Cell fate reprogramming by control of intracellular network dynamics

Identifying control strategies for biological networks is paramount for practical applications that involve reprogramming a cell's fate, such as disease therapeutics and stem cell reprogramming. Here we develop a novel network control framework that integrates the structural and functional information available for intracellular networks to predict control targets. Formulated in a logical dynamic scheme, our approach drives any initial state to the target state with 100% effectiveness and needs to be applied only transiently for the network to reach and stay in the desired state. We illustrate our method's potential to find intervention targets for cancer treatment and cell differentiation by applying it to a leukemia signaling network and to the network controlling the differentiation of helper T cells. We find that the predicted control targets are effective in a broad dynamic framework. Moreover, several of the predicted interventions are supported by experiments.Comment: 61 pages (main text, 15 pages; supporting information, 46 pages) and 12 figures (main text, 6 figures; supporting information, 6 figures). In revie

Heavy meson semileptonic decays in two dimensions in the large Nc

We study QCD in 1+1 dimensions in the large Nc limit using light-front Hamiltonian perturbation theory in the 1/Nc expansion. We use this formalism to exactly compute hadronic transition matrix elements for arbitrary currents at leading order in 1/Nc, which we use to write the semileptonic differential decay rate of a heavy meson and its moments. We then compare with the results obtained using an effective field theory approach based on perturbative factorization, with the intention of better understanding quark-hadron duality. A very good numerical agreement is obtained between the exact result and the result using effective theories.Comment: Talk given at the High-Energy Physics International Conference on Quantum Chromodynamics, 3-7 July (2006), Montpellier (France