PROFESSIONAL DEVELOPMENT OF CIVIL SERVANTS IN THE CONTEXT OF THE DIGITAL TRANSFORMATION

Digital transformation in governance is possible subject to a change in the corporate culture of the federal authorities. Training and a modern system of professional development of public authorities based on digital solutions and requiring digital skills are becoming the most important tool for changing culture. At the same time, the digitalization of the processes of organizing the professional development of civil servants is impossible without improving this system, including building interconnection with the development strategy of the state body (sphere, department), the system for assessing and motivating civil servants, and their career development. The approaches to planning the professional development of civil servants, quality assessment and examination of educational programs require updating. These processes must be based on modern digital solutions and services. The object of the research is the activities of state bodies and subdivisions regulating the sphere of professional development of civil servants. The purpose of the study is to develop proposals for improving the system of professional development of public authorities in the context of the government digital transformation. The tasks are related to the analysis of the current state of the professional development system in public authorities, the development of proposals for improving the system of professional development in governance in the context of digitalization and client (citizen) centricity. The novelty of the research is determined by the introduction of new state data of the professional development system of civil servants and the proposed model of the system maturity levels under study. The research is based on a systemic approach and a comparative method. The following empirical methods are used: sociological research (in-depth interviews, polls of civil servants); analysis of documents, expert sessions; modeling. The result of the research was the development of proposals for improving the system of professional development in the aspect of creating unified methodological approaches to the professional development of civil servants. The main conclusions relate to the application of the maturity level model of this system and the possibility of its use to update the existing approaches and methodological tools. A special place is occupied by proposals for the improvement of the Unified Information System for Personnel Management of the State Civil Service of Russia (EISU KS) and the Unified Specialized Information Resource (EIR) services for professional development of civil servants. The results of research can be used in the interests of federal authorities and regional governments, the Office of the President of the Russian Federation for Civil 7 Service and Personnel, the Human Resources Department of the Government of the Russian Federation, the Ministry of Labor and Social Protection of the Russian Federation to improve work on the professional development of civil servants. The prospects of the study are associated with the implementation of the proposed model of maturity levels and the development of methodological tools for moving to higher levels in terms of organizing professional developmen

Ion channel TRPA₁ is a promising therapeutic target for treatment of pain

In the last time information about the role of TRPA₁ in pain and cold sensitivity, as well as in the formation and maintenance of inflammation is increasing in scientific literature. Given this information, the interest for search and study of pharmacological agents, which selectively blocked of TRPA₁ and reduced the severity of pain and inflammation is increasin

THEORETICAL APPROACHES TO THE STUDY OF FUNCTIONS, STRUCTURE AND ELEMENTS OF THE SYSTEM OF PROFESSIONAL CULTURE OF CIVIL SERVANTS

The object of the research is the functions, structure and elements of civil servants’ professional culture system. It is undergoing transformation, following the changes that public administration undergoes under the influence of a service/client-centric development trend that meets current societal transformations and the possibilities of the technological revolution. The goal of the study is to systematize the range of mechanisms for developing a modern professional culture of civil service, primarily from the standpoint of client-centricity. The objectives are to identify the clientcentered governance values, highlighting the main characteristics of the modern professional civil service culture, which can be treated as the fundamental basis for its development; analyze modern tools for the formation and development of key values of civil servants, including, first of all, the values of the client-centered state. The research method is the review of scientific and professional sources from the standpoint of their reflecting the conceptual and instrumental aspects of the formation of the professional civil service culture. As a result, numerous characteristics of the modern professional civil service culture are identified, which can be attributed to the fundamental basis for the development of a client-centered culture and are based on the generalization of foreign and Russian experience. An ecosystem approach to the formation and development of components of a client-centered professional civil service culture is proposed. The novelty of this research work is determined by the lack of Russian or foreign scientific studies of tools that would be directly focused on the development of a client-centered professional culture, as well as the technologies through which these tools are to be used. Theprospects are related to the relevance of the introduction of client-centricity in the Russian government agencies, in accordance with the testing of respective tools, which began in 2022. They are also related to the need to update the scientific agenda of the professional culture formation with the issue of the productivity of introducing the values of client-centricity into the activities of government authorities

Organizational Aspects of Social Rehabilitation of Minors with Deviant Behavior

The article reveals the social and psychological determinants that provoke the formation of deviant behavior of minors; highlights the organizational aspects of social rehabilitation activities for this category of children in social rehabilitation organizations.В статье раскрываются социальные и психологические детерминанты, провоцирующие формирование отклоняющегося поведения несовершеннолетних; освещаются организационные аспекты деятельности по социальной реабилитации данной категорией детей в социально-реабилитационных организациях

Minimisation of the viral contamination risk of heterologous immunoglobulins in the context of the requirements of the State Pharmacopoeia of the Russian Federation

To ensure the safety and to secure the approval of injectable medicinal products based on antigen-specific immunoglobulins of animal origin, it is necessary to exclude their contamination with adventitious human pathogens. Ensuring the viral safety of heterologous immunoglobulins presents a major challenge, because the State Pharmacopoeia of the Russian Federation, 14 edition, lacks production stage-specific viral safety requirements for such medicinal products. The aim of the study was to analyse the requirements set forth in general and individual monographs of the State Pharmacopoeia of the Russian Federation, the European Pharmacopoeia, (10th edition), the British Pharmacopoeia (2019), the United States Pharmacopoeia (USP 43–NF 38), the Japanese Pharmacopoeia (17th edition), as well as the recommendations of the European Medicines Agency and the World Health Organisation concerning the viral safety of medicinal products for human use based on heterologous antigen-specific immunoglobulins. The authors analysed regulatory requirements for the following: serum/plasma-producing animals; immunisation antigens for the animals; quarantine of the animals; viral contamination tests for immune animal serum/plasma pools; model viruses to validate viral inactivation/removal processes at different stages of vaccine production; viral load reduction at each inactivation/ removal step; testing of materials obtained at critical production stages. The authors drafted sections for quality standards on production stage-specific measures to minimise the viral contamination risk of medicinal products for human use based on heterologous immunoglobulins, which they proposed for inclusion to the State Pharmacopoeia of the Russian Federation

Characteristics of local immunity in infants

The state of immunity of infant depends on the nature of nutrition. To assess the state of local immune protection in infants, non-invasive methods are used. Infants fed with breast milk have additional protection against respiratory, intestinal, and urinal infections, as they receive sIgA with mother's milkСостояние иммунитета детей первого года жизни зависит от характера питания. Чтобы оценить состояние местной иммунной защиты у детей грудного возраста используют неинвазивные методы. Дети, вскармливаемые грудным молоком, имеют дополнительную защиту от возбудителей респираторных, кишечных и уринарных инфекций, так как получают sIgA с материнским молоко

Cholera in Azov area

The purpose of research is analysis of clinical course and treatment results of patients with cholera in the Azov area. Materials and methods. During the period from 29.05.2011 to 19.08.2011 33 cases of cholera (32 adults and 1 child) and 25 vibrio carriers (22 adults and 3 children), which were caused by toxigenic strains of Vibrio cholera El Tor serogroup O1 Ogawa. Results. Likely factors of disease transmission in Mariupol are sea and river water, and the fish that were caught in the waters of the city. Typical and watery diarrhoea, vomiting, abdominal pain and lack of normal body temperature, dehydration syndrome, characterized clinical cholera for adults in most cases. The mean duration of diarrhoea was 6,6 days. At 46.9% observed atypical symptoms in 10 (31,3%) – abdominal pain (1 patient cramping in 7 cases, localized in the epigastria region, at 2-over stomach). In 5 patients (15,6%) had an increase in body temperature to 37,2–37,7 degrees Celsius. In 15 (46,9%) patients had severe nausea accompanied by vomiting. Easy for cholera was observed in 1 (3.1%), moderate – in 14 (43,8%), heavy – in 17 (53,1%) patients. Dehydration I level is set at 4 (12,5%), II – from 6 (18,7%), III – in 18 (56,3%), IV – 4 (12,5%) patients. Cholera outbreak was characterized by a predominance of severe disease and severe dehydration (III and IV), which was observed in 68.8% of patients. The decisive factor in the treatment of cholera patients was initiated in a timely manner rehydration therapy, in particular the introduction of the solution «Trisol». Against the background of rehydration therapy hyperkalaemia was observed in 9,4% of cases, vascular rehydration at 9,4%, the cell rehydration in 3,1% of patients. Fatal accidents cholera outbreaks have not been observed. Conclusion. Clinical diagnosis of cholera and the provision of medical care in the prehospital phase were poor, indicating the need for systematic conducting training seminars among experts of ambulance, as well as doctors of primary medical network. Cholera hospitals (or base hospitals) must be equipped with a mobile diagnostics (ultrasound, X-rays) and modern laboratory equipment. The required list of drug supply cholera hospitals should be expanded in view of possible complications and comorbidities

Detection of symptom-related coronary arteries in patients with coronary artery disease using real-time three-dimensional stress echocardiography with adenosine triphosphate

Aim 1) To develop normative values of global and regional left ventricular longitudinal deformation (LVLD) during real time three-dimensional stress echocardiography with adenosine triphosphate (ATP) and utilization of automated function imaging technology (4D Stress-Echo + LVLD with ATP); 2) to compare the effectiveness of detection of symptom-related coronary arteries during 4D Stress-Echo with ATP using: a) traditional visual assessment of regional myocardial contractility and b) step-by-step analysis of segmental LVLD.Material and Methods 15 healthy subjects and 32 patients with coronary artery disease (CAD) were examined after coronary angiography. All individuals underwent 4D Stress-Echo + LVLD with ATP (Vivid E95, General Electric).Results The normative values of global LVLD at three stages of the pharmacological stress-test (before, during and after ATP infusion) were –19.5 (95% CI: -20.4 – -19.0), –21.6 (95% CI: -22.8 – -20.4) and –19.5 (95% CI: -20.3 – -18.6), respectively; the values of LVLD in each of the 17 segments of left ventricular myocardium in healthy subjects were also determined. In patients with CAD visual control of contractility during stress test revealed dynamic decrease in local thickening of the myocardium, appearance of new zones of contractility disorders and expansion of previously noted in 31.2% of cases, while analysis of deformation detected the appearance of new zones of deformation disturbances and expansion of previously found – in 68.7% (р = 0.0055). Stress-induced worsening of myocardial deformation during ATP infusion in the zones of blood supply of left anterior descending coronary artery, circumflex artery and right coronary artery (with presence of hemodynamically significant stenoses and occlusions detected during coronary angiography) were found in 28.0, 77.7 and 65.2% respectively (р1-3 = 0.0194; р1-2 = 0.0019; р2-3 = 0.2864).Conclusion The normal values of global and segmental LVLD for each stage of 4D Stress-Echo + LVLD with ATP were determined. 4D Stress-Echo + LVLD with ATP can significantly increase the effectiveness of symptom-related coronary arteries identification in patients with CAD in comparison with traditional Stress-Echo with visual assessment of local myocardial contractility

Nutrition status and development of infants and children of early age

The article presents the results of a complex estimation of health of 150 children and infants. In the study some children were identified abnormalities in nutritional status: the presence of alimentary-dependent conditions, a deficiency of one or more macro - and microelements in the urine (iodine, zinc, magnesium, iron, molybdenum, calcium). At most of children iodine deficiency of different degree of expressiveness is revealed. Correlation interrelations between the level of microcells and existence of deviations in a state of health of children are defined.В статье представлены результаты комплексной оценки здоровья 150 детей грудного и раннего возраста. В ходе исследования у части детей были выявлены отклонения в нутритивном статусе: наличие алиментарно-зависимых состояний, дефицит одного и более макро- и микроэлементов в моче (йода, цинка, магния, железа, молибдена, кальция). У большинства детей выявлен йодный дефицит разной степени выраженности. Найдены определенные корреляционные взаимосвязи между уровнем микроэлементов и наличием отклонений в состоянии здоровья детей