1,529 research outputs found
Tetramer Orbital-Ordering induced Lattice-Chirality in Ferrimagnetic, Polar MnTi2O4
Using density-functional theory calculations and experimental investigations
on structural, magnetic and dielectric properties, we have elucidated a unique
tetragonal ground state for MnTi2O4, a Ti^{3+} (3d^1)-ion containing
spinel-oxide. With lowering of temperature around 164 K, cubic MnTi2O4
undergoes a structural transition into a polar P4_1 tetragonal structure and at
further lower temperatures, around 45 K, the system undergoes a paramagnetic to
ferrimagnetic transition. Magnetic superexchange interactions involving Mn and
Ti spins and minimization of strain energy associated with co-operative
Jahn-Teller distortions plays a critical role in stabilization of the unique
tetramer-orbital ordered ground state which further gives rise to lattice
chirality through subtle Ti-Ti bond-length modulations
Self-Energy Effects on the Low- to High-Energy Electronic Structure of SrVO3
The correlated electronic structure of SrVO3 has been investigated by
angle-resolved photoemission spectroscopy using in-situ prepared thin films.
Pronounced features of band renormalization have been observed: a sharp kink
~60 meV below the Fermi level (EF) and a broad so-called "high-energy kink"
~0.3 eV below EF as in the high-Tc cuprates although SrVO3 does not show
magnetic fluctuations. We have deduced the self-energy in a wide energy range
by applying the Kramers-Kronig relation to the observed spectra. The obtained
self-energy clearly shows a large energy scale of ~0.7 eV which is attributed
to electron-electron interaction and gives rise to the ~0.3 eV "kink" in the
band dispersion as well as the incoherent peak ~1.5eV below EF. The present
analysis enables us to obtain consistent picture both for the incoherent
spectra and the band renormalization.Comment: 5 pages, 3 figure
Observational Signature of Tidal Disruption of a Star by a Massive Black Hole
We have modeled the time-variable profiles of the Halpha emission line from
the non-axisymmetric disk and debris tail created in the tidal disruption of a
solar-type star by a million solar mass black hole. We find that the line
profiles at these very early stages of the evolution of the post-disruption
debris do not resemble the double peaked profiles expected from a rotating disk
since the debris has not yet settled into such a stable structure. The
predicted line profiles vary on fairly short time scales (of order hours to
days). As a result of the uneven distribution of the debris and the existence
of a ``tidal tail'' (the stream of returning debris), the line profiles depend
sensitively on the orientation of the tail relative to the line of sight. Given
the illuminating UV/X-ray light curve, we also model the Halpha light curve
from the debris.Comment: 2 pages, 1 figure, to appear in the proceedings of "The Interplay
among Black Holes, Stars and ISM in Galactic Nuclei", IAU 222, eds. Th.
Storchi Bergmann, L.C. Ho, and H.R. Schmit
SYNTHESIS, IN VITRO ANTIBACTERIAL, TOXICITY AND MOLECULAR DOCKING ANTICANCER ACTIVITY OF NOVEL N-[(2-CHLOROQUINOLIN-3-YL) METHYLIDENE]-2-ANILINE SCHIFF'S BASES
Objective: Synthesis of N-[(2-chloroquinolin-3-yl) methylidene]-2-aniline schiff bases (3a-j) and to study their in vitro antibacterial activity and in silico study towards cancer and malarial proteins.
Methods: Various N-[(2-chloroquinolin-3-yl) methylidene]-2-aniline schiff bases (3a-j) were synthesized by using 2-chloro-3-formyl quinoline and different anilines in presence of acetic acid as catalyst. All the new compounds were characterized by 1H-NMR, [13]C-NMR and LCMS analysis. The compounds 3a-j was subjected to antibacterial activity. In silico molecular properties were predicted using various online cheminformatic tools, the binding interactions with Human DNA topoisomerase I and Plasmodium falciparum lactate dehydrogenase proteins was studied through molecular docking and Irinotecan and mefloquine were used as reference drugs.
Results: Fairly good yield of N-[(2-chloroquinolin-3-yl) methylidene]-2-aniline schiff bases (3a-j) were synthesized by convenient and economical procedure. The preliminary in silico pharmacokinetics study reveals that the compounds 3a-j shows excellent drug like property. The toxicity profile of compounds 3a-h was found safe. The compounds 3a-j was exhibited promising MIC values against the both S. aureus and E. coli. Similarly the docking results predict that the compound 3d shown highest interaction by forming two hydrogen bonds against the cancer protein with the interaction energy-20.696 kcal/mol. Compound 3c exhibits highest dock score of-45.703 kcal/mol with two hydrogen bonds against malarial protein.
Conclusion: From the results of docking studies of N-[(2-chloroquinolin-3-yl) methylidene]-2-aniline schiff bases (3a-j), it has been concluded that the compounds were found to exhibit multifunctional lead property, hence these compounds are worth to be considered as potential lead molecules for further study
SYNTHESIS AND MOLECULAR DOCKING STUDY OF 2-ARYL/HETEROARYL-6-CHLOROQUINOLINE-4-CARBOXYLIC ACIDS WITH PLASMODIUM LDH RECEPTOR PROTEIN
Objective: Synthesis and in silico molecular docking studies of 2-aryl/heteroaryl-quinoline-4-carboxylic acid derivatives (3a-j) with plasmodium LDH receptor protein.Methods: The 2-aryl/heteroaryl-quinoline-4-carboxylic acids (3a-j) were obtained by Pfitzinger reaction. Ligands (3a-j) interaction with plasmodium LDH receptor protein was studied through molecular docking method.Results: Good yields of 2-aryl/heteroaryl-quinoline-4-carboxylic acid derivatives (3a-j) were obtained by convenient and economical procedure. Their structures were confirmed by 1H NMR, 13C NMR, and MS spectral analysis. The binding site analysis of the synthesized compounds (3a-j) with plasmodium LDH receptor that are responsible for malaria parasite response was evaluated through molecular docking study. The results reveal that the ligand 3d shows maximum of five hydrogen bonding interactions with binding energy -9.05 kcal/mol, shown to be a promising lead molecule to inhibit Plasmodium LDH receptor.Conclusion: The docking studies of newly synthesized 2-aryl/heteroaryl-quinoline-4-carboxylic acids were found to be very useful ligands for antimalarial therapy particularly on Plasmodium LDH protein. However the installation of still many appropriate substitutions on quinoline moiety would lead to identification of novel antimalarial compounds that ascertained via molecular docking is underway in our lab
Electromigration-Induced Propagation of Nonlinear Surface Waves
Due to the effects of surface electromigration, waves can propagate over the
free surface of a current-carrying metallic or semiconducting film of thickness
h_0. In this paper, waves of finite amplitude, and slow modulations of these
waves, are studied. Periodic wave trains of finite amplitude are found, as well
as their dispersion relation. If the film material is isotropic, a wave train
with wavelength lambda is unstable if lambda/h_0 < 3.9027..., and is otherwise
marginally stable. The equation of motion for slow modulations of a finite
amplitude, periodic wave train is shown to be the nonlinear Schrodinger
equation. As a result, envelope solitons can travel over the film's surface.Comment: 13 pages, 2 figures. To appear in Phys. Rev.
Origin of G-type Antiferromagnetism and Orbital-Spin Structures in
The possibility of the distortion of octahedra is
examined theoretically in order to understand the origin of the G-type
antiferromagnetism (AFM(G)) and experimentally observed puzzling properties of
. By utilizing an effective spin and pseudospin Hamiltonian with
the strong Coulomb repulsion, it is shown that AFM(G) state is stabilized
through the lift of the -orbital degeneracy accompanied by a tiny
-distortion . The estimated spin-exchange interaction is in agreement
with that obtained by the neutron scattering. Moreover, the level-splitting
energy due to the distortion can be considerably larger than the spin-orbit
interaction even when the distortion becomes smaller than the detectable limit
under the available experimental resolution. This suggests that the orbital
momentum is fully quenched and the relativistic spin-orbit interaction is not
effective in this system, in agreement with recent neutron-scattering
experiment.Comment: 9 pages, 6 figure
Fingerprints of Spin-Orbital Physics in Crystalline O
The alkali hyperoxide KO is a molecular analog of strongly-correlated
systems, comprising of orbitally degenerate magnetic O ions. Using
first-principles electronic structure calculations, we set up an effective
spin-orbital model for the low-energy \textit{molecular} orbitals and argue
that many anomalous properties of KO replicate the status of its orbital
system in various temperature regimes.Comment: 4 pages, 2 figures, 1 tabl
Microscopic origin of diagonal stripe phases in doped nickelates
We investigate the electron density distribution and the stability of stripe
phases in the realistic two-band model with hopping elements between e_g
orbitals at Ni sites on the square lattice, and compare these results with
those obtained for the doubly degenerate Hubbard model with two equivalent
orbitals and diagonal hopping. For both models we determine the stability
regions of filled and half-filled stripe phases for increasing hole doping
x=2-n in the range of x<0.4, using Hartree-Fock approximation for large
clusters. In the parameter range relevant to the nickelates, we obtain the most
stable diagonal stripe structures with filling of nearly one hole per atom, as
observed experimentally. In contrast, for the doubly degenerate Hubbard model
the most stable stripes are somewhat reminiscent of the cuprates, with
half-filled atoms at the domain wall sites. This difference elucidates the
crucial role of the off-diagonal e_g hopping terms for the stripe formation in
La_2-xSr_xNiO_4. The influence of crystal field is discussed as well.Comment: 15 pages, 12 figure
Bias reduction in traceroute sampling: towards a more accurate map of the Internet
Traceroute sampling is an important technique in exploring the internet
router graph and the autonomous system graph. Although it is one of the primary
techniques used in calculating statistics about the internet, it can introduce
bias that corrupts these estimates. This paper reports on a theoretical and
experimental investigation of a new technique to reduce the bias of traceroute
sampling when estimating the degree distribution. We develop a new estimator
for the degree of a node in a traceroute-sampled graph; validate the estimator
theoretically in Erdos-Renyi graphs and, through computer experiments, for a
wider range of graphs; and apply it to produce a new picture of the degree
distribution of the autonomous system graph.Comment: 12 pages, 3 figure
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