1,732 research outputs found
Extra-large crystal emulsion detectors for future large-scale experiments
Photographic emulsion is a particle tracking device which features the best
spatial resolution among particle detectors. For certain applications, for
example muon radiography, large-scale detectors are required. Therefore, a huge
surface has to be analyzed by means of automated optical microscopes. An
improvement of the readout speed is then a crucial point to make these
applications possible and the availability of a new type of photographic
emulsions featuring crystals of larger size is a way to pursue this program.
This would allow a lower magnification for the microscopes, a consequent larger
field of view resulting in a faster data analysis. In this framework, we
developed new kinds of emulsion detectors with a crystal size of 600-1000 nm,
namely 3-5 times larger than conventional ones, allowing a 25 times faster data
readout. The new photographic emulsions have shown a sufficient sensitivity and
a good signal to noise ratio. The proposed development opens the way to future
large-scale applications of the technology, e.g. 3D imaging of glacier bedrocks
or future neutrino experiments.Comment: Version accepted for publication in JINS
Aggregation number distributions and mesoglobules in dilute solutions of diblock and triblock copolymers
We investigate the aggregation number and size distributions for
inter-molecular clusters of amphiphilic diblock and triblock copolymers in poor
solvent at very low concentrations. Diblocks and triblocks with hydrophilic
ends are shown to possess narrow distributions corresponding to formation of
monodispersed mesoglobules. Diblocks with hydrophobic ends are found to produce
inter-cluster multimers due to bridging by the hydrophilic middle blocks,
resulting in polydisperse distributions. Implications of these observations for
preparation of monodispersed nanoparticles and, potentially, understanding of
the quaternary structure of proteins are discussed.Comment: 4 pages, 4 PS figures. Accepted for publication in EP
Association analysis of tissue inhibitor of metalloproteinase2 gene polymorphisms with COPD in Egyptians
AbstractProteinase/antiproteinase imbalance is recognized to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). A relative increase in the activities of matrix metalloproteinases might be caused by mutations of tissue inhibitor of metalloproteinase2 (TIMP2). Recently, two polymorphisms of the TIMP2 gene, +853 G/A and â418 G/C (+551 and â720 from the translation initiation site), have been shown to be associated with the development of COPD in the Japanese population. In this study, a case-control association analysis for these polymorphisms was conducted in the Egyptian population using 106 COPD patients and 72 healthy controls. The genotype frequency of +853 G/A was significantly different between the patient and the control groups (P=0.029), although no significant difference was detected in the allele frequency between the two groups. These results suggest that the +853 G/A polymorphism of the TIMP2 gene might be associated with COPD across ethnicities. In contrast, neither the distributions of genotype nor allele frequencies of â418 G/C were significantly different between the two groups, raising the possibility that a combination of different genetic factors contributes to the development of COPD in different ethnic groups
Cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection
We report the systemic cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection. In patients with pneumonia, the serum levels of IFN-Îł and IL-5 were significantly higher than those in patients without pneumonia. This tendency was also present for IL-6, IL-8, IL-10, IL-13, and MCP-1 in patients with pneumonia. Among patients with pneumonia, the levels of MCP-1 were significantly higher in the group of patients with pneumonia with severe respiratory failure than patients with mild pneumonia
A reversible lesion of the corpus callosum splenium with adult influenza-associated encephalitis/encephalopathy: a case report
<p>ABstract</p> <p>Introduction</p> <p>Influenza virus-associated encephalitis/encephalopathy is a severe childhood illness with a poor prognosis. Adult case reports are rare and, to date, there have been no reports of adults with a mild subcortical encephalopathy with reversible lesions of the corpus callosum splenium.</p> <p>Case presentation</p> <p>A previously healthy 35-year-old man presented with acute progressive tetraplegia, transcortical motor aphasia and a mild decrease in his consciousness during his recovery after receiving oseltamivir phosphate treatment, and influenza type A antiviral medication. The initial magnetic resonance imaging study at day 1 showed symmetrical diffuse lesions in the white matter and a lesion on the central portion of the corpus callosum splenium. These findings had resolved on follow-up studies at day 8 and day 146. His neurological deficits mostly recovered within 12 hours following methylprednisolone pulse therapy. The levels of interleukin-6 and interleukin-10 in his blood and cerebrospinal fluid were initially elevated, but rapidly decreased to normal levels by day 8.</p> <p>Conclusion</p> <p>It is important for clinicians to recognize that even in adulthood, the subcortical encephalopathy observed during the therapeutic treatment for influenza type A infection can occur in conjunction with a reversible lesion of the corpus callosum, which may recover quickly. In addition, the cytokine storm in the blood system and the corticospinal cavity may play an important role in the etiology of the disease process.</p
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