MAIN MEASURES TO PREVENT «ATYPICAL PNEUMONIA» IMPORTATION AND DISSEMINATION AT IRKUTSKAYA PROVINCE TERRITORY

Organizing, preventive and anti-epidemic measures performed at the territory of Irkutskaya Province at the period of acute severe respiratory syndrome outbreak in the world are analyzed. The current experience  will be used for improvement of the epidemiological surveillance to polish tactics of the preventive and anti-epidemic measures in case of a suspected «atypical pneumonia» patient detection

Complications of BCG vaccination: modification of the statistical procedure

There is no uniform method to conduct the epidemiological monitoring of BCG complications in the Russian Federation, Current indicators of BCG complications include the number of complication cases (cases registered within two years after vaccination) and the total number of the vaccinated children. Our aim is to discover a new indicator of BCG complications and to compare it with the indicators of the existing methods, The comparative analysis of new and existing methods of all complication cases (continuous sampling, n = 110) was conducted in the Irkutsk Region (Eastern Siberia) from 2005 to 2014, The calculating formula included the ratio of the number of children with complications vaccinated in the analyzed year to 100,000 children vaccinated in the same year, The new method shows the advantages over the existing methodological approaches, It demonstrates more adequate assessment, expressed in the highest approximation coefficient of trend model compared to the other methods, and stability of indicator over the years, The incidence of complications in the Irkutsk Region has a steady decreasing linear trend and a significant negative growth rate of the indicator (-17,9 %), The new method offers an adequate assessment and can be used as an epidemiological control system not only in the Russian Federation but in other high TB-burden countries with massive BCG vaccination of children

Synthesis, Fungicidal Activity and Plant Protective Properties of 1,2,3-Thiadiazole and Isothiazole-Based N-acyl-N-arylalaninates

The addition of active groups of known fungicides, or systemic acquired resistance inducers, into novel compound molecules to search for potential antifungal compounds is a popular and effective strategy. In this work, a new series of N-acyl-N-arylalanines was developed and synthesized, in which 1,2,3-thiadiazol-5-ylcarbonyl or 3,4-dichloroisothiazol-5-ylcarbonyl (fragments from synthetic plant resistance activators tiadinil and isotianil, respectively) and a fragment of N-arylalanine, the toxophoric group of acylalanine fungicides. Several new synthesized compounds have shown moderate antifungal activity against fungi in vitro, such as B. cinerea, R. solani and S. sclerotiorum. In vivo tests against A. brassicicola showed that compound 1d was 92% effective at a concentration of 200 µg/mL, similar to level of tiadinil, a known inducer of systemic resistance. Thus, 1d could be considered a new candidate fungicide for further detailed study. The present results will advance research and influence the search for more promising fungicides for disease control in agriculture. © 2023 by the authors.Russian Science Foundation, RSF: 22-26-20124This research was supported by the Russian Science Foundation and Government of Sverdlovsk region, Joint Grant No 22-26-20124, https://rscf.ru/en/project/22-26-20124/ (accessed on 1 January 2023)

IDENTIFICATION AND STUDY OF LEPTOSPIROSIS FOCUS IN IRKUTSK REGION

Due to examination of animal breeding workers at the Irkutsk Region a case of human leptospirosis was identified. at the cattle farm of Tugutuy settlement. Due to epizootological-epidemiological study a mixed, leptospirosis focus in Ekhirit-Bulagat district was established, the agent circulation among commensal and wild, small mammals was demonstrated. Continuous pathogenic Leptospira DNA detection during the second, half of 2011, as well as the positive tularemia laboratory results require further study of the focus

POPULATION MORBIDITY BY INFECTIONS TRANSMITTED VIA IXODES PER-SULCATUS IN THE NORTH AND SOUTH OF IRKUTSK REGION

Aim. Evaluate the degree of epidemic risk of emergence of tick-borne encephalitis (TBE) and ixodes ticks’ borreliosis (ITB) in municipalities (MPs) of Irkutsk region with various natural-climate conditions. Materials and methods. Morbidity was compared for TBE and ITB during 2001 - 2015 in MPs of Irkutsk region located to the north or south of the 55th parallel, i.e. in the conditions of different severity of sharply continental climate. 5-year average data were analyzed. Results. ITB morbidity was 2 - 3 times higher than TBE for all the 5-year periods in the north of the region, whereas in the south -differences were not present. Moreover, in MPs located to the north of the 55th parallel in 2001 - 2015 a decrease of TBE and ITB morbidity did not occur, as in the south of the region. Conclusion. The lack of population morbidity reduction by TBE and ITB in the north and prevalence of the latter nosoform requires enhancement of a complex of prophylaxis measures in these MPs with an accent in development of non-specific means, including acaricidic treatment, enhancement of operations of centers of express diagnostics of transmissible infections, familiarizing of the population with the use of protective suits during periods of high activity of ticks