Dynamic organization schemes for cooperative proxy caching

In a generic cooperative caching architecture, web proxies form a mesh network. When a proxy cannot satisfy a request, it forwards the request to the other nodes of the mesh. Since a local cache cannot fulfill the majority of the arriving requests (typical values of the local hit ratio are about 30-50%), the volume of queries diverted to neighboring nodes can substantially grow and may consume considerable amount of system resources. A proxy does not need to cooperate with every node of the mesh due to the following reasons: (i) the traffic characteristics may be highly diverse; (ii) the contents of some nodes may extensively overlap; (iii) the inter-node distance might be too large. Furthermore, organizing N proxies in a mesh topology introduces scalability problems, since the number of queries is of the order of N/sup 2/. Therefore, restricting the number of neighbors for each proxy to k < N - 1 will likely lead to a balanced trade-off between query overhead and hit ratio, provided cooperation is done among useful neighbors. For a number of reasons the selection of useful neighbors is not efficient. An obvious reason is that web access patterns change dynamically. Furthermore, availability of proxies is not always globally known. This paper proposes a set of algorithms that enable proxies to independently explore the network and choose the k most beneficial (according to local criteria) neighbors in a dynamic fashion. The simulation experiments illustrate that the proposed dynamic neighbor reconfiguration schemes significantly reduce the overhead incurred by the mesh topology while yielding higher hit ratios compared to the static approach.published_or_final_versio

A general framework for searching in distributed data repositories

This paper proposes a general framework for searching large distributed repositories. Examples of such repositories include sites with music/video content, distributed digital libraries, distributed caching systems, etc. The framework is based on the concept of neighborhood; each client keeps a list of the most beneficial sites according to past experience, which are visited first when the client searches for some particular content. Exploration methods continuously update the neighborhoods in order to follow changes in access patterns. Depending on the application, several variations of search and exploration processes are proposed. Experimental evaluation demonstrates the benefits of the framework in different scenarios.published_or_final_versio

CEO Education and the Ability to Raise Capital

Research Question/Issue: Using a unique hand‐collected dataset, this study examines the role of Chief Executive Officer (CEO) educational attainments in relation to newly public firms. Research Findings/Insights: We find that Initial Public Offering (IPO) firms led by CEOs with superior educational credentials — in terms of level and quality — are associated with lower levels of IPO underpricing. This association is mainly driven by CEOs that hold advanced degrees. Notably, a difference‐in‐difference approach based on two quasi‐natural experiments indicates that the impact of CEO education on IPO underpricing is more pronounced within environments characterized by lower information transparency. The baseline results also hold in the longer term, thereby confirming the value of signaling prestigious academic awards at the time of the IPO. Theoretical/Academic Implications: Using human capital, institutional and upper echelon theories, we hypothesize and demonstrate that CEO educational attainments do not unambiguously affect investors’ perceptions of a firm's future prospects. Instead, their influence depends on the quality of CEO education as well as on the degree of uncertainty regarding the firm's future performance, and the level of information asymmetry between issuers and prospective investors. To our knowledge, this is the first study that provides a comprehensive treatment of the role of CEO education in the IPO context. Practitioner/Policy Implications: Our evidence on the importance of CEO education, and especially that CEOs with varying levels and quality of educational training might differentially affect newly listed firms, is useful to providers of financial capital and boards of directors interested in assessing the viability of new ventures. The implication of our study for IPO investors is that it is worth paying more to take an equity position in firms run by better‐educated CEOs

Non-adaptive Measurement-based Quantum Computation and Multi-party Bell Inequalities

Quantum correlations exhibit behaviour that cannot be resolved with a local hidden variable picture of the world. In quantum information, they are also used as resources for information processing tasks, such as Measurement-based Quantum Computation (MQC). In MQC, universal quantum computation can be achieved via adaptive measurements on a suitable entangled resource state. In this paper, we look at a version of MQC in which we remove the adaptivity of measurements and aim to understand what computational abilities still remain in the resource. We show that there are explicit connections between this model of computation and the question of non-classicality in quantum correlations. We demonstrate this by focussing on deterministic computation of Boolean functions, in which natural generalisations of the Greenberger-Horne-Zeilinger (GHZ) paradox emerge; we then explore probabilistic computation, via which multipartite Bell Inequalities can be defined. We use this correspondence to define families of multi-party Bell inequalities, which we show to have a number of interesting contrasting properties.Comment: 13 pages, 4 figures, final version accepted for publicatio

Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer

Alteration in transforming growth factor-β signalling pathway is one of the main causes of pancreatic cancer. The human runt-related transcription factor 3 gene (RUNX3) is an important component of this pathway. RUNX3 locus 1p36 is commonly deleted in a variety of human cancers, including pancreatic cancer. Therefore, we examined genetic and epigenetic alterations of RUNX3 in human pancreatic cancer. Thirty-two patients with pancreatic cancer were investigated in this study. We examined the methylation status of RUNX3 promoter region, loss of heterozygosity (LOH) at 1p36, and conducted a mutation analysis. The results were compared with clinicopathological data. Promoter hypermethylation was detected in 20 (62.5%) of 32 pancreatic cancer tissues, confirmed by sequence of bisulphite-treated DNA. Loss of heterozygosity was detected in 11 (34.3%) of 32 pancreatic cancers. In comparison with clinicopathological data, hypermethylation showed a relation with a worse prognosis (P=0.0143). Hypermethylation and LOH appear to be common mechanisms for inactivation of RUNX3 in pancreatic cancer. Therefore, RUNX3 may be an important tumour suppressor gene related to pancreatic cancer

The Influence of a Firms\u27 Business Strategy on the Downside Risk of Earnings, Accruals and Cash Flow

This study examines whether a firm\u27s business strategy is an underlying determinant of downside risk in accounting earnings and its components. Based on organizational theory we predict that firms following an innovative prospector strategy exhibit lower profitability tendencies than firms following a cost-oriented defender strategy. Further, we anticipate that these strategies are asymmetrically positioned towards environmental uncertainty, with defenders focusing their efforts to efficiency, cost control, and minimizing exposure to downside risk, whereas prospectors direct their resources to flexibility, innovation, and maximizing the growth potential through aggressive expansion to new product markets. We find that prospectors are indeed less profitable than defenders. We also demonstrate that prospectors have greater total and downside earnings risk. Finally, we decompose earnings into accruals and cash flow and show that the higher exposure of prospectors to earnings downside risk is driven by the cash flow component rather than the accrual component. Collectively, our results suggest that considering how strategy interacts with financial reporting attributes is a useful way for evaluating a firms\u27 risk profile

Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy

Snail2 is a marker of malignancy in epithelial tumours; however, in sarcomas, it is not known if this protein is present. Here we examine the expression of Snail2 in one type of sarcoma, osteosarcoma, and explore its relationship to tumour grade, subtype and anatomical location in cases of long bone and cranial bone osteosarcoma. Long bone osteosarcomas typically have a much greater metastatic capability and a poorer prognosis. We find that Snail2 is expressed in the three main subtypes of long bone osteosarcoma—osteoblastic, chondroblastic and fibroblastic. Regression analysis showed that Snail 2 expression was statistically correlated with tumour grade (p = 0.014) in all of these subtypes. Snail2 was only expressed in high-grade cranial bone osteosarcomas, suggesting a link between Snail2 expression and metastasis. This is the first time Snail2 has been associated with any sarcoma, and this study shows that Snail2 may be a useful prognostic marker for this disease

Identification of novel candidate target genes, including EPHB3, MASP1 and SST at 3q26.2–q29 in squamous cell carcinoma of the lung

<p>Abstract</p> <p>Background</p> <p>The underlying genetic alterations for squamous cell carcinoma (SCC) and adenocarcinoma (AC) carcinogenesis are largely unknown.</p> <p>Methods</p> <p>High-resolution array- CGH was performed to identify the differences in the patterns of genomic imbalances between SCC and AC of non-small cell lung cancer (NSCLC).</p> <p>Results</p> <p>On a genome-wide profile, SCCs showed higher frequency of gains than ACs (<it>p </it>= 0.067). More specifically, statistically significant differences were observed across the histologic subtypes for gains at 2q14.2, 3q26.2–q29, 12p13.2–p13.33, and 19p13.3, as well as losses at 3p26.2–p26.3, 16p13.11, and 17p11.2 in SCC, and gains at 7q22.1 and losses at 15q22.2–q25.2 occurred in AC (<it>P </it>< 0.05). The most striking difference between SCC and AC was gains at the 3q26.2–q29, occurring in 86% (19/22) of SCCs, but in only 21% (3/14) of ACs. Many significant genes at the 3q26.2–q29 regions previously linked to a specific histology, such as EVI1,<it>MDS1, PIK3CA </it>and <it>TP73L</it>, were observed in SCC (<it>P </it>< 0.05). In addition, we identified the following possible target genes (> 30% of patients) at 3q26.2–q29: <it>LOC389174 </it>(3q26.2),<it>KCNMB3 </it>(3q26.32),<it>EPHB3 </it>(3q27.1), <it>MASP1 </it>and <it>SST </it>(3q27.3), <it>LPP </it>and <it>FGF12 </it>(3q28), and <it>OPA1</it>,<it>KIAA022</it>,<it>LOC220729</it>, <it>LOC440996</it>,<it>LOC440997</it>, and <it>LOC440998 </it>(3q29), all of which were significantly targeted in SCC (<it>P </it>< 0.05). Among these same genes, high-level amplifications were detected for the gene, <it>EPHB3</it>, at 3q27.1, and <it>MASP1 </it>and <it>SST</it>, at 3q27.3 (18, 18, and 14%, respectively). Quantitative real time PCR demonstrated array CGH detected potential candidate genes that were over expressed in SCCs.</p> <p>Conclusion</p> <p>Using whole-genome array CGH, we have successfully identified significant differences and unique information of chromosomal signatures prevalent between the SCC and AC subtypes of NSCLC. The newly identified candidate target genes may prove to be highly attractive candidate molecular markers for the classification of NSCLC histologic subtypes, and could potentially contribute to the pathogenesis of the squamous cell carcinoma of the lung.</p

Modelos explicativos da memória prospectiva: uma revisão teórica

Neste artigo é apresentada uma revisão da literatura sobre os mecanismos cognitivos associados à memória prospectiva, organizados de acordo com a divisão das diferentes fases da recordação prospectiva (i.e., codificação, retenção e recuperação). Inicialmente, é apresentada a diversidade de dados da investigação que sustentam diferentes abordagens explicativas do fenômeno de recuperação de intenções, considerando a natureza automática ou estratégica da memória prospectiva. Em seguida, são salientadas as potenciais explicações sobre os mecanismos presentes durante o intervalo de retenção e na fase de codificação.(undefined