The preparation of new perfluoroether fluids exhibiting excellent thermal-oxidative stabilities

A series of low molecular weight perfluoroalkylethers (PFAE) were synthesized by direct fluorination. Viscosity-temperature properties and oxidation stabilities were determined. Viscosity-temperature correlations indicated that increases in branching and increases in the size of the branching substituent caused a deterioration in viscometric properties (i.e., an increase in ASTM slope). In addition, increasing the ratio of carbon to oxygen in these compounds also increased the ASTM slope. Preliminary oxidation stability tests indicated that highly branched PFAE fluids. (i.e., those containing quaternary carbons) may be less stable than either those containing a single trifluoromethyl pendant group or those containing no branching at all

Inhibitory effect of 22-oxa-1,25-dihydroxyvitamin D-3, maxacalcitol, on the proliferation of pancreatic cancer cell lines

ArticleJOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 97(1-2): 173-177 (2005)journal articl

IgG4-related sclerosing cholangitis should be included as an exclusion criterion for the diagnosis of primary sclerosing cholangitis

The definitive version is available at www.blackwell-synergy.com.ArticleAMERICAN JOURNAL OF GASTROENTEROLOGY. 102(3): 691-692 (2007)journal articl

65/Detektory MOSFET jako narzędzie do weryfikowania dawek terapeutycznych wiązek elektronów w radioterapii

CelZastosowanie detektorów MOSFET (Metal – Oxide Semiconductor Field Effect Transistor) do pomiaru dawki in vivo wiązek elektronów w radioterapii.Metody i materiałyWykonano pomiary fantomowe polegające na zbadaniu zależności wskazań detektorów MOSFET od: – wartości dawki wiązek elektronów, – temperatury otoczenia detektorów, – kierunku padania wiązki elektronów na detektor, – wielkości napromienianego pola.Zbadano także zmianę czułości detektorów w zależności od skumulowanej dawki. Detektory, ze względu na bardzo małe wymiary, umieszczano w odpowiednio zaprojektowanych nakładkach aluminiowych – w celu zapewnienia równowagi elektronowej podczas pomiaru dawki. Wskazania detektorów porównywano do wskazańkomory jonizacyjnej typu Markus, posiadającej świadectwowzorcowania. Pomiary wykonano z użyciem wiązek elektronów o energii 6, 9, 12, 15, 18,21 MeV.WynikiZbadane zależności i określone na ich podstawie współczynniki korekcyjne umożliwiają zmierzyć dawkę wiązki elektronów z dokładnością ±2.5%.WniosekDetektory MOSFET są dobrym narzędziemdo weryfikowania dawki wejściowej w radioterapii wiązkami elektronów

Seronegative Sjogren syndrome with asymptomatic autoimmune sclerosing pancreatitis

The original publication is available at www.springerlink.com.ArticleCLINICAL RHEUMATOLOGY. 26(1): 117-119 (2007)journal articl

Effect of short-term school closures on the H1N1 pandemic in Japan: a comparative case study

Purpose The 2009 worldwide influenza A/H1N1 pandemic particularly affected younger people, including schoolchildren. We assessed the effects of class/school closure during the pandemic on the spread of H1N1 infection in Japan. Methods We prospectively monitored 2,141 schoolchildren in 57 classes at two elementary schools and two junior high schools in Japan, and evaluated the effects of class/school closures on the spread of H1N1 using descriptive epidemiological methods. Results The cumulative rate of H1N1 infection among these children was 40.9 % (876 children). There was a total of 53 closures of 40 classes, including school closures, during the pandemic. Time-course changes in the epidemic curve showed that school closure reduced the following epidemic peak more than class closure. A Poisson regression model showed that a longer duration of closure was significantly related to decreased H1N1 occurrence after the resumption of classes. Conclusions School closure more effectively inhibits subsequent epidemic outbreaks than class closure. Longer school closures are effective in reducing the spread of infection, and school closure should be implemented as early as possible.ArticleINFECTION. 40(5):549-556 (2012)journal articl

Pancreatic exocrine insufficiency: a rare cause of nonalcoholic steatohepatitis

This is an electronic version of an Article published in the American Journal of Gastroenterology 2008; 103(1): 245-246.ArticleAmerican journal of gastroenterology. 103(1): 245-246 (2008)journal articl

A Novel Heterophilic Antibody Interaction Involves IgG4

IgG4 has been implicated in a diverse set of complex pathologies - e.g. autoimmune pancreatitis (AIP), idiopathic membranous nephropathy - and carries unique features including lack of activation of the classical complement pathway and a dynamic Fab-arm exchange. We recently showed that the rheumatoid factor (RF)-like activity of IgG4 is achieved through a hitherto unknown, Fc-Fc (and not Fab-Fc as is the case in classical RF; CRF) interaction; hence the name, novel RF (NRF). Here, we further explore the resemblance/difference between CRF and NRF. As heterophilic interactions of human IgM RF (CRF) are well known, we checked whether this is the case for IgG4. Human IgG4 showed variable reactivity to animal IgGs: reacting intensely with rabbit and mouse IgGs, but weakly with others. The binding to rabbit IgG was not through the Fab (as in CRF) but via the Fc piece, as was recently shown for human IgG (NRF). This binding correlates with the IgG4 concentration per se and could therefore be of diagnostic usage and incidentally explain some observed interferences in biological assays. In conclusion, here is defined a novel heterophilic antibody interaction and is established the universality of the unique Fc-Fc binding, both involving IgG4.ArticleSCANDINAVIAN JOURNAL OF IMMUNOLOGY. 71(2):109-114 (2010)journal articl

Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis

The original publication is available at www.springerlink.com.ArticleJOURNAL OF GASTROENTEROLOGY. 41(12): 1197-1205 (2006)journal articl

Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients

ArticleAMERICAN JOURNAL OF GASTROENTEROLOGY. 103(3):588-594 (2008)journal articl