Charged rho meson production in neutrino-induced reactions at E_nu = 10 GeV

The neutrinoproduction of charged $\rho$ mesons on nuclei and nucleons is investigated for the first time at moderate energies ($\approx$ 10 GeV), using the date obtained with SKAT bubble chamber. No strong nuclear effects are observed in $\rho^+$ and $\rho^-$ production. The fractions of charged and neutral pions originating from $\rho$ decays are obtained and compared with higher energy data. From analysis of the obtained and available data on $\rho^+$ and $K^{*+}$(892) neutrinoproduction, the strangeness suppression factor in the quark string fragmentation is extracted: $\lambda_s = 0.18\pm0.03$. Estimations are obtained for cross sections of quasiexclusive single $\rho^+$ and coherent $\rho^+$ neutrinoproduction on nuclei. The estimated coherent cross section $\sigma_{\rho^+}^{coh}$ = (0.29$\pm0.16)\cdot 10^{-38}$ cm$^2$ is compatible with theoretical predictions.Comment: 7 pages, 6 figure

A study of the nuclear medium influence on transverse momentum of hadrons produced in deep inelastic neutrino scattering

The influence of nuclear effects on the transverse momentum $(p_T)$ distributions of neutrinoproduced hadrons is investigated using the data obtained with SKAT propane-freon bubble chamber irradiated in the neutrino beam (with $E_{\nu}$ = 3-30 GeV) at Serpukhov accelerator. Dependences of $$on the kinematical variables of inclusive deep-inelastic scattering and of the produced hadrons are measured. It has been observed, that the nuclear effects cause an enhancement of$$ of hadrons (more pronounced for the positively charged ones) produced in the target fragmentation region at low invariant mass of the hadronic system (2 $< W <$ 4 GeV) or at low energies transferred to the current quark (2 $< \nu < 9$ GeV). At higher $W$ or $\nu$, no influence of nuclear effects on $$ is observed. Measurement results are compared with predictions of a simple model, incorporating secondary intranuclear interactions of hadrons (with a formation length extracted from the Lund fragmentation model), which qualitatively reproduces the main features of the data.Comment: 23 pages, 7 figure

The total yields of K^+(892), Sigma^+(1385) and Sigma^0 in neutrino-induced reactions at <E_nu> = 10 GeV

Using the data obtained with SKAT bubble chamber, the total yields of $K^+(892)$, $\Sigma^+(1385)$ and $\Sigma^0$ are estimated for the first time in neutrino-induced reactions at moderate energies ($$ = 10.4 GeV). It is shown, that the recently observed \cite{ref1,ref2} enhancement of the $K^0$ and $\Lambda$ yields in $\nu A$ interactions (as compared to $\nu N$ interactions) is contributed only slightly by the $K^+(892)$ and $\Sigma^+(1385)$ production, respectively. The decay contribution to the $K^0$ and $\Lambda$ yields is found to be in qualitative agreement with higher energy ($\geq$ 40 GeV) data. It is shown, that the energy dependence of the $K^+(892)$ mean multiplicity in $\nu N$ interactions is approximately linear in the range of $\approx$ 10-60 GeV, while that for $\Sigma^0$ in $\nu A$ interactions (for $A$ = 20-21) is approximately logarithmic in the range of $\approx$ 10-150 GeV.Comment: 6 pages, 3 figure

The A - dependence of K0K^{0} and Λ\Lambda neutrinoproduction on nuclei

For the first time, the A- dependence of the production of $K^0$, $\Lambda$ and, for comparison, $\pi^-$ mesons is investigated in neutrinonuclear reactions, using the data obtained with SKAT bubble chamber. An exponential parametrization ($\sim A^{\beta}$) of the particle yields results in ${\beta}_{V^0} = 0.20 \pm 0.05$ for $V^0$ particles (combined $K^0$ and $\Lambda$), while for $\pi^-$ mesons the A- dependence is much weaker, ${\beta}_{\pi^-} = 0.068 \pm 0.007$. A nuclear enhancement of the ratio $K^0/\pi^-$ is found; this ratio increases from $0.055 \pm 0.013$ for $\nu N$- interactions up to $0.070 \pm 0.011$ at $A \approx 21$ and $0.099 \pm 0.011$ at $A \approx 45$. It is observed, that the multiplicity rise of $V^0$'s occures predominantely in the backward hemisphere of the hadronic c.m.s. It is shown, that the A- dependence of the nuclear enhancement of the ${\Lambda}^0$ and $\pi^-$ yields can be reproduced in the framework of a model, incorporating the secondary intranuclear interactions of pions originating from the primary $\nu N$- interactions, while only (29$\pm$9)% of that for $K^0$ at $A \approx 45$ can be attributed to intranuclear interactions.Comment: 18 pages, 8 figure

The yields of light meson resonances in neutrinonuclear interactions at <E_nu> = 10 GeV

The total yields of the all well-established light mesonic resonances (up to the $\phi$(1020) meson) are estimated in neutrinonuclear interactions at < E_nu > = 10 GeV, using the data obtained with SKAT bubble chamber. For some resonances, the yields in the forward and backward hemispheres in the hadronic c.m.s. are also extracted. From the comparison of the obtained and available higher-energy data, an indication is obtained that the resonance yields rise almost linearly as a function of the mean mass of the neutrinoproduced hadronic system. The fractions of pions originating from the light resonance decays are inferred.Comment: 15 pages, 7 figure

Vitamin D serum level predicts stroke clinical severity, functional independence, and disability—A retrospective cohort study

BackgroundStroke is a leading cause of mortality and disability and one of the most common neurological conditions globally. Many studies focused on vitamin D as a stroke risk factor, but only a few focused on its serum level as a predictor of stroke initial clinical severity and recovery with inconsistent results. The purpose of this study was to assess the relationship between serum vitamin D levels and stroke clinical severity at admission and functional independence and disability at discharge in Saudi Arabia.MethodologyA retrospective cohort study of adult ischemic stroke patients who had their vitamin D tested and admitted within 7 days of exhibiting stroke symptoms at King Abdulaziz Medical City (KAMC) Jeddah, Saudi Arabia. Based on vitamin D level, the patients were categorized into normal [25(OH)D serum level ≥ 75 nmol/L], insufficient [25(OH)D serum level is 50–75 nmol/L], and deficient [25(OH)D serum level ≤ 50 nmol/L]. The primary outcome was to assess the vitamin D serum level of ischemic stroke patients’ clinical severity at admission and functional independence at discharge. The National Institute of Health Stroke Scale (NIHSS) was used to assess the clinical severity, whereas the modified Rankin scale (mRS) was used to assess functional independence and disability.ResultsThe study included 294 stroke patients, out of 774, who were selected based on the inclusion and exclusion criteria. The mean age of the participants was 68.2 ± 13.4 years, and 49.3% were male. The patients’ distribution among the three groups based on their vitamin D levels is: normal (n = 35, 11.9%), insufficient (n = 66, 22.5%), and deficient (n = 196, 65.6%). After adjusting for potential covariates, regression analysis found a significant inverse relationship of NIHSS based on 25(OH)D serum level (beta coefficient: −0.04, SE: 0.01, p = 0.003). Patients with deficient serum vitamin D level also had significantly higher odds of worse functional independence in mRS score [OR: 2.41, 95%CI: (1.13–5.16), p = 0.023] when compared to participants with normal vitamin D level.ConclusionLow vitamin D levels were associated with higher severity of stroke at admission and poor functional independence and disability at discharge in patients with acute ischemic stroke. Further randomized clinical and interventional studies are required to confirm our findings

МАЛОИЗВЕСТНЫЕ БАКТЕРИИ, ВЫДЕЛЕННЫЕ ПРИ ЗАБОЛЕВАНИЯХ ЧЕЛОВЕКА

The paper is devoted to the study of little-known and previously unknown bacteria isolated from patients with various diseases. Here we present the data on 22 strains that are little-known or previously unknown as human pathogens and isolated from patients with various diseases. Most of the isolates were found to have multiple antibiotic resistances. Moreover, in many conditions potentially pathogenic spore-forming bacteria were identified. Spore formation provides bacteria for survival in the environment and promotes high resistance to antiseptics and disinfectants. Spore-forming bacteria are high survival and especially dangerous as potential hospital-acquired infections because of its antibiotic resistance but the activity of this antibiotic therapy doesn’t concern microbial spores.Работа посвящена изучению малоизвестных и ранее не известных бактерий, изолированных у больных с патологиями различной локализации. Выделенные и изученные 22 штамма малоизвестных бактерий или вообще не описаны ранее как возбудители заболеваний человека, или обнаружены при патологии другой локализации. Большинство полученных бактерий обладает множественной  устойчивостью к различным  антибиотикам. При  разных  заболеваниях в материале обнаружено много потенциально-патогенных спорообразующих   бактерий. Спорообразование   обеспечивает бактериям  сохранение  жизнеспособности в окружающей среде и повышенную устойчивость к антисептикам и дезинфектантам. Спорообразующие бактерии хорошо   сохраняются   и особенно  опасны  в качестве потенциальных  возбудителей внутрибольничных   инфекций,   поскольку резистентны к антибиотикотерапии, активность которой не распространяется на микробные споры

Human brain contains a novel non-AT1, non-AT2 binding site for active angiotensin peptides

AIMS: To determine whether the novel non-AT1, non-AT2 binding site for angiotensins recently discovered in rodent brains occurs in the human brain. MAIN METHODS: Radioligand binding assays of (125)I-sarcosine(1), isoleucine(8) angiotensin II binding were carried out in homogenates of the rostral pole of the temporal cortex of human brains containing 0.3 mM parachloromercuribenzoate (PCMB), 10 microM losartan to saturate AT1 receptors, 10 microM PD123319 to saturate AT2 receptors, with or without 10 microM angiotensin II to define specific binding. Competition binding assays employed a variety of angiotensin peptides, specific angiotensin receptor antagonists, several neuropeptides and an endopeptidase inhibitor to determine pharmacological specificity for this binding site. KEY FINDINGS: The novel non-AT1, non-AT2 binding site was present in similar amounts in female and male brains: Bmax 1.77+/-0.16 and 1.52+/-0.17 fmol/mg initial wet weight in female and male brains, respectively. The K(D) values, 1.79+/-0.09 nM for females, and 1.53+/-0.06 nM for males were also similar. The binding site shows pharmacological specificity similar to that in rodent brains: sarcosine(1), isoleucine(8) angiotensin II\u3eangiotensin III\u3eangiotensin II\u3eangiotensin I\u27angiotensin IV\u3eangiotensin 1-7. Shorter angiotensin fragments and non-angiotensin peptides showed low affinity for this binding site. SIGNIFICANCE: The presence in human brain of this novel non-AT1, non-AT2 binding site supports the concept that this binding site is an important component of the brain angiotensin system. The functional significance of this binding site, either as a novel angiotensin receptor or a highly specific angiotensinase remains to be determined