Resonant Scattering of Emission Lines in Coronal Loops: Effects on Image Morphology and Line Ratios

We have investigated the effects of resonant scattering of emission lines on the image morphology and intensity from coronal loop structures. It has previously been shown that line of sight effects in optically thin line emission can yield loop images that appear uniformly bright at one viewing angle, but show ``looptop sources'' at other viewing angles. For optically thick loops where multiple resonant scattering is important, we use a 3D Monte Carlo radiation transfer code. Our simulations show that the intensity variation across the image is more uniform than the optically thin simulation and, depending on viewing angle, the intensity may be lower or higher than that predicted from optically thin simulations due to scattering out of or into the line of sight.Comment: Accepted for publication in Ap

Summary care record early adopter programme: an independent evaluation by University College London.

Benefits The main potential benefit of the SCR is considered to be in emergency and unscheduled care settings, especially for people who are unconscious, confused, unsure of their medical details, or unable to communicate effectively in English. Other benefits may include improved efficiency of care and avoidance of hospital admission, but it is too early for potential benefits to be verified or quantified. Progress As of end April 2008, the SCR of 153,188 patients in the first two Early Adopter sites (Bolton and Bury) had been created. A total of 614,052 patients in four Early Adopter sites had been sent a letter informing them of the programme and their choices for opting out of having a SCR. Staff attitudes and usage The evaluation found that many NHS staff in Early Adopter sites (which had been selected partly for their keenness to innovate in ICT) were enthusiastic about the SCR and keen to see it up and running, but a significant minority of GPs had chosen not to participate in the programme and others had deferred participation until data quality improvement work was completed. Whilst 80 per cent of patients interviewed were either positive about the idea of having a SCR or ?did not mind?, others were strongly opposed ?on principle?. Staff who had attempted to use the SCR when caring for patients felt that the current version was technically immature (describing it as ?clunky? and ?complicated?), and were looking forward to a more definitive version of the technology. A comparable technology (the Emergency Care Summary) introduced in Scotland two years ago is now working well, and over a million records have been accessed in emergency and out-of-hours care. Patient attitudes and awareness Having a SCR is optional (people may opt out if they wish, though fewer than one per cent of people in Early Adopter sites have done so) and technical security is said to be high via a system of password protection and strict access controls. Nevertheless, the evaluation showed that recent stories about data loss by government and NHS organisations had raised concerns amongst both staff and patients that human fallibility could potentially jeopardise the operational security of the system. Despite an extensive information programme to inform the public in Early Adopter sites about the SCR, many patients interviewed by the UCL team were not aware of the programme at all. This raises important questions about the ethics of an ?implied consent? model for creating the SCR. The evaluation recommended that the developers of the SCR should consider a model in which the patient is asked for ?consent to view? whenever a member of staff wishes to access their record. Not a single patient interviewed in the evaluation was confident that the SCR would be 100 per cent secure, but they were philosophical about the risks of security breaches. Typically, people said that the potential benefit of a doctor having access to key medical details in an emergency outweighed the small but real risk of data loss due to human or technical error. Even patients whose medical record contained potentially sensitive data such as mental health problems, HIV or drug use were often (though not always) keen to have a SCR and generally trusted NHS staff to treat sensitive data appropriately. However, they and many other NHS patients wanted to be able to control which staff members were allowed to access their record at the point of care. Some doctors, nurses and receptionists, it seems, are trusted to view a person?s SCR, whereas others are not, and this is a decision which patients would like to make in real time

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior

The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a) and transient receptor potential vanilloid 5/6 (TRPV5/V6), as well as 5-hydroxytryptamine receptor 1B (5-HT1B), a G-protein-coupled receptor. To evaluate the role of p11 in peripheral pain pathways, we generated a loxP-flanked (floxed) p11 mouse and used the Cre-loxP recombinase system to delete p11 exclusively from nociceptive primary sensory neurons in mice. p11-null neurons showed deficits in the expression of NaV1.8, but not of annexin 2. Damage-sensing primary neurons from these animals show a reduced tetrodotoxin-resistant sodium current density, consistent with a loss of membrane-associated NaV1.8. Noxious coding in wide-dynamic-range neurons in the dorsal horn was markedly compromised. Acute pain behavior was attenuated in certain models, but no deficits in inflammatory pain were observed. A significant deficit in neuropathic pain behavior was also apparent in the conditional-null mice. These results confirm an important role for p11 in nociceptor function

Exoplanet Transit Variability: Bow Shocks and Winds Around HD 189733b

By analogy with the solar system, it is believed that stellar winds will form bow shocks around exoplanets. For hot Jupiters the bow shock will not form directly between the planet and the star, causing an asymmetric distribution of mass around the exoplanet and hence an asymmetric transit. As the planet orbits thorough varying wind conditions, the strength and geometry of its bow shock will change, thus producing transits of varying shape. We model this process using magnetic maps of HD 189733 taken one year apart, coupled with a 3D stellar wind model, to determine the local stellar wind conditions throughout the orbital path of the planet. We predict the time-varying geometry and density of the bow shock that forms around the magnetosphere of the planet and simulate transit light curves. Depending on the nature of the stellar magnetic field, and hence its wind, we find that both the transit duration and ingress time can vary when compared to optical light curves. We conclude that consecutive near-UV transit light curves may vary significantly and can therefore provide an insight into the structure and evolution of the stellar wind.Comment: 9 Pages, 7 figures. Accepted for publication in Monthly Notices of The Royal Astronomical Societ

Tracing the development of dust around evolved stars: The case of 47 Tuc

We observed mid-infrared (7.5-22 mum) spectra of AGB stars in the globular cluster 47 Tuc with the Spitzer telescope and find significant dust features of various types. Comparison of the characteristics of the dust spectra with the location of the stars in a logP-K-diagram shows that dust mineralogy and position on the AGB are related. A 13 mum feature is seen in spectra of low luminosity AGB stars. More luminous AGB stars show a broad feature at 11.5 mum. The spectra of the most luminous stars are dominated by the amorphous silicate bending vibration centered at 9.7 mum. For 47 Tuc AGB stars, we conclude that early on the AGB dust consisting primarily of Mg-, Al- and Fe oxides is formed. With further AGB evolution amorphous silicates become the dominant species.Comment: 2 figures, accepted for publication in ApJ Letter

The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain

Fabry disease is an X-linked lysosomal storage disorder characterised by accumulation of glycosphingolipids, and accompanied by clinical manifestations, such as cardiac disorders, renal failure, pain and peripheral neuropathy. Globotriaosylsphingosine (lyso-Gb3), a deacylated form of globotriaosylceramide (Gb3), has emerged as a marker of Fabry disease. We investigated the link between Gb3, lyso-Gb3 and pain. Plantar administration of lyso-Gb3 or Gb3 caused mechanical allodynia in healthy mice. In vitro application of 100nM lyso-Gb3 caused uptake of extracellular calcium in 10% of sensory neurons expressing nociceptor markers, rising to 40% of neurons at 1μM, a concentration that may occur in Fabry disease patients. Peak current densities of voltage-dependent Ca(2+) channels were substantially enhanced by application of 1μM lyso-Gb3. These studies suggest a direct role for lyso-Gb3 in the sensitisation of peripheral nociceptive neurons that may provide an opportunity for therapeutic intervention in the treatment of Fabry disease-associated pain

Second large-scale Monte Carlo study for the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) represents the next generation of ground based instruments for Very High Energy gamma-ray astronomy. It is expected to improve on the sensitivity of current instruments by an order of magnitude and provide energy coverage from 20 GeV to more than 200 TeV. In order to achieve these ambitious goals Monte Carlo (MC) simulations play a crucial role, guiding the design of CTA. Here, results of the second large-scale MC production are reported, providing a realistic estimation of feasible array candidates for both Northern and Sourthern Hemisphere sites performance, placing CTA capabilities into the context of the current generation of High Energy $\gamma$-ray detectors.Comment: In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589

Monte Carlo Performance Studies of Candidate Sites for the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) is the next-generation gamma-ray observatory with sensitivity in the energy range from 20 GeV to beyond 300 TeV. CTA is proposed to consist of two arrays of 40-100 imaging atmospheric Cherenkov telescopes, with one site located in each of the Northern and Southern Hemispheres. The evaluation process for the candidate sites for CTA is supported by detailed Monte Carlo simulations, which take different attributes like site altitude and geomagnetic field configuration into account. In this contribution we present the comparison of the sensitivity and performance of the different CTA site candidates for the measurement of very-high energy gamma rays.Comment: In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589

A survey of the interaction between security protocols and transport services

This document provides a survey of commonly used or notable network security protocols, with a focus on how they interact and integrate with applications and transport protocols. Its goal is to supplement efforts to define and catalog Transport Services by describing the interfaces required to add security protocols. This survey is not limited to protocols developed within the scope or context of the IETF, and those included represent a superset of features a Transport Services system may need to support