correlation functions (and form factors) in terms of the complete elliptic integral of the first and second kind, $K$ and $E$, is a straight consequence of the fact that the differential operators corresponding to the entries of Toeplitz-like determinants, are equivalent to the second order operator $L_E$ which has $E$ as solution (or, for off-diagonal correlations to the direct sum of $L_E$ and $d/dt$). We show that this can be generalized, mutatis mutandis, to the anisotropic Ising model. The singled-out second order linear differential operator $L_E$ being replaced by an isomonodromic system of two third-order linear partial differential operators associated with $\Pi_1$, the Jacobi's form of the complete elliptic integral of the third kind (or equivalently two second order linear partial differential operators associated with Appell functions, where one of these operators can be seen as a deformation of $L_E$). We finally explore the generalizations, to the anisotropic Ising models, of the links we made, in two previous papers, between Painlev\'e non-linear ODE's, Fuchsian linear ODE's and elliptic curves. In particular the elliptic representation of Painlev\'e VI has to be generalized to an ``Appellian'' representation of Garnier systems.Comment: Dedicated to the : Special issue on Symmetries and Integrability of Difference Equations, SIDE VII meeting held in Melbourne during July 200